A Role for Dogs in Advancing Cancer Immunotherapy Research
Open accessAbstract
The field of immuno-oncology has advanced so rapidly that there is large need for additional new animal models with which to effectively and efficiently evaluate cancer immunotherapies, particularly immunotherapy combinations with conventional therapeutics, including targeted agents, chemotherapy, and radiation therapy. While current rodent cancer models are essential for early proof-of-concept and mechanistic studies for immune therapies, these models have limitations with regards to predicting the ultimate effectiveness of new immunotherapies in humans. The value of the dog cancer model was recently recognized by the National Institute of Medicine. Therefore, this review is intended to summarize key aspects of the dog cancer model that make the model particularly well-suited to evaluating new cancer immunotherapies and drug combinations. The review will focus on areas of investigation and cancer types in which the dog model currently is most likely to impact clinical immuno-oncology research and new drug development. Immune reagent availability is discussed, along with some unique challenges associated with the dog immunotherapy model. The intent of this review is to increase awareness of the dog cancer model and stimulate additional studies that may benefit both man and man’s best friend.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The integrated canine approach has been particularly promising for evaluating anti-metastatic and immune-based therapeutics.
“This integrated approach has been particularly promising for the evaluation of anti-metastatic 99,234 and immune-based therapeutics 69,235 .”
From Osteosarcoma (2022) · cites this paper as [235]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Translation of new cancer treatments from pet dogs to humans
Paoloni, M., & Khanna, C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2273 · Cited by 668 · see citing works
Spontaneously Occurring Tumors of Companion Animals as Models for Human Cancer
Vail, D. M., & MacEwen, E. G. (2000) · Cancer Investigation · doi:10.3109/07357900009012210 · Cited by 533 · see citing works
Khanna, C., Lindblad‐Toh, K., Vail, D. M., London, C. A., Bergman, P. J., Barber, L. G., Breen, M., Kitchell, B. E., McNeil, E., Modiano, J. F., et al. (2006) · Nature Biotechnology · doi:10.1038/nbt0906-1065b · Cited by 342 · see citing works
A Review of Histiocytic Diseases of Dogs and Cats
Moore, P. F. (2014) · Veterinary Pathology · doi:10.1177/0300985813510413 · Cited by 310 · see citing works
Yin, Y., Boesteanu, A. C., Binder, Z. A., Xu, C. B., Reid, R. A., Rodriguez, J. L., Cook, D. R., Thokala, R., Blouch, K., McGettigan-Croce, B., et al. (2018) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2018.08.002 · Cited by 181 · see citing works
Mason, N. J., Gnanandarajah, J. S., Engiles, J. B., Gray, F., Laughlin, D., Gaurnier-Hausser, A., Wallecha, A., Huebner, M., & Paterson, Y. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0088 · Cited by 178 · see citing works
Thamm, D. H., Kurzman, I. D., King, I., Li, Z., Sznol, M., Dubielzig, R. R., Vail, D. M., & MacEwen, E. G. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2510 · Cited by 174 · see citing works
Use of FoxP3 expression to identify regulatory T cells in healthy dogs and dogs with cancer
Biller, B. J., Elmslie, R. E., Burnett, R. C., Avery, A. C., & DOW, S. W. (2006) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2006.12.002 · Cited by 159 · see citing works
Self-citationCanine mammary tumors as a model for human disease (Review)
Abdelmegeed, S., & Mohammed, S. I. (2018) · Oncology Letters · doi:10.3892/ol.2018.8411 · Cited by 158 · see citing works
Perspectives from man’s best friend: National Academy of Medicine’s Workshop on Comparative Oncology
LeBlanc, A. K., Breen, M., Choyke, P., Dewhirst, M., Fan, T. M., Gustafson, D. L., Helman, L. J., Kastan, M. B., Knapp, D. W., Levin, W. J., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf0746 · Cited by 147 · see citing works
Kurzman, I. D., MacEwen, E. G., ROSENTHAL, R. C., Fox, L. E., Keller, E. T., Helfand, S. C., Vail, D. M., Dubielzig, R. R., Madewell, B. R., & Rodriguez, C. O. (1995) · PubMed · Cited by 142 · see citing works
Domestic Dogs and Cancer Research: A Breed-Based Genomics Approach
Davis, B. W., & Ostrander, E. A. (2014) · ILAR Journal · doi:10.1093/ilar/ilu017 · Cited by 137 · see citing works
Panjwani, M. K., Smith, J. B., Schutsky, K., Gnanandarajah, J. S., O'Connor, C. M., Powell, D. J., & Mason, N. J. (2016) · Molecular Therapy · doi:10.1038/mt.2016.146 · Cited by 129 · see citing works
DOW, S. W., Elmslie, R. E., Willson, A. P., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci510 · Cited by 127 · see citing works
Self-citationCanter, R. J., Grossenbacher, S. K., Foltz, J. A., Sturgill, I. R., Park, J. S., Luna, J. I., Kent, M. S., Culp, W. T. N., Chen, M., Modiano, J. F., et al. (2017) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-017-0305-7 · Cited by 127 · see citing works
Paoloni, M. C., & Khanna, C. (2007) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2007.08.003 · Cited by 124 · see citing works
Canine cancer immunotherapy studies: linking mouse and human
Park, J. S., Withers, S. S., Modiano, J. F., Kent, M. S., Chen, M., Luna, J. I., Culp, W. T. N., Sparger, E. E., Rebhun, R. B., Monjazeb, A. M., et al. (2016) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-016-0200-7 · Cited by 121 · see citing works
Elvers, I., Turner-Maier, J., Swofford, R., Koltookian, M., Johnson, J., Stewart, C., Zhang, C.-Z., Schumacher, S. E., Beroukhim, R., Rosenberg, M. W., et al. (2015) · Genome Research · doi:10.1101/gr.194449.115 · Cited by 119 · see citing works
Paoloni, M. C., Tandle, A. T., Mazcko, C. N., Hanna, E., Kachala, S. S., LeBlanc, A. K., Newman, S. J., Vail, D. M., Henry, C. J., Thamm, D. H., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004972 · Cited by 118 · see citing works
MacEwen, E. G., Kurzman, I. D., Vail, D. M., Dubielzig, R. R., Everlith, K. M., Madewell, B. R., Rodriguez, C. O., Phillips, B., Zwahlen, C. H., Obradovich, J. E., et al. (1999) · PubMed · Cited by 115 · see citing works
Guiding the Optimal Translation of New Cancer Treatments From Canine to Human Cancer Patients
Khanna, C., London, C. A., Vail, D. M., Mazcko, C. N., & Hirschfeld, S. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0719 · Cited by 109 · see citing works
Monjazeb, A. M., Kent, M. S., Grossenbacher, S. K., Minnar, C. M., Zamora, A. E., Mirsoian, A., Chen, M., Kol, A., Shiao, S. L., Reddy, A., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-3026 · Cited by 108 · see citing works
Biller, B. J., Guth, A., Burton, J. H., & DOW, S. W. (2010) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2010.0557.x · Cited by 100 · see citing works
Self-citationHartley, G. P., Regan, D. P., Guth, A., & DOW, S. W. (2017) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-017-1955-5 · Cited by 95 · see citing works
Self-citationCompanion animals in comparative oncology: One Medicine in action
Garden, O. A., Volk, S. W., Mason, N. J., & Perry, J. A. (2018) · The Veterinary Journal · doi:10.1016/j.tvjl.2018.08.008 · Cited by 93 · see citing works
Changes in Regulatory T Cells in Dogs with Cancer and Associations with Tumor Type
O'Neill, K., Guth, A., Biller, B. J., et al. (2009) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2009.0333.x · Cited by 90 · see citing works
CCR4 Blockade Depletes Regulatory T Cells and Prolongs Survival in a Canine Model of Bladder Cancer
Maeda, S., Murakami, K., Inoue, A., Yonezawa, T., & Matsuki, N. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0751 · Cited by 89 · see citing works
Modeling Tumor Immunology and Immunotherapy in Mice
Buqué, A., & Galluzzi, L. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.07.003 · Cited by 88 · see citing works
Dhawan, D., Paoloni, M. C., Shukradas, S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136688 · Cited by 85 · see citing works
Comparative functional characterization of canine IgG subclasses
Bergeron, L. M., McCandless, E. E., Dunham, S. A., Dunkle, B., Zhu, Y., Shelly, J. A., Lightle, S., Gonzales, A. J., & Bainbridge, G. (2013) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2013.10.018 · Cited by 79 · see citing works
Humanized Mouse Models for the Preclinical Assessment of Cancer Immunotherapy
Wege, A. K. (2018) · BioDrugs · doi:10.1007/s40259-018-0275-4 · Cited by 78 · see citing works
Immune regulation of canine tumour and macrophage PD‐L1 expression
Hartley, G. P., Faulhaber, E. A., Caldwell, A. B., Coy, J., Kurihara, J. N., Guth, A., Regan, D. P., & DOW, S. W. (2016) · Veterinary and Comparative Oncology · doi:10.1111/vco.12197 · Cited by 75 · see citing works
Self-citationRegan, D. P., Coy, J. W., Chahal, K. K., Chow, L., Kurihara, J. N., Guth, A., Kufareva, I., & DOW, S. W. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800619 · Cited by 74 · see citing works
Self-citationA Vaccine Targeting Telomerase Enhances Survival of Dogs Affected by B-cell Lymphoma
Peruzzi, D., Gavazza, A., Mesiti, G., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.104 · Cited by 71 · see citing works
Friedrichs, K. R., & Young, K. M. (2008) · Veterinary Clinical Pathology · doi:10.1111/j.1939-165x.2008.00005.x · Cited by 69 · see citing works
PD ‐1 expression by canine T cells and functional effects of PD ‐1 blockade
Coy, J., Caldwell, A. B., Chow, L., Guth, A., & DOW, S. W. (2017) · Veterinary and Comparative Oncology · doi:10.1111/vco.12294 · Cited by 69 · see citing works
Self-citationCancer immunotherapy in veterinary medicine: Current options and new developments
Regan, D. P., Guth, A., Coy, J. W., et al. (2015) · The Veterinary Journal · doi:10.1016/j.tvjl.2015.10.008 · Cited by 68 · see citing works
Canine Cancer Genomics: Lessons for Canine and Human Health
Ostrander, E. A., Dreger, D. L., & Evans, J. M. (2018) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-030117-014523 · Cited by 67 · see citing works
Evaluation of a Novel Tumor Vaccine in Dogs with Hemangiosarcoma
U’Ren, L., Biller, B. J., Elmslie, R. E., et al. (2007) · Journal of Veterinary Internal Medicine · doi:10.1892/0891-6640(2007)21[113:eoantv]2.0.co;2 · Cited by 65 · see citing works
Paoloni, M. C., Mazcko, C. N., Selting, K. A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129954 · Cited by 63 · see citing works
Naturally occurring cancers in pet dogs as pre-clinical models for cancer immunotherapy
Tarone, L., Barutello, G., Iussich, S., Giacobino, D., Quaglino, E., Buracco, P., Cavallo, F., & Riccardo, F. (2019) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-019-02360-6 · Cited by 56 · see citing works
Andersen, B. M., Pluhar, G. E., Seiler, C. E., Goulart, M. R., SantaCruz, K. S., Schutten, M. M., Meints, J. P., O’Sullivan, M. G., Bentley, R. T., Packer, R. A., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3366 · Cited by 51 · see citing works
Immunotherapy for Dogs: Running Behind Humans
Klingemann, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00133 · Cited by 51 · see citing works
Foltz, J. A., Somanchi, S. S., Yang, Y., Aquino‐López, A., Bishop, E. E., & Lee, D. A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00521 · Cited by 49 · see citing works
Naturally Occurring Canine Glioma as a Model for Novel Therapeutics
Hubbard, M. E., Arnold, S. A., Zahid, A. B., McPheeters, M. J., O’Sullivan, M. G., Tăbăran, F., Hunt, M. A., & Pluhar, G. E. (2018) · Cancer Investigation · doi:10.1080/07357907.2018.1514622 · Cited by 40 · see citing works
A Review of Immunotherapeutic Strategies in Canine Malignant Melanoma
Almela, R. M., & Ansón, A. (2019) · Veterinary Sciences · doi:10.3390/vetsci6010015 · Cited by 37 · see citing works
New Treatment Modalities for Brain Tumors in Dogs and Cats
Rossmeisl, J. H. (2014) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2014.07.003 · Cited by 36 · see citing works
Wheat, W. H., Chow, L., Kurihara, J. N., et al. (2016) · Stem Cells and Development · doi:10.1089/scd.2016.0199 · Cited by 36 · see citing works
Checkpoint molecule expression by B and T cell lymphomas in dogs
Hartley, G. P., Elmslie, R. E., DOW, S. W., & Guth, A. (2018) · Veterinary and Comparative Oncology · doi:10.1111/vco.12386 · Cited by 35 · see citing works
Self-citationMilner, R. J., Salute, M. E., Crawford, C., Abbot, J. R., & Farese, J. P. (2006) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2006.08.012 · Cited by 33 · see citing works
Lee, S.-H., Shin, D., Kim, Y., Kim, C.-J., Lee, J., Yoon, M. S., Uong, T. N. T., Yu, D., Jung, J., Cho, D., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00841 · Cited by 33 · see citing works
FoxP3 and IDO in Canine Melanocytic Tumors
Porcellato, I., Brachelente, C., Paolis, L. D., Menchetti, L., Silvestri, S., Sforna, M., Vichi, G., Iussich, S., & Mechelli, L. (2018) · Veterinary Pathology · doi:10.1177/0300985818808530 · Cited by 32 · see citing works
Liposomal clodronate treatment for tumour macrophage depletion in dogs with soft‐tissue sarcoma
Guth, A., Hafeman, S., Elmslie, R. E., & DOW, S. W. (2012) · Veterinary and Comparative Oncology · doi:10.1111/j.1476-5829.2012.00319.x · Cited by 29 · see citing works
Self-citationCoomer, A. R., & Liptak, J. M. (2008) · PubMed · Cited by 29 · see citing works
Cellular Immunotherapy of Canine Cancer
Addissie, S., & Klingemann, H. (2018) · Veterinary Sciences · doi:10.3390/vetsci5040100 · Cited by 28 · see citing works
Bridging the Gap Between Experimental Animals and Humans in Osteosarcoma
Withrow, S. J., & Khanna, C. (2009) · Cancer treatment and research · doi:10.1007/978-1-4419-0284-9_24 · Cited by 27 · see citing works
Developing T cell cancer immunotherapy in the dog with lymphoma.
O'Connor, C., & Wilson-Robles, H. (2014) · ILAR journal · doi:10.1093/ilar/ilu020 · Cited by 24 · see citing works
Role of monocyte recruitment in hemangiosarcoma metastasis in dogs
Regan, D. P., Escaffi, A., Coy, J., Kurihara, J. N., & DOW, S. W. (2016) · Veterinary and Comparative Oncology · doi:10.1111/vco.12272 · Cited by 22 · see citing works
Self-citationDevelopment and characterization of a canine-specific anti-CD94 (KLRD-1) monoclonal antibody
Graves, S. S., Gyurkocza, B., Stone, D. M., et al. (2019) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2019.03.005 · Cited by 21 · see citing works
Olin, M. R., Pluhar, G. E., Andersen, B. M., Shaver, R. L., Waldron, N. N., & Moertel, C. L. (2014) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2014011577 · Cited by 18 · see citing works
A DNA telomerase vaccine for canine cancer immunotherapy
Thalmensi, J., Pliquet, É., Liard, C., et al. (2019) · Oncotarget · doi:10.18632/oncotarget.26927 · Cited by 18 · see citing works
Manipulation of Innate Immunity for Cancer Therapy in Dogs
Regan, D. P., & DOW, S. W. (2015) · Veterinary Sciences · doi:10.3390/vetsci2040423 · Cited by 17 · see citing works
Self-citationGamma delta T‐cell large granular lymphocyte lymphoma in a dog
Ortiz, A. L., Carvalho, S., Leo, C., et al. (2015) · Veterinary Clinical Pathology · doi:10.1111/vcp.12265 · Cited by 16 · see citing works
Catching Cancer by the Tail: New Perspectives on the Use of Kinase Inhibitors
Khanna, C., & Gordon, I. K. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0132 · Cited by 16 · see citing works
Guth, A., Hafeman, S., & DOW, S. W. (2012) · OncoImmunology · doi:10.4161/onci.21317 · Cited by 10 · see citing works
Self-citationChen, H.-W., Small, G. W., Motsinger‐Reif, A. A., et al. (2013) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2013.10.020 · Cited by 9 · see citing works
Immunotherapy for canine cancer – Is it time to go back to the future?
Killick, D. R., Stell, A.-V., & Catchpole, B. (2015) · Journal of Small Animal Practice · doi:10.1111/jsap.12336 · Cited by 9 · see citing works
Immunotherapy in Veterinary Oncology
Bergman, P. J. (2014) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2014.05.002 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Beird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00409-y · Cited by 660 · see citing works
- Authors
- Dow, S.
- Affiliations
- Colorado State University (US)
- Corresponding author
- Dow, Steven
- ORCID
- Dow, Steven
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2020-01-17
- Volume
- 10
- Pages
- 2935-2935
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC6979257
- OpenAlex
- W2999814752
- Cited by
- 110
- References
- 68
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 15 · 2023: 21 · 2022: 14 · 2021: 23 · 2020: 5 · 2018: 2
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Veterinary Oncology Research
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Keywords
- cancer immunotherapy, animal models, drug combination therapy, translational research, canine cancer
- MeSH terms
- Animals, Disease Models, Animal, Dog Diseases, Dogs, Humans, Immunotherapy, Neoplasms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
