Cited by 398Gut microbiota and healthProbiotics and Fermented FoodsGastrointestinal motility and disorders

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Intestinal Flora and Disease Mutually Shape the Regional Immune System in the Intestinal Tract

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Zhou, Bolun, Yuan, Yutong, Zhang, Shanshan, Guo, Can, Li, Xiaoling, Li, Guiyuan, Xiong, Wei, Zeng, Zhaoyang·2020·Frontiers in Immunology

DOI 10.3389/fimmu.2020.00575PMC PMC7147503

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Abstract

. To protect the body from potential pathogens, the intestinal tract has evolved regional immune characteristics. These characteristics are defined by its unique structure, function, and microenvironment, which differ drastically from those of the common central and peripheral immune organs. The intestinal microenvironment created by the intestinal flora and its products significantly affects the immune function of the region. In turn, specific diseases regulate and influence the composition of the intestinal flora. A constant interplay occurs between the intestinal flora and immune system. Further, the intestinal microenvironment can be reconstructed by probiotic use or microbiota transplantation, functioning to recalibrate the immune homeostasis, while also contributing to the treatment or amelioration of diseases. In this review, we summarize the relationship between the intestinal flora and the occurrence and development of diseases as an in-turn effect on intestinal immunity. We also discuss improved immune function as it relates to non-specific and specific immunity. Further, we discuss the proliferation, differentiation and secretion of immune cells, within the intestinal region following remodeling of the microenvironment as a means to ameliorate and treat diseases. Finally, we suggest strategies for improved utilization of intestinal flora.

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Additional file 5 of Putative causal relations among gut flora, serums metabolites and arrhythmia: a Mendelian randomization study
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Additional file 4 of Putative causal relations among gut flora, serums metabolites and arrhythmia: a Mendelian randomization study
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Additional file 8 of Putative causal relations among gut flora, serums metabolites and arrhythmia: a Mendelian randomization study
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Additional file 12 of Putative causal relations among gut flora, serums metabolites and arrhythmia: a Mendelian randomization study
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Additional file 6 of Putative causal relations among gut flora, serums metabolites and arrhythmia: a Mendelian randomization study
Li, K., Liu, P., Liu, M., Ye, J., & Zhu, L. (2024) · Figshare · doi:10.6084/m9.figshare.26666383
Additional file 7 of Putative causal relations among gut flora, serums metabolites and arrhythmia: a Mendelian randomization study
Li, K., Liu, P., Liu, M., Ye, J., & Zhu, L. (2024) · Figshare · doi:10.6084/m9.figshare.26666386
Additional file 13 of Putative causal relations among gut flora, serums metabolites and arrhythmia: a Mendelian randomization study
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Additional file 2 of Huangqi Guizhi Wuwu decoction alleviates oxaliplatin-induced peripheral neuropathy via the gut-peripheral nerve axis
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Additional file 10 of Putative causal relations among gut flora, serums metabolites and arrhythmia: a Mendelian randomization study
Li, K., Liu, P., Liu, M., Ye, J., & Zhu, L. (2024) · Figshare · doi:10.6084/m9.figshare.26666395
Additional file 2 of Putative causal relations among gut flora, serums metabolites and arrhythmia: a Mendelian randomization study
Li, K., Liu, P., Liu, M., Ye, J., & Zhu, L. (2024) · Figshare · doi:10.6084/m9.figshare.24987927
Additional file 9 of Putative causal relations among gut flora, serums metabolites and arrhythmia: a Mendelian randomization study
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Additional file 11 of Putative causal relations among gut flora, serums metabolites and arrhythmia: a Mendelian randomization study
Li, K., Liu, P., Liu, M., Ye, J., & Zhu, L. (2024) · Figshare · doi:10.6084/m9.figshare.26666398
Additional file 3 of Putative causal relations among gut flora, serums metabolites and arrhythmia: a Mendelian randomization study
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Self-citation
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Authors: Zhou, B., Yuan, Y., Zhang, S., Guo, C., Li, X., Li, G., Xiong, W., & Zeng, Z.
Affiliations: Central South University (CN)
Corresponding author: Zeng, Zhaoyang
ORCID: Zhou, Bolun
Yuan, Yutong
Guo, Can
Li, Xiaoling
Li, Guiyuan
Xiong, Wei
Zeng, Zhaoyang
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2020-04-03
Volume: 11
Pages: 575-575
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2020.00575
PMC: PMC7147503
OpenAlex: W3014654467
Cited by: 396
References: 122
Citations by year: 2026: 41 · 2025: 103 · 2024: 114 · 2023: 70 · 2022: 47 · 2021: 16 · 2020: 3
FWCI: 3.25
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Immunology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81672993, 81702907, 81772928, 81803025)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: gut microbiota, intestinal immunity, regional immunity, intestinal microenvironment, immune homeostasis, probiotics, microbiota transplantation, innate immunity, adaptive immunity, immune cell differentiation, immune cell proliferation
MeSH terms: Gastrointestinal Microbiome, Animals, Humans, Intestinal Mucosa, Immunity, Mucosal

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Intestinal Flora and Disease Mutually Shape the Regional Immune System in the Intestinal Tract

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