The DOI matches its Crossref record; 192 of the 192 references it cites were found in a registry or an index.
DAMPs and NETs in Sepsis
Open accessAbstract
Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to infection. Much has been focused on host response to pathogens mediated through the interaction of pathogen-associated molecular patterns (PAMPs) and pattern recognition receptors (PRRs). PRRs are also activated by host nuclear, mitochondrial, and cytosolic proteins, known as damage-associated molecular patterns (DAMPs) that are released from cells during sepsis. Some well described members of the DAMP family are extracellular cold-inducible RNA-binding protein (eCIRP), high mobility group box 1 (HMGB1), histones, and adenosine triphosphate (ATP). DAMPs are released from the cell through inflammasome activation or passively following cell death. Similarly, neutrophil extracellular traps (NETs) are released from neutrophils during inflammation. NETs are webs of extracellular DNA decorated with histones, myeloperoxidase, and elastase. Although NETs contribute to pathogen clearance, excessive NET formation promotes inflammation and tissue damage in sepsis. Here, we review DAMPs and NETs and their crosstalk in sepsis with respect to their sources, activation, release, and function. A clear grasp of DAMPs, NETs and their interaction is crucial for the understanding of the pathophysiology of sepsis and for the development of novel sepsis therapeutics.
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(DeCOI), G. C.-1. O. I., Aschenbrenner, A. C., Mouktaroudi, M., Krämer, B., Oestreich, M., Antonakos, N., Nuesch-Germano, M., Gkizeli, K., Bonaguro, L., Reusch, N., et al. (2021) · Genome Medicine · doi:10.1186/s13073-020-00823-5 · Cited by 255
Quijada, H., Bermudez, T., Kempf, C. L., Valera, D. G., Garcia, A. N., Camp, S. M., Song, J. H., Franco, E., Burt, J. K., Sun, B., et al. (2021) · European Respiratory Journal · doi:10.1183/13993003.02536-2020 · Cited by 88
Caicedo, A., Zambrano, K., Sanon, S., Luis Vélez, J., Montalvo, M., Jara, F., Moscoso, S. A., Vélez, P., Maldonado, A., & Velarde, G. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.02.014 · Cited by 48
Metadata
- Authors
- Denning, N.-L., Aziz, M., Gurien, S. D., & Wang, P.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-10-30
- Volume
- 10
- Pages
- 2536-2536
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2982600436
- Cited by
- 623
- References
- 192
- FWCI
- 17.38
- Type
- journal article
- Language
- en
- Open access
- gold
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- Denning, N.-L., Aziz, M., Gurien, S. D., & Wang, P. (2019). DAMPs and NETs in Sepsis. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2019.02536
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