Cited by 297Extracellular vesicles in diseaseMesenchymal stem cell researchCancer Cells and Metastasis

Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential

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Lin, Zhengjun, Wu, Yanlin, Xu, Yiting, Li, Guoqing, Li, Zhihong, Liu, Tang·2022·Molecular Cancer

Abstract

Mesenchymal stem cells (MSCs) are multipotent stromal cells that can be obtained from various human tissues and organs. They can differentiate into a wide range of cell types, including osteoblasts, adipocytes and chondrocytes, thus exhibiting great potential in regenerative medicine. Numerous studies have indicated that MSCs play critical roles in cancer biology. The crosstalk between tumour cells and MSCs has been found to regulate many tumour behaviours, such as proliferation, metastasis and epithelial-mesenchymal transition (EMT). Multiple lines of evidence have demonstrated that MSCs can secrete exosomes that can modulate the tumour microenvironment and play important roles in tumour development. Notably, very recent works have shown that mesenchymal stem cell-derived exosomes (MSC-derived exosomes) are critically involved in cancer resistance to chemotherapy agents, targeted-therapy drugs, radiotherapy and immunotherapy. In this review, we systematically summarized the emerging roles and detailed molecular mechanisms of MSC-derived exosomes in mediating cancer therapy resistance, thus providing novel insights into the clinical applications of MSC-derived exosomes in cancer management.

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Authors
Lin, Z., Wu, Y., Xu, Y., Li, G., Li, Z., & Liu, T.
Affiliations
  • Central South University (CN)
  • Second Xiangya Hospital of Central South University (CN)
Corresponding author
  • Li, Zhihong
  • Liu, Tang
Venue
Molecular Cancer
Published
2022-09-13
Volume
21
Issue
1
Pages
179-179
ISSN
1476-4598 (ISSN-L)
OpenAlex
W4295750964
Cited by
297
References
158
Citations by year
2026: 50 · 2025: 115 · 2024: 81 · 2023: 48 · 2022: 2 · 2012: 1
FWCI
6.40
Type
journal article
Language
en
Open access
Locations
  • Molecular Cancer (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (82072441, 2022JJ10095, 81871783)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
mesenchymal stem cells, exosomes, cancer therapy resistance, tumor microenvironment, chemoresistance, targeted therapy resistance, radiotherapy resistance, immunotherapy resistance, epithelial-mesenchymal transition, metastasis, regenerative medicine
MeSH terms
Humans, Neoplasms, Adipocytes, Exosomes, Tumor Microenvironment, Mesenchymal Stem Cells

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