The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Phagocytosis of Apoptotic Cells in Resolution of Inflammation
Open accessAbstract
Efficient inflammation resolution is important not only for the termination of the inflammatory response but also for the restoration of tissue integrity. An integral process to resolution of inflammation is the phagocytosis of dying cells by macrophages, known as efferocytosis. This function is mediated by a complex and well-orchestrated network of interactions amongst specialized phagocytic receptors, bridging molecules, as well as "find-me" and "eat-me" signals. Efferocytosis serves not only as a waste disposal mechanism (clearance of the apoptotic cells) but also promotes a pro-resolving phenotype in efferocytic macrophages and thereby termination of inflammation. Alterations in cellular metabolism are critical for shaping the phenotype and function of efferocytic macrophages, thus, representing an important determinant of macrophage plasticity. Impaired efferocytosis can result in inflammation-associated pathologies or autoimmunity. The present mini review summarizes current knowledge regarding the mechanisms regulating macrophage efferocytosis during clearance of inflammation.
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Cites
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Hammerich, L., & Tacke, F. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00807-x · Cited by 803
The Immune Functions of Keratinocytes in Skin Wound Healing
Piipponen, M., Li, D., & Landén, N. X. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228790 · Cited by 503
Akkız, H., Gieseler, R. K., & Canbay, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147873 · Cited by 191
Role of Neutrophils in the Pathogenesis of Nonalcoholic Steatohepatitis
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The ABCA1-efferocytosis axis: A new strategy to protect against atherosclerosis
Chen, W., Li, L., Wang, J., Zhang, R., Zhang, T., Wu, Y., Wang, S., & Xing, D. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.02.025 · Cited by 84
Metadata
- Authors
- Kourtzelis, I., Hajishengallis, G., & Chavakis, T.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2020-03-31
- Volume
- 11
- Pages
- 553-553
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W3014808794
- Cited by
- 300
- References
- 116
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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