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Cited by 19Acne and Rosacea Treatments and EffectsProbiotics and Fermented FoodsOral microbiology and periodontitis research

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Lactobacillus plantarum MH-301 as an effective adjuvant to isotretinoin in the treatment of acne vulgaris: a randomized and open-label trail

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Liang, Lili, Qi, Xinyue, Jiang, Xiaoke, Chen, Tingtao, Dong, Lina·2024·Frontiers in Medicine
DOI 10.3389/fmed.2023.1340068PMC PMC10803606
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Abstract

Introduction: Acne vulgaris is a common chronic inflammatory skin disease originating in the sebaceous gland units of the skin follicles. Isotretinoin is presently the primary choice for the treatment of acne vulgaris. However, it could induce several adverse reactions like diarrhea, cheilitis, headache, elevated triglyceride levels and risk of inflammatory bowel disease and depression. Hence, it is imperative to seek an alternative therapy. Methods: One hundred five patients were randomly divided into 3 groups, and received a baseline treatment of oral doxycycline for the initial 4 weeks. Group I received isotretinoin oral for 12 weeks; Group P received oral Lactobacillus plantarum MH-301 treatment for 12 weeks; Group IP received combined treatment with oral probiotics and oral isotretinoin for 12 weeks. The number of skin lesions was recorded at 0, 4, 8, and 12 weeks during the treatment to compare the efficacy of each intervention, and skin and fecal samples were collected from patients at 12 weeks for high-throughput sequencing to explore the microbiota differences between various groups. Results: Our results revealed that the combination of L. plantarum MH-301 with isotretinoin significantly reduced the number of skin lesions in patients compared to using L. plantarum MH-301 and isotretinoin alone (p < 0.001). Additionally, skin microbiome High-throughput analysis indicated the restorative effects of L. plantarum MH-301 on skin microbial diversity while also observing a reduction in the main microbiota of skin lesions, Propionibacterium and Corynebacterium. Meanwhile, gut microbiome High-throughput analysis showed that it could regulate disorders of the intestinal microbiota and increased the abundance of probiotics such as Lactobacillus, Bifidobacterium, Coprococcus and Bacteroides genera. Conclusion: In conclusion, L. plantarum MH-301 could be used in combination with isotretinoin for optimal results in the treatment of acne vulgaris. The research conducted provides theoretical and data support for the adjuvant effect of L. plantarum in the treatment of acne vulgaris. Clinical Trial Registration: [ClinicalTrials.gov], identifier (ChiCTR2200063499).

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Metadata

Authors
Liang, L., Qi, X., Jiang, X., Chen, T., & Dong, L.
Affiliations
  • Shanxi Medical University (CN)
  • Nanchang University (CN)
Corresponding author
  • Chen, Tingtao
  • Dong, Lina
ORCID
Venue
Frontiers in Medicine
Publisher
Frontiers Media SA
Published
2024-01-09
Volume
10
Pages
1340068-1340068
ISSN
2296-858X (ISSN-L)
DOI
10.3389/fmed.2023.1340068
PMC
PMC10803606
OpenAlex
W4390734692
Cited by
19
References
38
Citations by year
2026: 10 · 2025: 8 · 2024: 1
FWCI
6.97
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords
acne, isotretinoin, probiotics, adjuvant therapy, doxycycline, skin microbiome, gut microbiota, Propionibacterium, Corynebacterium, Lactobacillus, Bifidobacterium, Bacteroides, Coprococcus

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