The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
The role of metabolism in bacterial persistence
Open accessAbstract
Bacterial persisters are phenotypic variants with extraordinary tolerances toward antibiotics. Persister survival has been attributed to inhibition of essential cell functions during antibiotic stress, followed by reversal of the process and resumption of growth upon removal of the antibiotic. Metabolism plays a critical role in this process, since it participates in the entry, maintenance, and exit from the persister phenotype. Here, we review the experimental evidence that demonstrates the importance of metabolism to persistence, highlight the successes and potential of targeting metabolism in the search for anti-persister therapies, and discuss the current methods and challenges to understand persister physiology.
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Citations
Cites
1 retracted
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Bacterial Persistence as a Phenotypic Switch
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Self-citationActive Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria
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Cited by
Biofilms: an emergent form of bacterial life
Flemming, H.-C., Wingender, J., Szewzyk, U., Steinberg, P., Rice, S. A., & Kjelleberg, S. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.94 · Cited by 5,979
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence
Moradali, M. F., Ghods, S., & Rehm, B. H. A. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00039 · Cited by 1,537
Persistent bacterial infections and persister cells
Fisher, R. A., Gollan, B., & Helaine, S. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.42 · Cited by 1,243
Antibiotic resistance and persistence—implications for human health and treatment perspectives
Huemer, M., Mairpady Shambat, S., Brugger, S. D., & Zinkernagel, A. S. (2020) · The EMBO Reports · doi:10.15252/embr.202051034 · Cited by 850
Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms
Yan, J., & Bassler, B. L. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.06.002 · Cited by 747
Metadata
- Authors
- Amato, S. M., Fazen, C. H., Henry, T. C., Mok, W. W. K., Orman, M. A., Sandvik, E. L., Volzing, K. G., & Brynildsen, M. P.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2014
- Volume
- 5
- Pages
- 70-70
- ISSN
- 1664-302X (ISSN-L)
- OpenAlex
- W1982958351
- Cited by
- 258
- References
- 66
- FWCI
- 13.67
- Type
- journal article
- Language
- en
- Open access
- gold
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- Amato, S. M., Fazen, C. H., Henry, T. C., Mok, W. W. K., Orman, M. A., Sandvik, E. L., Volzing, K. G., & Brynildsen, M. P. (2014). The role of metabolism in bacterial persistence. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2014.00070
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
