Cited by 90Pancreatic function and diabetesDiabetes and associated disordersTissue Engineering and Regenerative Medicine

Immunotherapy via PD-L1–presenting biomaterials leads to long-term islet graft survival

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Coronel, María M., Martin, Karen E., Hunckler, Michael D., Barber, Graham, O’Neill, Eric B., Medina, Juan D., Opri, Enrico, McClain, Claire A. +8 more·2020·Science Advances

Abstract

Local biomaterial-mediated delivery of PD-L1 induces alloislet graft survival and function in a murine model of type 1 diabetes.

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Crossref · 10.1126/sciadv.aba5573

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  • PD-L1 or FasL proteins immobilized onto the surface of poly(ethylene glycol) microgels, mixed with allogeneic islets and co-transplanted into mice or non-human primates, in conjunction with a transient rapamycin treatment, greatly improved islet survival without the need for long-term immunosuppression or encapsulation.

    “To this end, PD-L1111 or FasL112,113 proteins were immobilized onto the surface of poly(ethylene glycol) microgels, which were then mixed together with allogeneic islets and co-transplanted into either mice111,112 or non-human primates113. In conjunction with a transient rapamycin treatment, these functionalized microgels greatly improved islet survival without the need for long-term immunosuppres”

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Authors
Coronel, M. M., Martin, K. E., Hunckler, M. D., Barber, G., O’Neill, E. B., Medina, J. D., Opri, E., McClain, C. A., Batra, L., Weaver, J. D., Lim, H. S., Qiu, P., Botchwey, E. A., Yolcu, E. S., Shirwan, H., & García, A. J.
Affiliations
  • Georgia Institute of Technology (US)
  • Emory University (US)
  • University of Louisville (US)
  • Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Corresponding author
Shirwan, Haval
Venue
Science Advances
Published
2020-08-28
Volume
6
Issue
35
Pages
eaba5573-eaba5573
ISSN
2375-2548 (ISSN-L)
OpenAlex
W3081709993
Cited by
89
References
51
Citations by year
2026: 12 · 2025: 12 · 2024: 12 · 2023: 18 · 2022: 20 · 2021: 14 · 2020: 1
FWCI
12.11
Type
journal article
Language
en
Open access
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • NIH Office of the Director (R21EB020107, R01AI121281, U01AI132817, S10OD016264)
  • JDRF (3-PDF-2019-743-A-N)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
PD-L1, immune checkpoint blockade, islet transplantation, pancreatic islets, allograft rejection, rapamycin, regulatory T cells, anergic T cells, biomaterials, local immunomodulation, diabetes mellitus
MeSH terms
Animals, Biocompatible Materials, Graft Survival, Immunologic Factors, Immunotherapy, Mice, Inbred C57BL, Islets of Langerhans Transplantation, Streptavidin, Mice, B7-H1 Antigen, Programmed Cell Death 1 Receptor

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