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Cited by 28Acne and Rosacea Treatments and EffectsProbiotics and Fermented FoodsDermatology and Skin Diseases

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Topical Administration of Lactiplantibacillus plantarum (SkinDuoTM) Serum Improves Anti-Acne Properties

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Podrini, Christine, Schramm, Laetitia, Marianantoni, Giulia, Apolinarska, Jagienka, McGuckin, Colin, Forraz, Nico, Milet, Clément, Desroches, Anne-Laure, Payen, Pauline, D’Aguanno, Maria, Biazzo, Manuele·2023·Microorganisms
DOI 10.3390/microorganisms11020417PMC PMC9967017
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Abstract

The tailoring of the skin microbiome is challenging and is a research hotspot in the pathogenesis of immune-mediated inflammatory skin diseases such as acne. Commonly encountered preservatives used as functional ingredients have an impact on the skin microbiota and are known to inhibit the survival of skin commensal bacteria. The selected species is Lactiplantibacillus plantarum, formulated with natural enhancers for topical use (SkinDuoTM). Ex vivo human skin models were used as a test system to assess the strain viability which was then validated on healthy volunteers. SkinDuoTM showed increased viability over time for in vitro skin models and a stable viability of over 50% on healthy skin. The strain was tested on human primary sebocytes obtained from sebaceous gland rich areas of facial skin and inoculated with the most abundant bacteria from the skin microbiota. Results on human ex vivo sebaceous gland models with the virulent phylotype of Cutibacterium acnes and Staphylococcus epidermidis present a significant reduction in viability, lipid production, and anti-inflammatory markers. We have developed an innovative anti-acne serum with L. plantarum that mimics the over-production of lipids, anti-inflammatory properties, and improves acne-disease skin models. Based on these results, we suggest that SkinDuoTM may be introduced as an acne-mitigating agent.

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Metadata

Authors
Podrini, C., Schramm, L., Marianantoni, G., Apolinarska, J., McGuckin, C., Forraz, N., Milet, C., Desroches, A.-L., Payen, P., D’Aguanno, M., & Biazzo, M.
Affiliations
  • The BioArte Ltd., Malta Life Science Park (LS2.1.10, LS2.1.12, LS2.1.15), Triq San Giljan, SGN 3000 San Gwann, Malta
  • Cell Therapy Research Institute, CTIBIOTECH, Bat A16, 5 Avenue Lionel Terray, Meyzieu, 69330 Lyon, France
Corresponding author
  • Podrini, Christine
  • Biazzo, Manuele
ORCID
Venue
Microorganisms
Publisher
MDPI AG
Published
2023-02-07
Volume
11
Issue
2
Pages
417
ISSN
2076-2607 (ISSN-L)
DOI
10.3390/microorganisms11020417
PMC
PMC9967017
OpenAlex
W4319439776
Cited by
28
References
38
Citations by year
2026: 8 · 2025: 9 · 2024: 7 · 2023: 4
FWCI
7.16
Type
journal article
Language
en
Open access
Licence
Locations
  • Microorganisms (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
Lactobacillus plantarum, topical probiotics, acne, sebocytes, sebaceous glands, Propionibacterium acnes, Staphylococcus epidermidis, skin microbiome, strain viability, lipid production, anti-inflammatory activity, ex vivo skin model

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