Tryptophan Dietary Impacts Gut Barrier and Metabolic Diseases

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677

Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22

Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614

Ido expression by dendritic cells: tolerance and tryptophan catabolism

Mellor, A. L., & Munn, D. H. (2004) · Nature Reviews Immunology · doi:10.1038/nri1457 · Cited by 2,341

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893

Gut microbiota in cardiovascular health and disease

Tang, W. H. W., Kitai, T., & Hazen, S. L. (2017) · Circulation Research · doi:10.1161/circresaha.117.309715 · Cited by 1,670

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Lamas, B., Richard, M. L., Leducq, V., Pham, H.-P., Michel, M.-L., Da Costa, G., Bridonneau, C., Jegou, S., Hoffmann, T. W., Natividad, J. M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4102 · Cited by 1,482

Signals from the gut microbiota to distant organs in physiology and disease

Schroeder, B. O., & Bäckhed, F. (2016) · Nature Medicine · doi:10.1038/nm.4185 · Cited by 1,409

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

Gao, J., Xu, K., Liu, H., Liu, G., Bai, M., Peng, C., Li, T., & Yin, Y. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00013 · Cited by 1,357

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., et al. (2012) · Nature · doi:10.1038/nature11228 · Cited by 1,271

Cannabinoid control of gingival immune activation in chronically SIV-infected rhesus macaques involves modulation of the indoleamine-2,3-dioxygenase-1 pathway and salivary microbiome

McDew‐White, M., Lee, E.-H., Alvarez, X. A., Sestak, K., Ling, B., Byrareddy, S. N., Okeoma, C. M., & Mohan, M. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103769 · Cited by 21

Potential roles of gut microbial tryptophan metabolites in the complex pathogenesis of acne vulgaris

Huang, Y., Liu, L., Hao, Z., Chen, L., Yang, Q., Xiong, X., & Deng, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.942027 · Cited by 24

Neuroprotection of Food Bioactives in Neurodegenerative Diseases: Role of the Gut Microbiota and Innate Immune Receptors

Sun, Y., Ho, C., & Zhang, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c07742 · Cited by 21

Gut microbiota-derived metabolites and chronic inflammatory diseases

Vargas, A., Robinson, B. L., Houston, K., Sangay, A. R. V., Saadeh, M., D’Souza, S. M., & Johnson, D. A. (2025) · Exploration of Medicine · doi:10.37349/emed.2025.1001275 · Cited by 24

Mechanisms and Therapeutic Potential of Key Anti-inflammatory Metabiotics: Trans-Vaccenic Acid, Indole-3-Lactic Acid, Thiamine, and Butyric Acid

Muñoz-Olivos, C., Bautista, E., Jose, R.-A. M., Berenice, P.-G., Zacapa, D., & Cortez-Sánchez, J. L. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10475-9 · Cited by 26

Gut microbiota – indole-3-acetic acid axis in cancer: dual functions, mechanistic insights, and therapeutic potential

Zhong, L., Boopathi, S., Purushothaman, B., Tu, Q., & Zhang, Y. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128293 · Cited by 23

Liquid chromatography-mass spectrometry untargeted metabolomics reveals increased levels of tryptophan indole metabolites in urine of metabolic syndrome patients

Guerrero-Esperanza, M., Wróbel, K., Ojeda, A. G., Garay‐Sevilla, M. E., Escobosa, A. R. C., Barrientos, E. Y., & Wróbel, K. (2020) · European Journal of Mass Spectrometry · doi:10.1177/1469066720964632 · Cited by 21

Intestinal Microbial Metabolites in Ankylosing Spondylitis

Scalise, G., Ciancio, A., Mauro, D., & Ciccia, F. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153354 · Cited by 25

Role of Gut Microbiota in Cannabinoid-Mediated Suppression of Inflammation

Varsha, K. K., Nagarkatti, M., & Nagarkatti, P. S. (2022) · Advances in Drug and Alcohol Research · doi:10.3389/adar.2022.10550 · Cited by 24

Exploring the roles of intestinal flora in enhanced recovery after surgery

Liu, Z., Li, N., Dang, Q., Liu, L., Wang, L., Li, H., & Han, X. (2023) · iScience · doi:10.1016/j.isci.2023.105959 · Cited by 24

From Microbes to Metabolites: Advances in Gut Microbiome Research in Type 1 Diabetes

Blok, L. C. H. M., Hanssen, N. M. J., Nieuwdorp, M., & Rampanelli, E. (2025) · Metabolites · doi:10.3390/metabo15020138 · Cited by 21

Tryptophan, an important link in regulating the complex network of skin immunology response in atopic dermatitis

Huang, Y., Chen, L., Liu, F., Xiong, X., Ouyang, Y., & Deng, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1300378 · Cited by 21

Intestinal Stem Cells Damaged by Deoxycholic Acid via AHR Pathway Contributes to Mucosal Barrier Dysfunction in High-Fat Feeding Mice

Liu, L., Xu, J., Xu, X., Mao, T., Niu, W., Wu, X., Lu, L., & Zhou, H. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415578 · Cited by 19

The Gut Microbiome and Its Multifaceted Role in Cancer Metabolism, Initiation, and Progression: Insights and Therapeutic Implications

Xu, K., Motiwala, Z. Y., Corona‐Avila, I., Makhanasa, D., Alkahalifeh, L., & Khan, M. W. (2025) · Technology in Cancer Research & Treatment · doi:10.1177/15330338251331960 · Cited by 22

Review: microbial metabolites – a key to address gut inflammation and barrier dysfunction in the premature infant

Robertson, K. M., Cermack, K., Woodruff, T., Carter, S. R., Jala, V. R., & Buonpane, C. L. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2551117 · Cited by 18

Tryptophan metabolism at the crossroads of the neuro-immuno-microbial axis: implications for precision medicine in chronic diseases

Xia, H.-H., & Huang, J. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1707850 · Cited by 18

Postbiotics Implication in the Microbiota-Host Intestinal Epithelial Cells Mutualism

Kaur, H., Kaur, G., & Ali, S. A. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10062-w · Cited by 18

The effects of whole grain cereals on tryptophan metabolism and intestinal barrier function: underlying factors of health impact

Liikonen, V., Gómez-Gallego, C., & Kolehmainen, M. (2023) · Proceedings of The Nutrition Society · doi:10.1017/s0029665123003671 · Cited by 15

Candida albicans in celiac disease: A wolf in sheep’s clothing

Lerner, A., & Matthias, T. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102621 · Cited by 17

Breastfeeding importance and its therapeutic potential against SARS‐CoV‐2

da Costa, A. V., Goes, C. P., & Gama, P. (2021) · Physiological Reports · doi:10.14814/phy2.14744 · Cited by 17

Targeting gut microbiota in non-alcoholic fatty liver disease (NAFLD): Pathogenesis and therapeutic insights: A review

Bian, S., Zhu, S., Lu, J., Iqbal, M., Jamil, T., Kiani, F. A., Dong, H., Dai, H., Zhang, X., Liu, F., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147995 · Cited by 15

Metabolic Profiling Reveals Altered Tryptophan Metabolism in Patients with Kawasaki Disease

Fan, X., Li, K., Guo, X., Liao, S., Zhang, Q., Xu, Y., Cui, H., Zheng, L., & Xu, M. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1180537 · Cited by 15

Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria

Ji, G., Zhao, J., Si, X., & Song, W. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115345 · Cited by 16

Correlations Between Gut Microbiota Composition, Medical Nutrition Therapy, and Insulin Resistance in Pregnancy—A Narrative Review

Enache, R. M., Roşu, O. A., Profir, M., Pavelescu, L. A., Creţoiu, S. M., & Gașpar, B. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031372 · Cited by 14

Unraveling the complexities of diet induced obesity and glucolipid dysfunction in metabolic syndrome

Dutta, B., Tripathy, A., Archana, P. R., & Kamath, S. U. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01837-y · Cited by 19

Metabolomics and metagenomics in mice reveal the role of the gut microbiota in tryptophan metabolism

Levé, M., Manghi, P., Bredon, M., Lefèvre, A., Manara, S., Armanini, F., Emond, P., Planchais, J., Rolhion, N., Segata, N., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113751 · Cited by 16

Exploring nicotinamide adenine dinucleotide precursors across biosynthesis pathways: Unraveling their role in the ovary

Ren, C., Shuang, Z., Chen, Y., Deng, K., Kuang, M., Gong, Z., Zhang, K., Wang, P., Huang, P., Zhou, Z., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202400453r · Cited by 14

Is there a role for microbiome-based approach in common variable immunodeficiency?

Poto, R., Ianiro, G., de Paulis, A., Spadaro, G., Marone, G., Gasbarrini, A., & Varricchi, G. (2023) · Clinical and Experimental Medicine · doi:10.1007/s10238-023-01006-3 · Cited by 16

Maturation of the Visceral (Gut-Adipose-Liver) Network in Response to the Weaning Reaction versus Adult Age and Impact of Maternal High-Fat Diet

Guzzardi, M. A., Rosa, F. L., Campani, D., Insilla, A. C., Sena, V. D., Panetta, D., Brunetto, M. R., Bonino, F., Collado, M. C., & Iozzo, P. (2021) · Nutrients · doi:10.3390/nu13103438 · Cited by 13

Baitouweng decoction alleviates ulcerative colitis by regulating tryptophan metabolism through DOPA decarboxylase promotion

Zhang, J., Lin, B., Zhang, Y., Hu, X., Liu, T., Liu, E., & Liu, S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1423307 · Cited by 16

The Other Obesity Epidemic—Of Drugs and Bugs

Sfera, A., Osorio, C. P., Diaz, E. L., Maguire, G., & Cummings, M. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00488 · Cited by 13

An Investigation into the Temporal Reproducibility of Tryptophan Metabolite Networks Among Healthy Adolescents

Oluwagbemigun, K., Anesi, A., Clarke, G. A., Schmid, M. C., Mattivi, F., & Nöthlings, U. (2021) · International Journal of Tryptophan Research · doi:10.1177/11786469211041376 · Cited by 12

Biomarkers of geroprotection and cardiovascular health: An overview of omics studies and established clinical biomarkers in the context of diet

Secci, R., Hartmann, A., Walter, M., Grabe, H. J., der Auwera, S. V., Kowald, A., Palmer, D. H., Rimbach, G. H., Fuellen, G., & Barrantes, I. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1975638 · Cited by 11

Effect of Different Dietary Regimes on the Gut Microbiota and Fecal Metabolites of Père David’s Deer

Zhen, J., Ren, Y., Zhang, H., Yuan, X., Wang, L., Shen, H., Liu, P., & Chen, Y. (2022) · Animals · doi:10.3390/ani12050584 · Cited by 12

Interactive relationship between Trp metabolites and gut microbiota: The impact on human pathology of disease

Khoshnevisan, K., Chehrehgosha, M., Conant, M., Meftah, A. M., Baharifar, H., Ejtahed, H., Angoorani, P., Gholami, M., Sharifi, F., Maleki, H., et al. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15533 · Cited by 12

Tryptophan–kynurenine metabolites associate with inflammation and immunologic phenotypes in common variable immunodeficiency

Jørgensen, S. F., Braadland, P. R., Ueland, T., Fraz, M. S. A., Michelsen, A. E., Holm, K., Osnes, L., Trøseid, M., Ueland, P. M., Fevang, B., et al. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.04.031 · Cited by 11

Therapeutic potential of tryptophan metabolite indoleacrylic acid in inflammatory bowel disease: From cellular mechanisms to zebrafish stress-like behavior

Amarasiri, R. P. G. S. K., Hyun, J., Lee, S.-W., Kim, J.-I., Lee, H., Ryu, B., & Jeon, Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114207 · Cited by 10

Indole dysbiosis and mucosal inflammation

Kim, J. Y., Cartwright, I. M., & Colgan, S. P. (2025) · Microbiota and Host · doi:10.1530/mah-25-0004 · Cited by 9

The gut microbiota-derived metabolites regulate bone extracellular matrix homeostasis: Mechanisms and therapeutic implications

Li, Y., Liu, K., Li, Y., Tang, Z., Li, Y., Li, J., & Zhang, H. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112245 · Cited by 10

Analysis of tryptophan metabolites and related compounds in human and murine tissue: development and validation of a quantitative and semi-quantitative method using high resolution mass spectrometry

Abujrais, S., Ubhayasekera, S. J. K. A., & Bergquist, J. (2024) · Analytical Methods · doi:10.1039/d3ay01959d · Cited by 8

Nanovesicular Mediation of the Gut–Brain Axis by Probiotics: Insights into Irritable Bowel Syndrome

Santonocito, R., Paladino, L., Vitale, A. M., D’Amico, G., Zummo, F. P., Pirrotta, P., Raccosta, S., Manno, M., Accomando, S., D’Arpa, F., et al. (2024) · Biology · doi:10.3390/biology13050296 · Cited by 10

Decoding the bidirectional relationship between gut microbiota and COVID-19

Ralli, T., Saifi, Z., Rathee, A. S., Aeri, V., & Kohli, K. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13801 · Cited by 10

Microbiome-metabolomics analysis reveals abatement effects of itaconic acid on odorous compound production in Arbor Acre broilers

Zhu, X., Zhang, Y., Liu, H., Yang, G., & Li, L. (2023) · BMC Microbiology · doi:10.1186/s12866-023-02914-w · Cited by 9

Harnessing Dietary Tryptophan: Bridging the Gap Between Neurobiology and Psychiatry in Depression Management

Chehadi, A. C., Pereira de Lima, E., Detregiachi, C. R. P., Santos de Argollo Haber, R., Catharin, V. M. C. S., Fornari Laurindo, L., Engracia Valenti, V., Machado Galhardi, C., Tanaka, M., & Maria Barbalho, S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27010465 · Cited by 8

The gut microbiome as a modulator of arterial function and age-related arterial dysfunction

Longtine, A. G., Greenberg, N., de Quirós, Y. B., & Brunt, V. E. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00764.2023 · Cited by 9

Increased Tryptophan Catabolism Provides Predictive Value to Chronic Heart Failure Patients with Low-Grade Inflammation

Wang, H., Wu, J., Wei, H., Zhang, Y., Wang, Y., & Wang, D. W. (2024) · Inflammation · doi:10.1007/s10753-024-02100-8 · Cited by 8

Comparative analysis of Seabuckthorn and its significant component in enhancing fish mucosal immunity

Liu, Y., Su, L. F., Cao, D., Wu, N., Hu, Y., Altaf, F., Li, J., Zhu, Q., Liu, J., Zhang, Q., et al. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741752 · Cited by 8

Metabolomics of follicular fluid reveals the impact of heat stress on oocyte pick-up and in vitro embryo production efficiency in dairy cows

Li, Y., Wei, Y., Yang, M., Sun, M., Yan, L., Yang, Y., Zhang, Y., Wang, Y., Lin, P., & Jin, Y. (2025) · Journal of Animal Science · doi:10.1093/jas/skaf216 · Cited by 8

Dietary Modulation of the Enteric Nervous System: From Molecular Mechanisms to Therapeutic Applications

Wang, X. J., Zhang, W., Wang, H. H., Zhao, Y., Wang, P., Wang, R., Sun, Y., Ren, F., & Li, Y. (2025) · Nutrients · doi:10.3390/nu17223519 · Cited by 8

Tryptophan Metabolism in Neurodevelopment and Its Implications For Neurodevelopmental Disorders

Giuliano, M. G., & Tognini, P. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05437-9 · Cited by 10

Analysis of the Alterations in Symbiotic Microbiota and Their Correlation with Intestinal Metabolites in Rainbow Trout (Oncorhynchus mykiss) Under Heat Stress Conditions

Zhou, C. Q., & Ding, F. (2025) · Animals · doi:10.3390/ani15142017 · Cited by 7

Cell Signaling by Tryptophan Catabolism

Torrelli-Diljohn, A., Kulkarni, B., & Vitturi, D. A. (2026) · Biochemistry · doi:10.1021/acs.biochem.6c00179 · Cited by 7

New mechanistic insights of anti-obesity by sleeve gastrectomy-altered gut microbiota and lipid metabolism

Liu, C., Xu, Q., Dong, S., Ding, H., Li, B., Zhang, D., Liang, Y., Li, L., Liu, Q., Cheng, Y., et al. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1338147 · Cited by 7

Deciphering the microbial map and its implications in the therapeutics of neurodegenerative disorder

Vashishth, S., Ambasta, R. K., & Kumar, P. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102466 · Cited by 8

Role of the Intestinal Microbiota in the Genesis of Major Depression and the Response to Antidepressant Drug Therapy: A Narrative Review

Mundula, T., Baldi, S., Gerace, E., & Amedei, A. (2023) · Biomedicines · doi:10.3390/biomedicines11020550 · Cited by 10

Alteration of Community Metabolism by Prebiotics and Medicinal Herbs

Peterson, C. T., Pérez‐Santiago, J., Iablokov, S. N., Rodionov, D. A., & Peterson, S. N. (2023) · Microorganisms · doi:10.3390/microorganisms11040868 · Cited by 7

Novel plant-derived compounds modulate gut microbiome dysbiosis in colitis mice: A potential therapeutic avenue for inflammatory bowel disease

Rahaman, M. M., Yeshi, K., Bappi, M. H., Islam, Z., Wangchuk, P., & Sarker, S. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128343 · Cited by 6

Reprogramming offspring liver health: maternal indole supplementation as a preventive strategy against MASLD

Mandala, A., Undi, R. B., Janssen, R. C., Sugino, K. Y., Zhao, W., Nelson, B. N., Teague, A. M., Patil, N. Y., Berry, K. A. Z., Varshney, R., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.106098 · Cited by 7

Quality control for a traditional Chinese medicine, Millettia speciosa Champ, using ultra-high-performance liquid chromatography fingerprint, serum pharmacochemistry and network pharmacology

Nong, Y., Zhang, C., Guo, Y., Qin, Y., Zhong, X., Feng, L., Pan, Z., Deng, L., Guo, H., & Su, Z. (2023) · Analytical Methods · doi:10.1039/d3ay01051a · Cited by 6

Microbiota and beneficial metabolites in colorectal cancer

González, A., Fullaondo, A., Odriozola, I., & Odriozola, A. (2024) · Advances in genetics · doi:10.1016/bs.adgen.2024.08.002 · Cited by 6

Tryptophan was metabolized into beneficial metabolites against coronary heart disease or prevented from producing harmful metabolites by the in vitro drug screening model based on Clostridium sporogenes

Tian, X., Wu, Y., Duan, C., Zhou, X., Li, Y., Zheng, J., Lai, W., Zhang, S., Cao, L., & Zhong, S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1013973 · Cited by 7

Indole metabolism and its role in diabetic macrovascular and microvascular complications

Hu, W., Garrison, C., Prasad, R., Boulton, M., & Grant, M. B. (2025) · American Heart Journal Plus Cardiology Research and Practice · doi:10.1016/j.ahjo.2025.100532 · Cited by 4

Targeting the gut-retina axis: mechanistic insights and therapeutic prospects for diabetic retinopathy

Jiang, Y. Z., Tang, Y., Liu, Z., Yang, X., Zhou, M.-Y., Liang, Y., Ding, J., & Liao, Y. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-02022-3 · Cited by 5

Egg-derived bioactive peptides IQW and IRW alleviate Escherichia coli diarrhea based on the CaSR-mediated NF-κB/MAPK pathway

Ding, S., Chen, Y., Chai, Y., Liu, G., Liu, N., & Fang, J. Q. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.105949 · Cited by 5

Antibiotic‐Induced Dysbiosis of the Gut Microbiota Shifts Host Tryptophan Metabolism and Increases the Susceptibility of Mice to Pulmonary Infection With Pseudomonas aeruginosa

de Brito, C. B., Arifa, R. D. D. N., Bezerra, R. D. O., Igídio, C. E. D., de Amorim‐Santos, B. M., Santos, A. C. P. D. M., Barbosa, L. M., Barbosa, J. P. P., Cassiano, L. M. G., Kohlhoff, M., et al. (2025) · Immunology · doi:10.1111/imm.13932 · Cited by 5

The intestine and cardiovascular disease

Delk, S. C., Reddy, S. T., & Fogelman, A. M. (2025) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000001001 · Cited by 4

Gut-microbiota-derived 3-indoleacrylic acid alleviates neonatal necrotizing enterocolitis by inhibiting epithelial necroptosis

Dong, X., Wang, M., Wang, B., Li, H., Cao, Z., Li, B., Zou, X., Kong, X., Yang, H., Zhou, Y., et al. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.102721 · Cited by 4

Integrative serum and fecal metabolomics reveal the role of gut microbe-associated metabolites of curcumin nanoparticles in ulcerative colitis intervention

Yang, J., Lin, J., Wang, Y., Li, C., & Xie, J. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107300 · Cited by 5

Investigating the role of IDO1 in tumors: correlating IDO1 expression with clinical pathological features and prognosis in lung adenocarcinoma patients

Yin, Z., Sun, B., Wang, S., Xi Tao, X. U., Cheng, L., Gao, Y., & Jin, E. (2025) · PeerJ · doi:10.7717/peerj.18776 · Cited by 4

Effects of 3-indoleacrylic acid on alleviating lipopolysaccharide-induced liver inflammatory damage in laying hens

Zhang, Q., Wang, Y., Wang, Y., Yuan, J., Wang, Y., Zeng, Y., Zhang, H., Yang, H., Ma, Q., Shi, D., et al. (2025) · Poultry Science · doi:10.1016/j.psj.2025.105307 · Cited by 5

RNA-seq reveals insights into molecular mechanisms of metabolic restoration via tryptophan supplementation in low birth weight piglet model

Xiao, P., Goodarzi, P., Pezeshki, A., & Hagen, D. E. (2022) · Journal of Animal Science · doi:10.1093/jas/skac156 · Cited by 4

The early faecal microbiota transfer alters bile acid circulation and amino acid transport of the small intestine in piglets

Teng, T., Sun, G., Song, X., & Shi, B. (2022) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13739 · Cited by 4

Aromatic Amino Acids and Their Interactions with Gut Microbiota-Related Metabolites for Risk of Gestational Diabetes: A Prospective Nested Case-Control Study in a Chinese Cohort

Li, N., Li, J., Wang, H., Liu, J., Li, W., Yang, K., Huo, X., Leng, J., Yu, Z., Hu, G., et al. (2023) · Annals of Nutrition and Metabolism · doi:10.1159/000531481 · Cited by 5

Tackling Immune Pathogenesis of COVID-19 through Molecular Pharmaceutics

Puccetti, M., Costantini, C., Ricci, M., & Giovagnoli, S. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13040494 · Cited by 4

Microbial tryptophan catabolism affects the vector competence of AnophelesPreprint

Feng, Y., Peng, Y., Wen, H., Song, X., An, Y., Tang, H., & Wang, J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.15.431262 · Cited by 4

Identification of tryptophan metabolism-related biomarkers for nonalcoholic fatty liver disease through network analysis

Jiang, C., Liang, J., Hu, K., Ye, Y., Yang, J., Zhang, X., Ye, G., Zhang, J., Zhang, D., Zhong, B., et al. (2025) · Endocrine Connections · doi:10.1530/ec-24-0470 · Cited by 3

The mediating role of caffeine and biological age in the association between dietary index for gut microbiota and osteoporosis

Li, Y., Cao, H., & Zhang, J. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1559674 · Cited by 3

Unlocking healthy aging through gut microbial tryptophan metabolism

Xu, L., Valencak, T. G., Wang, L., Wang, X., Li, X., & Sun, H. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108229 · Cited by 3

Dysregulated tryptophan metabolism contributes to metabolic syndrome in Chinese community-dwelling older adults

Sun, S., Hu, F., Sang, Y., Wang, S., Liu, X., Shi, J., Cao, H., Tao, F., & Liu, K. (2025) · BMC Endocrine Disorders · doi:10.1186/s12902-024-01826-8 · Cited by 3

The Interplay of Diet, Genome, Metabolome, and Gut Microbiome in Cardiovascular Disease: A Narrative Review

Mofrad, M. D., Ahn, S., & Chun, O. K. (2025) · Current Medicinal Chemistry · doi:10.2174/0109298673342364241119114722 · Cited by 3

Metabolism of Dietary Substrates by Intestinal Bacteria and Consequences for the Host Intestine

Blachier, F. (2023) · Springer eBooks · doi:10.1007/978-3-031-26322-4_3 · Cited by 4

Caveolae with serotonin and NMDA receptors as promising targets for the treatment of Alzheimer’s disease

Nakashima, M. (2024) · International Journal of Physiology Pathophysiology and Pharmacology · doi:10.62347/mtwv3745 · Cited by 3

MAFLD under the lens: the role of gut microbiota

Sousa, P., & Machado, M. V. (2022) · Metabolism and Target Organ Damage · doi:10.20517/mtod.2022.15 · Cited by 3

Bifunctional Photoelectrochemical Sensors Based on Co3O4/rGO/TiO2/NF Nanostructures for Depression Screening and Diagnosis

Tao, B., Guo, H., Miao, F., & Zhao, M. (2024) · IEEE Sensors Journal · doi:10.1109/jsen.2024.3408455 · Cited by 2

Traditional Chinese Medicine Improves the Development of Vascular Thrombotic Inflammation: The Key Role of Gut Microbiota and Its Derived Metabolites

Xu, J., Zhang, Y., Liao, J., Le, W., Wu, G., & Zhang, W. (2025) · Phytotherapy Research · doi:10.1002/ptr.70012 · Cited by 3

HIV-associated gut dysbiosis drives oncogenesis through metabolic-immune crosstalk: mechanisms and therapeutic implications

Meng, Q., Xu, L., Xu, F., Shen, X., & Yue, J. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1634388 · Cited by 3

Prenatal Poly I:C exposure affects tryptophan-kynurenine metabolism associated with intestinal microbiome in female juvenile rats

Yang, L., Chen, H., Zeng, M., Lu, Y., Chen, X., Cao, Z., Zhong, F., Yang, X., Shen, A., Su, Y., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1669845 · Cited by 2

Dietary influences on the gut-brain pathways: Mechanisms and therapeutic potential

Ajay, A., Gaur, S. S., Singh, J., Shams, R., Dash, K. K., Shaikh, A. M., & Kovács, B. (2025) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2025.200349 · Cited by 2

Gut microbiota mediates the anti-obesity effects of Gnaphalium affine methanol extract in HFD-induced obesity

Yu, Z., Ma, H., Zhang, H., Gao, L., Fu, X., Wang, H., Xiao, Y., Wu, X., Zhang, A., Kang, Y., et al. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1779459 · Cited by 2

Role of the gut microbiome in the pathophysiology of brain disorders

Mayer, E. A., Horn, J. V., Mayer, E. D., & Chen, S. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85654-6.00058-7 · Cited by 2

Are tryptophan metabolites new predictive biomarkers for CVD?

Taleb, S. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117385 · Cited by 2

The interaction between gut microbiota and chronic kidney disease and the prospects of probiotic intervention

Meng, Y., Zhao, M., Lü, H., Yi, H., Zhang, Z., & Zhang, L. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250177 · Cited by 1

The Gut Vascular Barrier: Linking the Intestinal Environment with Blood Circulation

Carloni, S., & Strati, F. (2025) · The microbiomes of humans, animals, plants, and the environment · doi:10.1007/978-3-031-84065-4_4 · Cited by 2

Polycystic Ovary Syndrome PCOS and Depression Role of Neuroinflammation

Ramezanpour, M. R., Bahrami, O., Pashazadeh, M., Sarallah, R., Nikfar, R., & Zolbin, M. M. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-5908-2.ch007 · Cited by 1

Microbiota and fatty liver disease: Potential candidate for therapeutic intervention

Eslami, M., Naderian, R., Tarahomi, M., Babaeizad, A., Amini, P., & Pouya, P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27370-4.00026-3 · Cited by 1

The causal association between plasma amino acid levels and abdominal aortic aneurysm: insights from Mendelian randomization and an experimental validation.

Li, M.-H., Xiao, S.-S., Fu, K.-Y., Qin, Q., Wang, L.-C., Li, X., Shu, C., & Li, J.-H. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178695 · Cited by 1

Biomarkers of oxidative damage as a tool to investigate frailty syndrome in older women

Sepúlveda, M. I., Palomo, I., Lagos, F., Pardo, X., López‐Alarcón, C., Ávila, F., & Eduardo Fuentes, Q. (2026) · npj Aging · doi:10.1038/s41514-026-00372-y · Cited by 1

Galacto-oligosaccharides ameliorate polystyrene nanoplastic-induced anxiety- and depression-like behaviors via a gut-initiated serotonergic cascade

Liu, C., Wu, B., Luo, M., Li, L., & Li, L. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.128276 · Cited by 2

Food processing-derived carbon dots disrupt male fertility via the gut-testis axis

Chen, P., My, M., Li, Y., Chen, X. S., Xu, Z., Guo, J., Hu, X., Lv, L., Guo, J., & Liu, G. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3252-6 · Cited by 1

Metabolic Profiling Reveals Altered Tryptophan Metabolism in Patients with Kawasaki DiseasePreprint

Fan, X., Li, K., Guo, X., Liao, S., Zhang, Q., Xu, Y., Cui, H., Zheng, L., & Xu, M. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4173453 · Cited by 1

Métabolisme du tryptophane et interactions avec le microbiote intestinal

Laurans, L., & Taleb, S. (2021) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2021.01.001 · Cited by 2

Exploring tryptophan metabolism in cardiometabolic diseases

Mouttoulingam, N., & Taleb, S. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.11.009 · Cited by 17

En finir avec la chrononutrition ?

Riché, D. (2009) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2009.02.003

Discrete interplay of gut microbiota L-tryptophan metabolites in host biology and disease

Ranhotra, H. S. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04867-0 · Cited by 28

Tryptophan Metabolism in Digestive and Extra-Digestive Diseases: Mechanisms, Clinical Implications, and Therapeutic Perspectives

Tohumcu, E., Puca, F. S., Tunalı, V., Cerrito, L., Pallozzi, M., Stella, L., Maestri, M., Murace, C. A., Porcari, S., Varca, S., et al. (2026) · Nutrients · doi:10.3390/nu18172849