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Role of B cells as antigen presenting cells
Open accessAbstract
B cells have been long studied for their role and function in the humoral immune system. Apart from generating antibodies and an antibody-mediated memory response against pathogens, B cells are also capable of generating cell-mediated immunity. It has been demonstrated by several groups that B cells can activate antigen-specific CD4 and CD8 T cells, and can have regulatory and cytotoxic effects. The function of B cells as professional antigen presenting cells (APCs) to activate T cells has been largely understudied. This, however, requires attention as several recent reports have demonstrated the importance of B cells within the tumor microenvironment, and B cells are increasingly being evaluated as cellular therapies. Antigen presentation through B cells can be through antigen-specific (B cell receptor (BCR) dependent) or antigen non-specific (BCR independent) mechanisms and can be modulated by a variety of intrinsic and external factors. This review will discuss the pathways and mechanisms by which B cells present antigens, and how B cells differ from other professional APCs.
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“In addition, B cells produce cytokines and contribute to T cell activation through antigen presentation which can shape the overall immune responses [41,42].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [42]
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“B cells are a crucial component of the adaptive immune system, responsible for producing antibodies, providing an important line of defense against infectious agents.”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [42]
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Metadata
- Authors
- Rastogi, I., Jeon, D., Moseman, J. E., Muralidhar, A., Potluri, H. K., & McNeel, D. G.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- McNeel, Douglas G.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2022-09-08
- Volume
- 13
- Pages
- 954936-954936
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC9493130
- OpenAlex
- W4296111817
- Cited by
- 352
- References
- 236
- Citations by year
- 2026: 98 · 2025: 126 · 2024: 99 · 2023: 28 · 2022: 1
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (R01 CA219154, T32 CA009135, P30 CA014520)
- Congressionally Directed Medical Research Programs (W81XWH-17-1-0247)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- B cells, antigen-presenting cells, antigen presentation, B cell receptor, T cell activation, CD4+ T cells, CD8+ T cells, tumor microenvironment, humoral immunity, cell-mediated immunity
- MeSH terms
- Antigen-Presenting Cells, B-Lymphocytes, Receptors, Antigen, B-Cell, Antigen Presentation, CD8-Positive T-Lymphocytes
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