The gut microbiome as a major regulator of the gut-skin axis

Salem, Iman; Ramser, Amy; Isham, Nancy; Ghannoum, Mahmoud A.

doi:10.3389/fmicb.2018.01459

Cited by 707Gut microbiota and healthDermatology and Skin DiseasesOral microbiology and periodontitis research

The gut microbiome as a major regulator of the gut-skin axis

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Salem, Iman, Ramser, Amy, Isham, Nancy, Ghannoum, Mahmoud A.·2018·Frontiers in Microbiology

DOI 10.3389/fmicb.2018.01459PMC PMC6048199

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Abstract

The adult intestine hosts a myriad of diverse bacterial species that reside mostly in the lower gut maintaining a symbiosis with the human habitat. In the current review, we describe the neoteric advancement in our comprehension of how the gut microbiota communicates with the skin as one of the main regulators in the gut-skin axis. We attempted to explore how this potential link affects skin differentiation and keratinization, its influence on modulating the cutaneous immune response in various diseases, and finally how to take advantage of this communication in the control of different skin conditions.

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The intestinal microbiome is closely related to common skin diseases, such as acne, psoriasis, and atopic dermatitis (AD).
“the intestinal microbiome is closely related to common skin diseases, such as acne, psoriasis, and atopic dermatitis (AD) [94].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [94]
After ingestion of probiotic tablets of Lactobacillus bulgaricus and Lactobacillus acidophilus by multiple acne patients, the majority of the acne patients' conditions improved.
“after ingestion of probiotic tablets of Lactobacillus bulgaricus and Lactobacillus acidophilus by multiple acne patients who participated in the experiment, it was found that the majority of the acne patients’ conditions improved [94].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [94]
Probiotics can play a role in preventing and treating AD by enhancing immunity.
“probiotics can play a role in preventing and treating AD by enhancing immunity [94].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [94]
Supplying probiotic milk to women and infants before and after delivery can effectively reduce the incidence rate of AD.
“the incidence rate of AD can be effectively reduced by supplying probiotic milk to women and infants before and after delivery [94].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [94]

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1 retracted

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Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity
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Gut microbiota dysbiosis in a cohort of patients with psoriasis
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The exposome in atopic dermatitis
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Acne, Microbiome, and Probiotics: The Gut–Skin Axis
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Microbiome and Probiotics in Acne Vulgaris—A Narrative Review
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The gut microbiota profile in psoriasis: a Brazilian case-control study
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Authors: Salem, I., Ramser, A., Isham, N., & Ghannoum, M. A.
Affiliations: Case Western Reserve University (US)
University Hospitals of Cleveland (US)
Corresponding author: Ghannoum, Mahmoud A.
ORCID: Ghannoum, Mahmoud A.
Venue: Frontiers in Microbiology
Publisher: Frontiers Media SA
Published: 2018-07-10
Volume: 9
Pages: 1459-1459
ISSN: 1664-302X (ISSN-L)
DOI: 10.3389/fmicb.2018.01459
PMC: PMC6048199
OpenAlex: W2808249516
Cited by: 707
References: 166
Citations by year: 2026: 98 · 2025: 115 · 2024: 100 · 2023: 76 · 2022: 120 · 2021: 95 · 2020: 59 · 2019: 39 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 1
FWCI: 4.78
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Microbiology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Case Western Reserve University
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK067629)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: gut microbiota, gut-skin axis, skin microbiome, skin differentiation, keratinization, skin immune response, skin diseases, host-microbe communication

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The gut microbiome as a major regulator of the gut-skin axis

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