Immunotherapy via PD-L1–presenting biomaterials leads to long-term islet graft survival
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Local biomaterial-mediated delivery of PD-L1 induces alloislet graft survival and function in a murine model of type 1 diabetes.
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PD-L1 or FasL proteins immobilized onto the surface of poly(ethylene glycol) microgels, mixed with allogeneic islets and co-transplanted into mice or non-human primates, in conjunction with a transient rapamycin treatment, greatly improved islet survival without the need for long-term immunosuppression or encapsulation.
“To this end, PD-L1111 or FasL112,113 proteins were immobilized onto the surface of poly(ethylene glycol) microgels, which were then mixed together with allogeneic islets and co-transplanted into either mice111,112 or non-human primates113. In conjunction with a transient rapamycin treatment, these functionalized microgels greatly improved islet survival without the need for long-term immunosuppres”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [111]
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- Authors
- Coronel, M. M., Martin, K. E., Hunckler, M. D., Barber, G., O’Neill, E. B., Medina, J. D., Opri, E., McClain, C. A., Batra, L., Weaver, J. D., Lim, H. S., Qiu, P., Botchwey, E. A., Yolcu, E. S., Shirwan, H., & García, A. J.
- Affiliations
- Georgia Institute of Technology (US)
- Emory University (US)
- University of Louisville (US)
- Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
- Corresponding author
- Shirwan, Haval
- ORCID
- Venue
- Science Advances
- Published
- 2020-08-28
- Volume
- 6
- Issue
- 35
- Pages
- eaba5573-eaba5573
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC7455180
- OpenAlex
- W3081709993
- Cited by
- 89
- References
- 51
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 12 · 2023: 18 · 2022: 20 · 2021: 14 · 2020: 1
- FWCI
- 12.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- NIH Office of the Director (R21EB020107, R01AI121281, U01AI132817, S10OD016264)
- JDRF (3-PDF-2019-743-A-N)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- PD-L1, immune checkpoint blockade, islet transplantation, pancreatic islets, allograft rejection, rapamycin, regulatory T cells, anergic T cells, biomaterials, local immunomodulation, diabetes mellitus
- MeSH terms
- Animals, Biocompatible Materials, Graft Survival, Immunologic Factors, Immunotherapy, Mice, Inbred C57BL, Islets of Langerhans Transplantation, Streptavidin, Mice, B7-H1 Antigen, Programmed Cell Death 1 Receptor
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