Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential
Open accessAbstract
Mesenchymal stem cells (MSCs) are multipotent stromal cells that can be obtained from various human tissues and organs. They can differentiate into a wide range of cell types, including osteoblasts, adipocytes and chondrocytes, thus exhibiting great potential in regenerative medicine. Numerous studies have indicated that MSCs play critical roles in cancer biology. The crosstalk between tumour cells and MSCs has been found to regulate many tumour behaviours, such as proliferation, metastasis and epithelial-mesenchymal transition (EMT). Multiple lines of evidence have demonstrated that MSCs can secrete exosomes that can modulate the tumour microenvironment and play important roles in tumour development. Notably, very recent works have shown that mesenchymal stem cell-derived exosomes (MSC-derived exosomes) are critically involved in cancer resistance to chemotherapy agents, targeted-therapy drugs, radiotherapy and immunotherapy. In this review, we systematically summarized the emerging roles and detailed molecular mechanisms of MSC-derived exosomes in mediating cancer therapy resistance, thus providing novel insights into the clinical applications of MSC-derived exosomes in cancer management.
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Cross-communication between MSCs and cancer cells plays a crucial role in tumor growth, metastasis, and epithelial-to-mesenchymal transition.
“The cross-communication between MSC and cancer cells plays a crucial role in the development of multiple aspects of cancer including tumor growth, metastasis, and epithelial-to-mesenchymal transition [16].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [16]
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- Authors
- Lin, Z., Wu, Y., Xu, Y., Li, G., Li, Z., & Liu, T.
- Affiliations
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Corresponding author
- Li, Zhihong
- Liu, Tang
- Venue
- Molecular Cancer
- Published
- 2022-09-13
- Volume
- 21
- Issue
- 1
- Pages
- 179-179
- ISSN
- 1476-4598 (ISSN-L)
- PMC
- PMC9468526
- OpenAlex
- W4295750964
- Cited by
- 297
- References
- 158
- Citations by year
- 2026: 50 · 2025: 115 · 2024: 81 · 2023: 48 · 2022: 2 · 2012: 1
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Molecular Cancer (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (82072441, 2022JJ10095, 81871783)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- mesenchymal stem cells, exosomes, cancer therapy resistance, tumor microenvironment, chemoresistance, targeted therapy resistance, radiotherapy resistance, immunotherapy resistance, epithelial-mesenchymal transition, metastasis, regenerative medicine
- MeSH terms
- Humans, Neoplasms, Adipocytes, Exosomes, Tumor Microenvironment, Mesenchymal Stem Cells
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