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Cited by 63Immune Cell Function and InteractionInflammation biomarkers and pathwaysNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Leukocyte Immunoglobulin-Like Receptors (LILRs) on Human Neutrophils: Modulators of Infection and Immunity

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Lewis Marffy, Alexander L., McCarthy, Alex J.·2020·Frontiers in Immunology
DOI 10.3389/fimmu.2020.00857PMC PMC7237751
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Abstract

Neutrophils have a crucial role in defense against microbes. Immune receptors allow neutrophils to sense their environment, with many receptors functioning to recognize signs of infection and to promote antimicrobial effector functions. However, the neutrophil response must be tightly regulated to prevent excessive inflammation and tissue damage, and regulation is achieved by expression of inhibitory receptors that can raise activation thresholds. The leukocyte immunoglobulin-like receptor (LILR) family contain activating and inhibitory members that can up- or down-regulate immune cell activity. New ligands and functions for LILR continue to emerge. Understanding the role of LILR in neutrophil biology is of general interest as they can activate and suppress antimicrobial responses of neutrophils and because several human pathogens exploit these receptors for immune evasion. This review focuses on the role of LILR in neutrophil biology. We focus on the current knowledge of LILR expression on neutrophils, the known functions of LILR on neutrophils, and how these receptors may contribute to shaping neutrophil responses during infection.

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  1. [1]Mócsai A. Diverse novel functions of neutrophils in immunity, inflammation, and beyond. J Exp Med. (2013) 210: 1289– 99. 10.1084/jem.20122220 23825232 PMC3698517 · DOI
  2. [2]Amulic B Cazalet C Hayes GL Metzler KD Zychlinsky A. Neutrophil function: from mechanisms to disease. Annu Rev Immunol. (2012) 30: 459– 89. 10.1146/annurev-immunol-020711-074942 22224774 · DOI
  3. [3]Tecchio C Micheletti A Cassatella MA. Neutrophil-derived cytokines: facts beyond expression. Front Immunol. (2014) 5: 508. 10.3389/fimmu.2014.00508 25374568 PMC4204637 · DOI · Paper page
  4. [4]Newburger PE Subrahmanyam Y Weissman SM. Global analysis of neutrophil gene expression. Curr Opin Hematol. (2000) 7: 16– 20. 10.1097/00062752-200001000-00004 10608499 · DOI
  5. [5]Scapini P Marini O Tecchio C Cassatella MA. Human neutrophils in the saga of cellular heterogeneity: insights and open questions. Immunol Rev. (2016) 273: 48– 60. 10.1111/imr.12448 27558327 · DOI
  6. [6]Scapini P Cassatella MA. Social networking of human neutrophils within the immune system. Blood. (2014) 124: 710– 9. 10.1182/blood-2014-03-453217 24923297 · DOI
  7. [7]Lee W Kang J Yan J Lee M Jeon B Cho S. Neutrophils promote mycobacterial trehalose dimycolate-induced lung inflammation via the mincle pathway. PLoS Pathogens. (2012) 8: e1002614. 10.1371/journal.ppat.1002614 22496642 PMC3320589 · DOI
  8. [8]Lu X Nagata M Yamasaki S. Mincle: 20 years of a versatile sensor of insults. Int Immunol. (2018) 30: 233– 9. 10.1093/intimm/dxy028 29726997 · DOI
  9. [9]Sharma A Steichen AL Jondle CN Mishra BB Sharma J. Protective role of mincle in bacterial pneumonia by regulation of neutrophil mediated phagocytosis and extracellular trap formation. J Infect Dis. (2014) 209: 1837– 46. 10.1093/infdis/jit820 24353272 PMC4017361 · DOI
  10. [10]Futosi K Fodor S Mócsai A Neutrophil cell surface receptors and their intracellular signal transduction pathways. Int Immunopharmacol. (2013) 17: 638– 50. 10.1016/j.intimp.2013.06.034 23994464 PMC3827506 · DOI · Paper page
  11. [11]Ali SR Fong JJ Carlin AF Busch TD Linden R Angata T. Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. J Exp Med. (2014) 211: 1231– 42. 10.1084/jem.20131853 24799499 PMC4042635 · DOI
  12. [12]Schmitter T Agerer F Peterson L Münzner P Hauck CR. Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens. J Exp Med. (2004) 199: 35– 46. 10.1084/jem.20030204 14707113 PMC1887732 · DOI
  13. [13]Favier B. Regulation of neutrophil functions through inhibitory receptors: an emerging paradigm in health and disease. Immunol Rev. (2016) 273: 140– 55. 10.1111/imr.12457 27558333 · DOI
  14. [14]Verbrugge A de Ruiter T Geest C Coffer PJ Meyaard L. Differential expression of leukocyte-associated Ig-like receptor-1 during neutrophil differentiation and activation. J Leukocyte Biol. (2006) 79: 828– 36. 10.1189/jlb.0705370 16461736 · DOI
  15. [15]Steevels TAM Lebbink RJ Westerlaken GHA Coffer PJ Meyaard L. Signal inhibitory receptor on leukocytes-1 is a novel functional inhibitory immune receptor expressed on human phagocytes. J Immunol. (2010) 184: 4741– 8. 10.4049/jimmunol.0902039 20375307 · DOI
  16. [16]Avril T Freeman SD Attrill H Clarke RG Crocker PR. Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. J Biol Chem. (2005) 280: 19843– 51. 10.1074/jbc.M502041200 15769739 · DOI
  17. [17]Zhao Y van Woudenbergh E Zhu J Heck AJR van Kessel KPM de Haas CJC. The orphan immune receptor LILRB3 modulates Fc receptor-mediated functions of neutrophils. J Immunol. (2020) 204: 954– 66. 10.4049/jimmunol.1900852 31915259 PMC7617070 · DOI
  18. [18]Kuespert K Pils S Hauck CR. CEACAMs: their role in physiology and pathophysiology. Curr Opin Cell Biol. (2006) 18: 565– 71. 10.1016/j.ceb.2006.08.008 16919437 PMC7127089 · DOI
  19. [19]Willcox BE Thomas LM Bjorkman PJ. Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor. Nat Immunol. (2003) 4: 913– 9. 10.1038/ni961 12897781 · DOI
  20. [20]Torkar M Haude A Milne S Beck S Trowsdale J Wilson MJ. Arrangement of the ILT gene cluster: a common null allele of the ILT6 gene results from a 6.7-kbp deletion. Eur J Immunol. (2000) 30: 3655– 62. 10.1002/1521-4141(200012)30:12<3655::AID-IMMU3655>3.0.CO;2-Y 11169408 · DOI
  21. [21]Young NT Canavez F Uhrberg M Shum BP Parham P. Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex. Immunogenetics. (2001) 53: 270– 8. 10.1007/s002510100332 11491530 · DOI
  22. [22]Bashirova AA Apps R Vince N Mochalova Y Yu XG Carrington M. Diversity of the human LILRB3/A6 locus encoding a myeloid inhibitory and activating receptor pair. Immunogenetics. (2014) 66: 1– 8. 10.1007/s00251-013-0730-9 24096970 PMC3877738 · DOI
  23. [23]Tedla N Gibson K McNeil HP Cosman D Borges L Arm JP. The co-expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium. Am J Pathol. (2002) 160: 425– 31. 10.1016/S0002-9440(10)64861-4 11839562 PMC1850658 · DOI
  24. [24]Jones DC Roghanian A Brown DP Chang C Allen RL Trowsdale J. Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes. Eur J Immunol. (2009) 39: 3195– 206. 10.1002/eji.200839080 19658091 · DOI
  25. [25]Kubagawa H Burrows PD Cooper MD. A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Proc Natl Acad Sci U S A. (1997) 94: 5261– 6. 10.1073/pnas.94.10.5261 9144225 PMC24666 · DOI · Paper page
  26. [26]Zhou JS Friend DS Feldweg AM Daheshia M Li L Austen KF. Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils. J Exp Med. (2003) 198: 1243– 51. 10.1084/jem.20030906 14557414 PMC2194230 · DOI
  27. [27]Naji A Menier C Morandi F Agaugué S Maki G Ferretti E. Binding of HLA-G to ITIM-bearing Ig-like transcript 2 receptor suppresses B cell responses. J Immunol. (2014) 192: 1536– 46. 10.4049/jimmunol.1300438 24453251 · DOI
  28. [28]Bléry M Kubagawa H Chen C-C Vély F Cooper MD Vivier E. The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1. Proc Natl Acad Sci U S A. (1998) 95: 2446– 51. 10.1073/pnas.95.5.2446 9482905 PMC19370 · DOI
  29. [29]Colonna M Navarro F Bellón T Llano M García P Samaridis J. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J Exp Med. (1997) 186: 1809– 18. 10.1084/jem.186.11.1809 9382880 PMC2199153 · DOI
  30. [30]Dietrich J Cella M Colonna M. Ig-like transcript 2 (ILT2)/leukocyte Ig-like receptor 1 (LIR1) inhibits TCR signaling and actin cytoskeleton reorganization. J Immunol. (2001) 166: 2514– 21. 10.4049/jimmunol.166.4.2514 11160312 · DOI
  31. [31]Baudhuin J Migraine J Faivre V Loumagne L Lukaszewicz AC Payen D. Exocytosis acts as a modulator of the ILT4-mediated inhibition of neutrophil functions. Proc Natl Acad Sci U S A. (2013) 110: 17957– 62. 10.1073/pnas.1221535110 24133137 PMC3816409 · DOI
  32. [32]Cao W Rosen DB Ito T Bover L Bao M Watanabe G Lanier and Y-JL. Plasmacytoid dendritic cell-specific receptor ILT7-FcεRIγ inhibits Toll-like receptor-induced interferon production. J Exp Med. (2006) 203: 1399– 405. 10.1084/jem.20052454 16735691 PMC2118323 · DOI
  33. [33]Lu HK Mitchell A Endoh Y Hampartzoumian T Huynh O Borges L. LILRA2 selectively modulates LPS-mediated cytokine production and inhibits phagocytosis by monocytes. PLoS One. (2012) 7: e33478. 10.1371/journal.pone.0033478 22479404 PMC3316576 · DOI
  34. [34]Cao W Bover L Cho M Wen X Hanabuchi S Bao M. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med. (2009) 206: 1603– 14. 10.1084/jem.20090547 19564354 PMC2715090 · DOI
  35. [35]Brown DP Jones DC Anderson KJ Lapaque N Buerki RA Trowsdale J. The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection. BMC Immunol. (2009) 10: 56. 10.1186/1471-2172-10-56 19860908 PMC2773765 · DOI
  36. [36]Nakayama M Underhill DM Petersen TW Li B Kitamura T Takai T. Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production. J Immunol. (2007) 178: 4250– 9. 10.4049/jimmunol.178.7.4250 17371981 · DOI
  37. [37]Jones DC Kosmoliaptsis V Apps R Lapaque N Smith I Kono A. HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding. J Immunol. (2011) 186: 2990– 7. 10.4049/jimmunol.1003078 21270408 · DOI
  38. [38]Hogan LE Jones DC Allen RL. Expression of the innate immune receptor LILRB5 on monocytes is associated with mycobacteria exposure. Sci Rep. (2016) 6: 21780. 10.1038/srep21780 26908331 PMC4764857 · DOI
  39. [39]Tedla N Bandeira-Melo C Tassinari P Sloane DE Samplaski M Cosman D. Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. Proc Natl Acad Sci U S A. (2002) 100: 1174– 9. 10.1073/pnas.0337567100 12529506 PMC298746 · DOI
  40. [40]Chen Y Gao F Chu F Peng H Zong L Liu Y. Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes. J Mol Biol. (2009) 386: 841– 53. 10.1016/j.jmb.2009.01.006 19230061 · DOI
  41. [41]Hirayasu K Saito F Suenaga T Shida K Arase N Oikawa K. Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2. Nat Microbiol. (2016) 1: 16054. 10.1038/nmicrobiol.2016.54 27572839 · DOI
  42. [42]Colonna M Nakajima H Samaridis J Angman L Chain γ associates with Fc receptor an activating ILT receptor (ILT1) that cutting edge: human myeloid cells express. J Immunol. (1999) 162: 5– 8. 9886363
  43. [43]Grabowski P Hesse S Hollizeck S Rohlfs M Behrends U Sherkat R. Proteome analysis of human neutrophil granulocytes from patients with monogenic disease using data-independent acquisition. Mol Cell Proteomics. (2019) 18: 760– 72. 10.1074/mcp.RA118.001141 30630937 PMC6442368 · DOI
  44. [44]Tak T Wijten P Heeres M Pickkers P Scholten A Heck AJR. Human CD62Ldim neutrophils identified as a separate subset by proteome profiling and in vivo pulse-chase labeling. Blood. (2017) 129: 3476– 85. 10.1182/blood-2016-07-727669 28515092 · DOI
  45. [45]Kawashima Y Miyata J Watanabe T Shioya J Arita M Ohara O. Proteogenomic analyses of cellular lysates using a phenol-guanidinium thiocyanate reagent. J Proteome Res. (2019) 18: 301– 8. 10.1021/acs.jproteome.8b00609 30394753 · DOI
  46. [46]Hoogendijk AJ Pourfarzad F Aarts CEM Tool ATJ Hiemstra IH Grassi L. Dynamic transcriptome-proteome correlation networks reveal human myeloid differentiation and neutrophil-specific programming. Cell Rep. (2019) 29: 2505– 19.e4. 10.1016/j.celrep.2019.10.082 31747616 · DOI
  47. [47]Rieckmann JC Geiger R Hornburg D Wolf T Kveler K Jarrossay D. Social network architecture of human immune cells unveiled by quantitative proteomics. Nat Immunol. (2017) 18: 583– 93. 10.1038/ni.3693 28263321 · DOI
  48. [48]Borges L Kubin M Kuhlman T. LIR9, an immunoglobulin-superfamily-activating receptor, is expressed as a transmembrane and as a secreted molecule. Blood. (2003) 101: 1484– 6. 10.1182/blood-2002-05-1432 12393390 · DOI
  49. [49]Jones DC Hewitt CRA López-Álvarez MR Jahnke M Russell AI Radjabova V. Allele-specific recognition by LILRB3 and LILRA6 of a cytokeratin 8-associated ligand on necrotic glandular epithelial cells. Oncotarget. (2016) 7: 15618– 31. 10.18632/oncotarget.6905 26769854 PMC4941265 · DOI
  50. [50]Rørvig S Østergaard O Heegaard NHH Borregaard N. Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors. J Leukocyte Biol. (2013) 94: 711– 21. 10.1189/jlb.1212619 23650620 · DOI · Paper page
  51. [51]Cosman D Fanger N Borges L Kubin M Chin W Peterson L. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity. (1997) 7: 273– 82. 10.1016/S1074-7613(00)80529-4 9285411 · DOI
  52. [52]Saito F Hirayasu K Satoh T Wang CW Lusingu J Arimori T. Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors. Nature. (2017) 552: 101– 5. 10.1038/nature24994 29186116 PMC5748893 · DOI
  53. [53]Chan KR Ong EZ Tan HC Zhang SLX Zhang Q Tang KF. Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue. Proc Natl Acad Sci U S A. (2014) 111: 2722– 7. 10.1073/pnas.1317454111 24550301 PMC3932915 · DOI
  54. [54]Arnold V Cummings JS Moreno-Nieves UY Didier C Gilbert A Barré-Sinoussi F. S100A9 protein is a novel ligand for the CD85j receptor and its interaction is implicated in the control of HIV-1 replication by NK cells. Retrovirology. (2013) 10: 122. 10.1186/1742-4690-10-122 24156302 PMC3826667 · DOI
  55. [55]Bankey PE Banerjee S Zucchiatti A De M Sleem RW Lin CFL. Cytokine induced expression of programmed death ligands in human neutrophils. Immunol Lett. (2010) 129: 100– 7. 10.1016/j.imlet.2010.01.006 20123111 PMC2849642 · DOI
  56. [56]Pulford K Micklem K Thomas J Jones M Nuffield DYM. A 72-kD B cell-associated surface glycoprotein expressed at high levels in hairy cell leukaemia and plasma cell neoplasms. Clin Exp Immunol. (1991) 85: 429– 35. 10.1111/j.1365-2249.1991.tb05744.x 1893623 PMC1535601 · DOI
  57. [57]Stewart PA Welsh EA Slebos RJC Fang B Izumi V Chambers M. Proteogenomic landscape of squamous cell lung cancer. Nat Commun. (2019) 10: 3578. 31395880 PMC6687710
  58. [58]Tomazella GG Dasilva I Thomé CH Greene LJ Koehler CJ Thiede B. Analysis of detergent-insoluble and whole cell lysate fractions of resting neutrophils using high-resolution mass spectrometry. J Proteome Res. (2010) 9: 2030– 6. 10.1021/pr1000253 20158270 · DOI
  59. [59]Navarro F Llano M Bellón T Colonna M Geraghty DE López-Botet ML. The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells. Eur J Immunol. (1999) 29: 277– 83. 10.1002/(SICI)1521-4141(199901)29:01<277::AID-IMMU277>3.0.CO;2-4 9933109 · DOI
  60. [60]Lepin EJM Bastin JM Allan DSJ Roncador G Braud VM Mason DY. Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors. Eur J Immunol. (2000) 30: 3552– 61. 10.1002/1521-4141(200012)30:12<3552::AID-IMMU3552>3.0.CO;2-L 11169396 · DOI
  61. [61]Shiroishi M Kajikawa M Kuroki K Ose T Kohda D Maenaka K. Crystal structure of the human monocyte-activating receptor, “Group 2” leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11). J Biol Chem. (2006) 281: 19536– 544. 10.1074/jbc.M603076200 16675463 · DOI
  62. [62]Li D Hong A Lu Q Gao GF Jin B Screaton GR. A novel role of CD1c in regulating CD1d-mediated NKT cell recognition by competitive binding to Ig-like transcript 4. Int Immunol. (2012) 24: 729– 37. 10.1093/intimm/dxs082 22888216 · DOI
  63. [63]Zheng J Umikawa M Cui C Li J Chen X Zhang C. Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Nature. (2012) 485: 656– 60. 10.1038/nature11095 22660330 PMC3367397 · DOI
  64. [64]Li D Wang L Yu L Freundt EC Jin B Screaton GR Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction 1. J Immunol. (2009) 182: 1033– 40. 10.4049/jimmunol.182.2.1033 19124746 PMC2646168 · DOI
  65. [65]Atwal JK Pinkston-Gosse J Syken J Stawicki S Wu Y Shatz C. PirB is a functional receptor for myelin inhibitors of axonal regeneration. Science. 322: 967– 70. 10.1126/science.1161151 18988857 · DOI
  66. [66]Hofer J Forster F Isenman DE Wahrmann M Leitner J Hölzl MA. Ig-like transcript 4 as a cellular receptor for soluble complement fragment C4d. FASEB J. (2016) 30: 1492– 503. 10.1096/fj.15-275594 26678451 · DOI
  67. [67]Venet F Schilling J Cazalis MA Demaret J Poujol F Girardot T. Modulation of LILRB2 protein and mRNA expressions in septic shock patients and after ex vivo lipopolysaccharide stimulation. Hum Immunol. (2017) 78: 441– 50. 10.1016/j.humimm.2017.03.010 28341250 · DOI
  68. [68]Lominadze G Powell DW Luerman GC Link AJ Ward RA McLeish KR. Proteomic analysis of human neutrophil granules. Mol Cell Proteomics. (2005) 4: 1503– 21. 10.1074/mcp.M500143-MCP200 15985654 · DOI
  69. [69]Uriarte SM Powell DW Luerman GC Merchant ML Cummins TD Jog NR. Comparison of proteins expressed on secretory vesicle membranes and plasma membranes of human neutrophils. J Immunol. (2008) 180: 5575– 81. 10.4049/jimmunol.180.8.5575 18390742 · DOI
  70. [70]Cella M Döhring C Samaridis J Dessing M Brockhaus M Lanzavecchia A. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med. (1997) 185: 1743– 51. 10.1084/jem.185.10.1743 9151699 PMC2196312 · DOI
  71. [71]Chang CC Ciubotariu R Manavalan JS Yuan J Colovai AI Piazza F Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nat Immunol. (2002) 3: 237– 43. 10.1038/ni760 11875462 · DOI
  72. [73]An H Chandra V Piraino B Borges L Geczy C McNeil HP. Soluble LILRA3, a potential natural antiinflammatory protein, is increased in patients with rheumatoid arthritis and is tightly regulated by interleukin 10, tumor necrosis factor-alpha, and interferon-gamma. J Rheumatol. (2010) 37: 1596– 606. 10.3899/jrheum.091119 20595277 · DOI
  73. [74]Tedla N Lee C-W Borges L Geczy CL Arm JP. Differential expression of leukocyte immunoglobulin-like receptors on cord blood-derived human mast cell progenitors and mature mast cells. J Leukocyte Biol. (2008) 83: 334– 43. 10.1189/jlb.0507314 17998301 · DOI
  74. [75]Suciu-Foca N Feirt N Zhang Q-Y Vlad G Liu Z Lin H. Soluble Ig-like transcript 3 inhibits tumor allograft rejection in humanized SCID mice and T cell responses in cancer patients. J Immunol. (2007) 178: 7432– 41. 10.4049/jimmunol.178.11.7432 17513794 · DOI
  75. [76]Brezski R Jordan R. Cleavage of IgGs by proteases associated with invasive diseases: an evasion tactic against host immunity? MAbs. (2010) 2: 212– 20. 10.4161/mabs.2.3.11780 20400859 PMC2881249 · DOI
  76. [77]Chapman TL Heikema AP Bjorkman PJ. The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18. Immunity. (1999) 11: 603– 13. 10.1016/S1074-7613(00)80135-1 10591185 · DOI
  77. [78]Nakayama M Kurokawa K Nakamura K Lee BL Sekimizu K Kubagawa H. Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence. J Immunol. (2012) 189: 5903– 11. 10.4049/jimmunol.1201940 23152562 · DOI

Cited by

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Authors
Lewis Marffy, A. L., & McCarthy, A. J.
Affiliations
Imperial College London (GB)
Corresponding author
McCarthy, Alex J.
ORCID
McCarthy, Alex J.
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2020-05-13
Volume
11
Pages
857-857
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2020.00857
PMC
PMC7237751
OpenAlex
W3025179027
Cited by
63
References
1
Citations by year
2026: 7 · 2025: 11 · 2024: 7 · 2023: 14 · 2022: 14 · 2021: 8 · 2020: 2
FWCI
0.93
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Spiral (Imperial College London) (submittedVersion, other-oa)
Funders
  • Imperial College London
  • Medical Research Council (MR/P028225/1)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
leukocyte immunoglobulin-like receptors, neutrophils, inhibitory receptors, activating receptors, immune evasion, infection, inflammation regulation, receptor ligands, innate immunity
MeSH terms
Humans, Immunity, Innate, Infections, Membrane Glycoproteins, Neutrophils, Receptors, Immunologic, Antigens, CD, Immunomodulation

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