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Recent advances in exosome-based immunotherapy applied to cancer

Xie, Jindong, Zheng, Zihan, Tuo, Ling, Deng, Xinpei, Tang, Hailin, Peng, Cheng, Zou, Yutian·2023·Frontiers in Immunology
DOI 10.3389/fimmu.2023.1296857PMC PMC10662326
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Abstract

Cancer stands as a prominent contributor to global mortality rates, necessitating immediate attention toward the exploration of its treatment options. Extracellular vesicles have been investigated as a potential cancer therapy in recent years. Among them, exosomes, as cell-derived nanovesicles with functions such as immunogenicity and molecular transfer, offer new possibilities for immunotherapy of cancer. However, multiple studies have shown that exosomes of different cellular origins have different therapeutic effects. The immunomodulatory effects of exosomes include but are not limited to inhibiting or promoting the onset of immune responses, regulating the function of molecular signaling pathways, and serving as carriers of antitumor drugs. Therefore, this mini-review attempts to summarize and evaluate the development of strategies for using exosomes to package exogenous cargos to promote immunotherapy in cancer.

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Figure 1 The immunostimulatory and inhibitory effects of exosomes. This schematic shows the basic structure of exosomes and the mechanisms and functions of exosomes released by a variety of cells in regulating the immune response of tumor-bearing hosts. MHC, major histocompatibility complex; ICAM, intercellular cell adhesion molecule; CTLs, cytotoxic T lymphocytes; Tregs, regulatory cells, TDEs, tumor cell–derived exosomes .
Figure 1 The immunostimulatory and inhibitory effects of exosomes. This schematic shows the basic structure of exosomes and the mechanisms and functions of exosomes released by a variety of cells in regulating the immune response of tumor-bearing hosts. MHC, major histocompatibility complex; ICAM, intercellular cell adhesion molecule; CTLs, cytotoxic T lymphocytes; Tregs, regulatory cells, TDEs, tumor cell–derived exosomes .CC BY · PubMed Central

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Metadata

Authors
Xie, J., Zheng, Z., Tuo, L., Deng, X., Tang, H., Peng, C., & Zou, Y.
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2023-11-07
Volume
14
ISSN
1664-3224
DOI
10.3389/fimmu.2023.1296857
PMC
PMC10662326
Cited by
40
References
4
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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