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Cited by 473

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Extraintestinal Pathogenic Escherichia coli: A Combination of Virulence with Antibiotic Resistance

Open access
Pitout, Johann D. D.·2012·Frontiers in Microbiology

Abstract

Escherichia coli represents an incredible versatile and diverse enterobacterial species and can be subdivided into the following; (i) intestinal non-pathogenic, commensal isolates. (ii) Intestinal pathogenic isolates and (iii) extraintestinal pathogenic E. coli or ExPEC isolates. The presence to several putative virulence genes has been positively linked with the pathogenicity of ExPEC. E. coli remains one of the most frequent causes of nosocomial and community-acquired bacterial infections including urinary tract infections, enteric infections, and systemic infections in humans. ExPEC has emerged in 2000s as an important player in the resistance to antibiotics including the cephalosporins and fluoroquinolones. Most importantly among ExPEC is the increasing recognition of isolates producing "newer β-lactamases" that consists of plasmid-mediated AmpC β-lactamases (e.g., CMY), extended-spectrum β-lactamases (e.g., CTX-M), and carbapenemases (e.g., NDM). This review will highlight aspects of virulence associated with ExPEC, provide a brief overview of plasmid-mediated resistance to β-lactams including the characteristics of the successful international sequence types such as ST38, ST131, ST405, and ST648 among ExPEC.

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Metadata

Authors
Pitout, J. D. D.
Venue
Frontiers in Microbiology
Published
2012
Volume
3
Pages
9-9
ISSN
1664-302X (ISSN-L)
OpenAlex
W2112874950
Cited by
473
References
54
FWCI
17.59
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Extraintestinal Pathogenic Escherichia coli: A Combination of Virulence with Antibiotic Resistance. https://app.cochat.ai/papers/10.3389/fmicb.2012.00009
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Pitout, J. D. D. (2012). Extraintestinal Pathogenic Escherichia coli: A Combination of Virulence with Antibiotic Resistance. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2012.00009

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