The DOI matches its Crossref record; 216 of the 216 references it cites were found in a registry or an index.
T Cell Dysfunction in Cancer Immunity and Immunotherapy
Open accessAbstract
In cancer, T cells become dysfunctional owing to persistent antigen exposure. Dysfunctional T cells are characterized by reduced proliferative capacity, decreased effector function, and overexpression of multiple inhibitory receptors. Due to the presence of various inhibitory signals in the complex tumor microenvironment, tumor-specific T cells have distinct dysfunction states. Therapeutic reactivation of tumor-specific T cells has yielded good results in cancer patients. Here, we review the hallmarks of T cell dysfunction in cancer. Also, we discuss the relationship between T cell dysfunction and cancer immunotherapy.
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2 retracted
TIGIT predominantly regulates the immune response via regulatory T cells
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Cited by
Stem cell programs in cancer initiation, progression, and therapy resistance
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T Cell Dysfunction and Exhaustion in Cancer
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“Meanwhile, the TME contains a variety of cell types and cytokines (Table 1) that take part in tumor progression, which could contribute to T cell dysfunction (Xia et al., 2019).”
BackgroundSelf-citationBeyond Just Peptide Antigens: The Complex World of Peptide-Based Cancer Vaccines
Stephens, A. J., Burgess-Brown, N. A., & Jiang, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.696791 · Cited by 153
Automated manufacture of autologous CD19 CAR-T cells for treatment of non-hodgkin lymphoma
Jackson, Z., Roe, A., Sharma, A. A., Lopes, F. B. T. P., Talla, A., Kleinsorge-Block, S., Zamborsky, K., Schiavone, J., Manjappa, S., Schauner, R., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01941 · Cited by 102
Exosomal PD‐L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies
Zhou, K., Guo, S., Li, F., Sun, Q., & Liang, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.569219 · Cited by 99
Metadata
- Authors
- Xia, A., Zhang, Y., Xu, J., Yin, T., & Lu, X.-J.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-07-19
- Volume
- 10
- Pages
- 1719-1719
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2961584252
- Cited by
- 341
- References
- 216
- FWCI
- 15.87
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
