The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
MALDI-TOF mass spectrometry: an emerging technology for microbial identification and diagnosis
Open accessAbstract
Currently microorganisms are best identified using 16S rRNA and 18S rRNA gene sequencing. However, in recent years matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has emerged as a potential tool for microbial identification and diagnosis. During the MALDI-TOF MS process, microbes are identified using either intact cells or cell extracts. The process is rapid, sensitive, and economical in terms of both labor and costs involved. The technology has been readily imbibed by microbiologists who have reported usage of MALDI-TOF MS for a number of purposes like, microbial identification and strain typing, epidemiological studies, detection of biological warfare agents, detection of water- and food-borne pathogens, detection of antibiotic resistance and detection of blood and urinary tract pathogens etc. The limitation of the technology is that identification of new isolates is possible only if the spectral database contains peptide mass fingerprints of the type strains of specific genera/species/subspecies/strains. This review provides an overview of the status and recent applications of mass spectrometry for microbial identification. It also explores the usefulness of this exciting new technology for diagnosis of diseases caused by bacteria, viruses, and fungi.
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Cites
Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya.
Woese, C. R., Kandler, O., & Wheelis, M. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4576 · Cited by 6,128
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“The MALDI Biotyper consisted of a basic MALDI-TOF platform, operating and analysis softwares, an onsite database and a simple method for extraction/preparation of sample (Seng et al., 2009).”
BackgroundMethodProkaryotic Diversity--Magnitude, Dynamics, and Controlling Factors
Torsvik, V., Øvreås, L., & Thingstad, T. F. (2002) · Science · doi:10.1126/science.1071698 · Cited by 1,196
Cited by
Antibiotic Resistance: One Health One World Outlook
Aslam, B., Khurshid, M., Arshad, M. I., Muzammil, S., Rasool, M., Yasmeen, N., Shah, T., Chaudhry, T. H., Rasool, M. H., Shahid, A., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.771510 · Cited by 609
Methods for the detection and identification of pathogenic bacteria: past, present, and future
Váradi, L., Luo, J. L., Hibbs, D. E., Perry, J. D., Anderson, R. J., Orenga, S., & Groundwater, P. W. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00693k · Cited by 561
A review of modern methods for the detection of foodborne pathogens
Aladhadh, M. (2023) · Microorganisms · doi:10.3390/microorganisms11051111 · Cited by 233
Abdel-Moneim, A.-M. E., El-Saadony, M. T., Shehata, A. M., Saad, A. M., Aldhumri, S. A., Ouda, S. M., & Mesalam, N. M. (2022) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.09.046 · Cited by 229
Can MALDI-TOF Mass Spectrometry Reasonably Type Bacteria?
Sauget, M., Valot, B., Bertrand, X., & Hocquet, D. (2017) · Trends in Microbiology · doi:10.1016/j.tim.2016.12.006 · Cited by 214
Metadata
- Authors
- Singhal, N., Kumar, M., Kanaujia, P. K., & Virdi, J. S.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2015-08-05
- Volume
- 6
- Pages
- 791-791
- ISSN
- 1664-302X (ISSN-L)
- OpenAlex
- W1550213267
- Cited by
- 1,605
- References
- 3
- FWCI
- 54.46
- Type
- journal article
- Language
- en
- Open access
- gold
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