Application of hydrogels in cancer immunotherapy: a bibliometric analysis
Open accessAbstract
Background: Cancer immunotherapy has made significant progress in recent years, with numerous studies worldwide. Immunotherapy has had a transformative impact on oncology and autoimmune diseases. In the biomedical arena, hydrogels with good properties are widely used in cancer immunotherapy. Our study used bibliometrics to analyze the changing trends in using hydrogels for cancer immunotherapy. Methods: From 2013 to 2023, a systematic search was conducted in the Web of Science Core Collection database to identify reviews and articles discussing the applications of hydrogels in cancer immunotherapy. The software CiteSpace was used to visually perform the bibliometric analysis in terms of research trends, countries, institutions, authors, journals, and keywords. Individual authors' productivity was assessed with the Lotka's law. The most relevant publication sources were identified by Bradford's law. Results: A total of 422 English-language publications related to hydrogels in cancer immunotherapy were collected. The number of annual publications increased rapidly after 2021 and remained constant for the past two years. China published the most articles in this field. The institution with the maximum number of published articles was the Chinese Academy of Sciences in China. Chen. Q was the most prolific author, and Liu. Z was the second most published author. In terms of journal contributions, the journal "Biomaterials" had the highest number of publications (n = 30). Biomaterials, Advanced Functional Materials and Journal of Controlled Release were the most influential journals. Keyword analysis revealed that cancer immunotherapy, drug delivery, immunogenic cell death, tumor microenvironment, injectable hydrogels, and immune checkpoint blockade were the primary research hotspots. In recent 3 years, adoptive T-cell therapy, black phosphorus, cell capture, adaptive cell therapy, tumor microenvironment, photodynamic therapy, and sustained release were the research hotspots in this field. Our study summarizes the objective of hydrogels in cancer immunotherapy in recent years, providing a reference for potential researchers in related field. Conclusion: This bibliometric analysis shows the progress and trend of research on hydrogels in cancer immunotherapy. This study provides a significant avenue for future investigation into current concerns and trends in research within this field.
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The variation in annual publication volume reflects the level of academic attention devoted to a specific research field.
“The variation in annual publication volume reflects the level of academic attention devoted to a specific research field (Liu et al., 2024).”
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Research trends and hotspots of cognitive behavioral therapy for tinnitus: a bibliometric analysis
He, Y., Liu, J., Cheng, H., Ye, H., Li, C., Gao, Y., & Xu, X. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1536224 · Cited by 2 · see citing works
- Authors
- Liu, X., Zhou, Q., Yang, Y., & Chen, E.
- Affiliations
- Jiangsu College of Nursing (CN)
- Corresponding author
- Liu, Xiang
- Chen, Erhua
- ORCID
- Liu, Xiang
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2024-08-13
- Volume
- 15
- Pages
- 1433050-1433050
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC11347446
- OpenAlex
- W4401602686
- Cited by
- 7
- References
- 84
- Citations by year
- 2026: 1 · 2025: 6
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- hydrogels, cancer immunotherapy, injectable hydrogel, drug delivery, immunogenic cell death, tumor microenvironment, immune checkpoint blockade, adoptive T cell therapy, black phosphorus, cell capture, photodynamic therapy, sustained drug release
- MeSH terms
- Animals, Humans, Immunotherapy, Neoplasms, Bibliometrics, Hydrogels
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