Cited by 354T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Response and Inflammation

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Role of B cells as antigen presenting cells

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Rastogi, Ichwaku, Jeon, Donghwan, Moseman, Jena E., Muralidhar, Anusha, Potluri, Hemanth K., McNeel, Douglas G.·2022·Frontiers in Immunology

DOI 10.3389/fimmu.2022.954936PMC PMC9493130

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Abstract

B cells have been long studied for their role and function in the humoral immune system. Apart from generating antibodies and an antibody-mediated memory response against pathogens, B cells are also capable of generating cell-mediated immunity. It has been demonstrated by several groups that B cells can activate antigen-specific CD4 and CD8 T cells, and can have regulatory and cytotoxic effects. The function of B cells as professional antigen presenting cells (APCs) to activate T cells has been largely understudied. This, however, requires attention as several recent reports have demonstrated the importance of B cells within the tumor microenvironment, and B cells are increasingly being evaluated as cellular therapies. Antigen presentation through B cells can be through antigen-specific (B cell receptor (BCR) dependent) or antigen non-specific (BCR independent) mechanisms and can be modulated by a variety of intrinsic and external factors. This review will discuss the pathways and mechanisms by which B cells present antigens, and how B cells differ from other professional APCs.

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Authors: Rastogi, I., Jeon, D., Moseman, J. E., Muralidhar, A., Potluri, H. K., & McNeel, D. G.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: McNeel, Douglas G.
ORCID: Rastogi, Ichwaku
Moseman, Jena E.
Muralidhar, Anusha
Potluri, Hemanth K.
McNeel, Douglas G.
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2022-09-08
Volume: 13
Pages: 954936-954936
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2022.954936
PMC: PMC9493130
OpenAlex: W4296111817
Cited by: 352
References: 236
Citations by year: 2026: 98 · 2025: 126 · 2024: 99 · 2023: 28 · 2022: 1
FWCI: 6.70
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Immunology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health (R01 CA219154, T32 CA009135, P30 CA014520)
Congressionally Directed Medical Research Programs (W81XWH-17-1-0247)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: B cells, antigen-presenting cells, antigen presentation, B cell receptor, T cell activation, CD4+ T cells, CD8+ T cells, tumor microenvironment, humoral immunity, cell-mediated immunity
MeSH terms: Antigen-Presenting Cells, B-Lymphocytes, Receptors, Antigen, B-Cell, Antigen Presentation, CD8-Positive T-Lymphocytes

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Role of B cells as antigen presenting cells

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