High overlap in patients diagnosed with hypermobile Ehlers-Danlos syndrome or hypermobile spectrum disorders with fibromyalgia and 40 self-reported symptoms and comorbidities
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Background: Joint pain is a common symptom in patients with hypermobile Ehlers-Danlos Syndrome (hEDS), hypermobility spectrum disorders (HSD) and fibromyalgia. The goal of this study was to determine whether symptoms and comorbidities overlap in patients diagnosed with hEDS/HSD and/or fibromyalgia. Methods: We retrospectively examined self-reported data from an EDS Clinic intake questionnaire in patients diagnosed with hEDS/HSD, fibromyalgia, or both vs. controls with an emphasis on joint issues. Results: From 733 patients seen at the EDS Clinic, 56.5% (n = 414) were diagnosed with hEDS/HSD and fibromyalgia (Fibro), 23.8% (n = 167) hEDS/HSD, 13.3% (n = 98) fibromyalgia, or 7.4% (n = 54) none of these diagnoses. More patients were diagnosed with HSD (76.6%) than hEDS (23.4%). Patients were primarily White (95%) and female (90%) with a median age in their 30s (controls 36.7 [18.0, 70.0], fibromyalgia 39.7 [18.0, 75.0], hEDS/HSD 35.0 [18.0, 71.0], hEDS/HSD&Fibro 31.0 [18.0, 63.0]). There was high overlap in all 40 symptoms/comorbidities that we examined in patients diagnosed with fibromyalgia only or hEDS/HSD&Fibro, regardless of whether they had hEDS or HSD. Patients that only had hEDS/HSD without fibromyalgia had far fewer symptoms/comorbidities than patients with hEDS/HSD&Fibro. The top self-reported issues in patients that only had fibromyalgia were joint pain, hand pain when writing or typing, brain fog, joint pain keeping from daily activities, allergy/atopy and headache. Five issues that significantly and uniquely characterized patients diagnosed with hEDS/HSD&Fibro were subluxations (dislocations in hEDS patients), joint issues like sprains, the need to stop sports due to injuries, poor wound healing, and migraine. Conclusion: The majority of patients seen at the EDS Clinic had a diagnosis of hEDS/HSD plus fibromyalgia that was associated with more severe disease. Our findings indicate that fibromyalgia should be routinely assessed in patients with hEDS/HSD and vis-a-versa to improve patient care.
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Out of six studies conducted in samples with HSD and/or EDS, four explored an association between these conditions and ASD.
“Out of six studies conducted in samples with HSD and/or EDS, four explored an association between these conditions and ASD (Cederlöf et al., 2016;Fairweather et al., 2023;Kelly, 2023;Kindgren et al., 2021).”
From Autism in the context of joint hypermobility, hypermobility spectrum disorders, and Ehlers–Danlos syndromes: A systematic review and prevalence meta-analyses (2025) · cites this paper as Fairweather et al., 2023
Fairweather et al. (2023) found no differences in rates of ASD in people with HSD/hEDS compared to three groups: patients with HSD/hEDS and fibromyalgia, patients with fibromyalgia only, and people without HSD/hEDS or fibromyalgia.
“The study by Fairweather et al. (2023) found no differences in rates of ASD in people with HSD/hEDS compared to three groups: patients with HSD/hEDS and fibromyalgia, patients with fibromyalgia only and people without HSD/hEDS or fibromyalgia.”
From Autism in the context of joint hypermobility, hypermobility spectrum disorders, and Ehlers–Danlos syndromes: A systematic review and prevalence meta-analyses (2025) · cites this paper as Fairweather et al., 2023
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Self-citationHypermobile Ehlers-Danlos Syndrome and widespread pain: Beyond structural laxity
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Inducible Laryngeal Obstruction in Hypermobile Patients
Menton, S. M., Fairweather, D., Wilson, F. C., Zangerle, D. J., Murphy, E. F., Darakjian, A. A., Thompson, C. C., Gajarawala, S. N., Knight, D. R. T., Bruno, K. A., et al. (2026) · The Laryngoscope · doi:10.1002/lary.70980
Self-citation
- Authors
- Fairweather, D., Bruno, K. A., Darakjian, A. A., Bruce, B. K., Gehin, J. M., Kotha, A., Jain, A., Peng, Z., Hodge, D. O., Rozen, T. D., Munipalli, B., Rivera, F. A., Malavet, P. A., & Knight, D. R. T.
- Affiliations
- Mayo Clinic (US)
- Mayo Clinic in Florida (US)
- Corresponding author
- Knight, Dacre R. T.
- ORCID
- Venue
- Frontiers in Medicine
- Publisher
- Frontiers Media SA
- Published
- 2023-04-25
- Volume
- 10
- Pages
- 1096180-1096180
- ISSN
- 2296-858X (ISSN-L)
- PMC
- PMC10166812
- OpenAlex
- W4366990018
- Semantic Scholar
- 444244d11c2157d667ae8705056bdca20e37b965
- Cited by
- 37
- References
- 49
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 14 · 2023: 3
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Mayo Clinic (RACER Award, STARDOM Award, Division of General Internal Medicine, Ralph E. Pounds and Kathy Olesker Pounds Fund in Research Related to Chronic Pain, Ralph E. Pounds and Kathy Olesker Pounds Fund in Research Related to Headache)
- American Heart Association (20TPA35490415)
- National Institutes of Health (R01 HL164520, R21 AI154927, R21 AI152318, R21 AI145356, R21 AI163302)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Keywords
- hypermobile Ehlers-Danlos syndrome, hypermobility spectrum disorders, fibromyalgia, symptom overlap, comorbidities, joint pain, subluxation, dislocations, migraine, delayed wound healing, hand pain, brain fog, atopy, headache, sports injuries
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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