The DOI matches its Crossref record; 175 of the 175 references it cites were found in a registry or an index.
The Immune Functions of Keratinocytes in Skin Wound Healing
Open accessAbstract
As the most dominant cell type in the skin, keratinocytes play critical roles in wound repair not only as structural cells but also exerting important immune functions. This review focuses on the communications between keratinocytes and immune cells in wound healing, which are mediated by various cytokines, chemokines, and extracellular vesicles. Keratinocytes can also directly interact with T cells via antigen presentation. Moreover, keratinocytes produce antimicrobial peptides that can directly kill the invading pathogens and contribute to wound repair in many aspects. We also reviewed the epigenetic mechanisms known to regulate keratinocyte immune functions, including histone modifications, non-protein-coding RNAs (e.g., microRNAs, and long noncoding RNAs), and chromatin dynamics. Lastly, we summarized the current evidence on the dysregulated immune functions of keratinocytes in chronic nonhealing wounds. Based on their crucial immune functions in skin wound healing, we propose that keratinocytes significantly contribute to the pathogenesis of chronic wound inflammation. We hope this review will trigger an interest in investigating the immune roles of keratinocytes in chronic wound pathology, which may open up new avenues for developing innovative wound treatments.
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A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491
Regulation of chromatin by histone modifications
Bannister, A. J., & Kouzarides, T. (2011) · Cell Research · doi:10.1038/cr.2011.22 · Cited by 6,012
Long non-coding RNAs: insights into functions
Mercer, T. R., Dinger, M. E., & Mattick, J. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2521 · Cited by 5,654
Mathieu, M., Martin-Jaular, L., Lavieu, G., & Théry, C. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0250-9 · Cited by 3,737
Toll-Like Receptor Signaling Pathways
Kawasaki, T., & Kawai, T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00461 · Cited by 3,233
Long non-coding RNAs: new players in cell differentiation and development
Fatica, A., & Bozzoni, I. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3606 · Cited by 2,980
Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.157 · Cited by 2,806
Trained immunity: A program of innate immune memory in health and– disease
Netea, M. G., Joosten, L. A. B., Latz, E., Mills, K. H. G., Natoli, G., Stunnenberg, H. G., O’Neill, L. A. J., & Xavier, R. J. (2016) · Science · doi:10.1126/science.aaf1098 · Cited by 2,768
Transition from inflammation to proliferation: a critical step during wound healing
Landén, N. X., Li, D., & Ståhle, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2268-0 · Cited by 1,980
Self-citationKrzyszczyk, P., Schloss, R., Palmer, A., & Berthiaume, F. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00419 · Cited by 1,546
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Immunology of Acute and Chronic Wound Healing
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Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing
Zhou, C., Zhang, B., Yang, Y., Jiang, Q., Li, T., Gong, J., Tang, H., & Zhang, Q. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03345-0 · Cited by 341
Fernandes, A., Rodrigues, P. M., Pintado, M., & Tavaria, F. K. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154824 · Cited by 264
Modeling of solar UV-induced photodamage on the hair follicles in human skin organoids
Kim, M.-J., Ahn, H.-J., Kong, D., Lee, S., Kim, D.-H., & Kang, K.-S. (2024) · Journal of Tissue Engineering · doi:10.1177/20417314241248753 · Cited by 25
In Vitro and Ex Vivo Models for Screening Topical Anti-Inflammatory Drugs
Pérez-Salas, J. L., Moreno-Jiménez, M. R., Rocha-Guzmán, N. E., González-Laredo, R. F., Medina-Torres, L., & Gallegos-Infante, J. A. (2023) · Scientia Pharmaceutica · doi:10.3390/scipharm91020020 · Cited by 22
Metadata
- Authors
- Piipponen, M., Li, D., & Landén, N. X.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-11-20
- Volume
- 21
- Issue
- 22
- Pages
- 8790
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3105715144
- Cited by
- 503
- References
- 175
- FWCI
- 18.69
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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