Update on infections caused by Stenotrophomonas maltophilia with particular attention to resistance mechanisms and therapeutic options
Open accessAbstract
Stenotrophomonas maltophilia is a Gram-negative, biofilm-forming bacterium. Although generally regarded as an organism of low virulence, S. maltophilia is an emerging multi-drug resistant opportunistic pathogen in hospital and community settings, especially among immunocompromised hosts. Risk factors associated with S. maltophilia infection include underlying malignancy, cystic fibrosis, corticosteroid or immunosuppressant therapy, the presence of an indwelling central venous catheter and exposure to broad spectrum antibiotics. In this review, we provide a synthesis of information on current global trends in S. maltophilia pathogenicity as well as updated information on the molecular mechanisms contributing to its resistance to an array of antimicrobial agents. The prevalence of S. maltophilia infection in the general population increased from 0.8-1.4% during 1997-2003 to 1.3-1.68% during 2007-2012. The most important molecular mechanisms contributing to its resistance to antibiotics include β-lactamase production, the expression of Qnr genes, and the presence of class 1 integrons and efflux pumps. Trimethoprim/sulfamethoxazole (TMP/SMX) is the antimicrobial drug of choice. Although a few studies have reported increased resistance to TMP/SMX, the majority of studies worldwide show that S. maltophilia continues to be highly susceptible. Drugs with historically good susceptibility results include ceftazidime, ticarcillin-clavulanate, and fluoroquinolones; however, a number of studies show an alarming trend in resistance to those agents. Tetracyclines such as tigecycline, minocycline, and doxycycline are also effective agents and consistently display good activity against S. maltophilia in various geographic regions and across different time periods. Combination therapies, novel agents, and aerosolized forms of antimicrobial drugs are currently being tested for their ability to treat infections caused by this multi-drug resistant organism.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Stenotrophomonas is a recognized MDR human pathogen.
“Although common in the environment (Berg et al. 1999), Stenotrophomonas , is not recommended as a plant or soil amendment because it is also a recognized MDR human pathogen (Chang et al. 2015).”
From Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches (2021) · cites this paper as Chang et al. 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Falagas, M. E., Kasiakou, S. K., & Saravolatz, L. D. (2005) · Clinical Infectious Diseases · doi:10.1086/429323 · Cited by 1,745 · see citing works
Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen
Brooke, J. S. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00019-11 · Cited by 1,434 · see citing works
Molecular Properties of Bacterial Multidrug Transporters
Putman, M., van Veen, H. W., & Konings, W. N. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.4.672-693.2000 · Cited by 792 · see citing works
Jones, R. N. (2010) · Clinical Infectious Diseases · doi:10.1086/653053 · Cited by 716 · see citing works
Stenotrophomonas maltophilia: an emerging opportunist human pathogen
Looney, W. J., Narita, M., & Mühlemann, K. (2009) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(09)70083-0 · Cited by 553 · see citing works
Crossman, L. C., Gould, V. C., Dow, J. M., et al. (2008) · Genome biology · doi:10.1186/gb-2008-9-4-r74 · Cited by 546 · see citing works
Pfaller, M. A., Jones, R. N., Doern, G. V., Kugler, K. C., & The Sentry Participants Group (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.7.1762 · Cited by 539 · see citing works
Gales, A. C., Jones, R. N., Forward, K. R., Liñares, J., Sader, H. S., & Verhoef, J. (2001) · Clinical Infectious Diseases · doi:10.1086/320183 · Cited by 441 · see citing works
Gales, A. C., Reis, A. O., & Jones, R. N. (2001) · Journal of Clinical Microbiology · doi:10.1128/jcm.39.1.183-190.2001 · Cited by 381 · see citing works
Pfaller, M. A., Jones, R. N., & Beach, M. L. (1999) · Clinical Infectious Diseases · doi:10.1086/598640 · Cited by 312 · see citing works
Gales, A. C., Jones, R. N., & Sader, H. S. (2006) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2005.01351.x · Cited by 302 · see citing works
β-Lactam Resistance Response Triggered by Inactivation of a Nonessential Penicillin-Binding Protein
Moyá, B., Dötsch, A., Juan, C., et al. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000353 · Cited by 288 · see citing works
Morrissey, I., Hackel, M., Badal, R. E., Bouchillon, S. K., Hawser, S., & Biedenbach, D. J. (2013) · Pharmaceuticals · doi:10.3390/ph6111335 · Cited by 257 · see citing works
Valenza, G., Tappe, D., Turnwald, D., Frosch, M., König, C., Hebestreit, H. U., & Abele‐Horn, M. (2007) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2007.06.006 · Cited by 252 · see citing works
Sader, H. S., Farrell, D. J., Flamm, R. K., & Jones, R. N. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.01.007 · Cited by 249 · see citing works
Antimicrobial therapy for Stenotrophomonas maltophilia infections
Nicodemo, A. C., & Páez, J. I. G. (2007) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-007-0279-3 · Cited by 247 · see citing works
Safdar, A., & Rolston, K. V. I. (2007) · Clinical Infectious Diseases · doi:10.1086/522998 · Cited by 224 · see citing works
Toleman, M. A., Bennett, P. M., Bennett, D. M., et al. (2007) · Emerging infectious diseases · doi:10.3201/eid1304.061378 · Cited by 218 · see citing works
Alonso, A., & Martínez, J. L. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.11.3079-3086.2000 · Cited by 207 · see citing works
Lu, P., Liu, Y.-C., Toh, H. S., et al. (2012) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(12)70008-0 · Cited by 203 · see citing works
Vartivarian, S. E., Anaissie, E., Bodey, G. P., et al. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.3.624 · Cited by 200 · see citing works
Streit, J. M., Jones, R. N., Sader, H. S., et al. (2004) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2003.12.019 · Cited by 192 · see citing works
Antimicrobial susceptibility of uncommonly isolated non-enteric Gram-negative bacilli
Sader, H. S., & Jones, R. N. (2005) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2004.10.002 · Cited by 188 · see citing works
Stein, G. E., & Babinchak, T. (2013) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2012.12.004 · Cited by 183 · see citing works
Regulatory components in Citrobacter freundii ampC beta-lactamase induction.
Lindberg, F. P., Westman, L., & Normark, S. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.14.4620 · Cited by 182 · see citing works
Falagas, M. E., Valkimadi, P.-E., Huang, Y., Matthaiou, D. K., & Hsueh, P. (2008) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkn301 · Cited by 179 · see citing works
Self-citationFalagas, M. E., Kastoris, A. C., Vouloumanou, E. K., et al. (2009) · Future Microbiology · doi:10.2217/fmb.09.84 · Cited by 179 · see citing works
Bacteremia Due to Stenotrophomonas maltophilia in Patients with Hematologic Malignancies
Micozzi, A., Venditti, M., Monaco, M., Friedrich, A. W., Taglietti, F., Santilli, S., & Martino, P. (2000) · Clinical Infectious Diseases · doi:10.1086/314043 · Cited by 176 · see citing works
Zhanel, G. G., DeCorby, M. R., Adam, H. J., et al. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00469-10 · Cited by 167 · see citing works
Sader, H. S., Jones, R. N., Gales, A. C., et al. (2004) · The Brazilian Journal of Infectious Diseases · doi:10.1590/s1413-86702004000100004 · Cited by 159 · see citing works
Fimbriae and adherence of Stenotrophomonas maltophilia to epithelial cells and to abiotic surfaces
de Oliveira-Garcia, D., DallʼAgnol, M., Rosales, M., et al. (2003) · Cellular Microbiology · doi:10.1046/j.1462-5822.2003.00306.x · Cited by 158 · see citing works
Jones, R. N., Kugler, K. C., Pfaller, M. A., et al. (1999) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(98)00158-8 · Cited by 155 · see citing works
Zhanel, G. G., Adam, H. J., Baxter, M. R., et al. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkt022 · Cited by 149 · see citing works
Brooke, J. S. (2013) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2014.864553 · Cited by 148 · see citing works
SmeC, an Outer Membrane Multidrug Efflux Protein of Stenotrophomonas maltophilia
Li, X.-Z., Zhang, L., & Poole, K. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.2.333-343.2002 · Cited by 147 · see citing works
Farrell, D. J., Sader, H. S., Flamm, R. K., & Jones, R. N. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.01.032 · Cited by 146 · see citing works
Hu, L., Chang, X. L., Ye, Y., et al. (2011) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2010.10.025 · Cited by 146 · see citing works
Páez, J. I. G., & Costa, S. F. (2008) · Journal of Hospital Infection · doi:10.1016/j.jhin.2008.05.020 · Cited by 144 · see citing works
Doern, G. V., Jones, R. N., Pfaller, M. A., Kugler, K. C., & Beach, M. L. (1999) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(98)00162-x · Cited by 140 · see citing works
Hoban, D. J., Biedenbach, D. J., Mutnick, A. H., & Jones, R. N. (2003) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(02)00540-0 · Cited by 136 · see citing works
Samonis, G., Karageorgopoulos, D. E., Maraki, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037375 · Cited by 136 · see citing works
Community-acquired Stenotrophomonas maltophilia infections: a systematic review
Falagas, M. E., Kastoris, A. C., Vouloumanou, E. K., et al. (2009) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-009-0709-5 · Cited by 134 · see citing works
Fluit, A. C., Schmitz, F., & Verhoef, J. (2001) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s100960100455 · Cited by 132 · see citing works
Lai, C.-H., Chi, C.-Y., Chen, H., et al. (2004) · PubMed · Cited by 129 · see citing works
Jones, R. N., Sader, H. S., & Beach, M. L. (2003) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(03)00245-0 · Cited by 129 · see citing works
Wang, Y. L., Scipione, M. R., Dubrovskaya, Y., et al. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01324-13 · Cited by 127 · see citing works
Lodge, J., Minchin, S., Piddock, L. J. V., et al. (1990) · Biochemical Journal · doi:10.1042/bj2720627 · Cited by 126 · see citing works
Pompilio, A., Crocetta, V., Confalone, P., et al. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-102 · Cited by 123 · see citing works
Hombach, M., Bloemberg, G. V., & Böttger, E. C. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr524 · Cited by 123 · see citing works
Entenza, J. M., & Moreillon, P. (2009) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2008.11.006 · Cited by 122 · see citing works
Sader, H. S., Jones, R. N., Gales, A. C., et al. (1998) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(98)00124-2 · Cited by 122 · see citing works
Sánchez, M. B., Hernández, A., Rodríguez-Martínez, J. M., et al. (2008) · BMC Microbiology · doi:10.1186/1471-2180-8-148 · Cited by 116 · see citing works
Walkty, A. J., Adam, H. J., Baxter, M. R., et al. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02744-13 · Cited by 115 · see citing works
Sader, H. S., Jones, R. N., Dowzicky, M. J., & Fritsche, T. R. (2005) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2005.05.002 · Cited by 114 · see citing works
Sader, H. S., Jones, R. N., Stilwell, M. G., et al. (2005) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2005.05.005 · Cited by 114 · see citing works
Fluit, A. C., Verhoef, J., Schmitz, F., & Participants, T. E. S. (2001) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s100960100564 · Cited by 113 · see citing works
Okazaki, A., & Avison, M. B. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01485-07 · Cited by 112 · see citing works
Farrell, D. J., Sader, H. S., & Jones, R. N. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01774-09 · Cited by 111 · see citing works
Saiman, L. M., Chen, Y., Gabriel, P. S., et al. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.4.1105-1107.2002 · Cited by 110 · see citing works
Self-citationStenotrophomonas maltophilia drug resistance
Sánchez, M. B., Hernandez, A., & Martínez, J. L. (2009) · Future Microbiology · doi:10.2217/fmb.09.45 · Cited by 109 · see citing works
Fedler, K. A., Biedenbach, D. J., & Jones, R. N. (2006) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2006.07.003 · Cited by 106 · see citing works
Bouchillon, S. K., Badal, R. E., Hoban, D. J., et al. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.03.022 · Cited by 105 · see citing works
Magret, M., Lisboa, T., Martin-Loeches, I., Máñez, R., Nauwynck, M., Wrigge, H., Cardellino, S., Díaz, E., Koulenti, D., Rello, J., et al. (2011) · Critical Care · doi:10.1186/cc10036 · Cited by 105 · see citing works
Cho, S. Y., Kang, C., Kim, J., et al. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01682-13 · Cited by 104 · see citing works
Lin, Y.-T., Huang, Y.-W., Chen, S.-J., et al. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00372-15 · Cited by 104 · see citing works
MacLeod, D. L., Barker, L. M., Sutherland, J. L., et al. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp282 · Cited by 101 · see citing works
Gabriel, P. S., Zhou, J. J., Tabibi, S., et al. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.1.168-171.2004 · Cited by 100 · see citing works
Nicodemo, A. C. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh128 · Cited by 99 · see citing works
O’Riordan, W. D., Mehra, P., Manos, P., et al. (2014) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2014.10.009 · Cited by 98 · see citing works
Barbolla, R. E., Catalano, M., Orman, B. E., Famiglietti, A. M. R., Vay, C. A., Smayevsky, J., Centrón, D., & Piñeiro, S. A. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.2.666-669.2004 · Cited by 98 · see citing works
Falagas, M. E., Vardakas, K. Z., Tsiveriotis, K., et al. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.01.006 · Cited by 97 · see citing works
Clinical Epidemiology of Stenotrophomonas maltophilia Colonization and Infection
TORO, M. D. D., Rodríguez‐Baño, J., Herrero, M., et al. (2002) · Medicine · doi:10.1097/00005792-200205000-00006 · Cited by 96 · see citing works
Xanthomonas maltophilia Bacteremia in Immunocompromised Hematological Patients
Victor, M., Arpi, M., Bruun, B., et al. (1994) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365549409011780 · Cited by 93 · see citing works
Xanthomonas maltophilia bacteremia: an analysis of 32 cases.
Jang, T. N., Wang, F. D., Wang, L. S., et al. (1992) · PubMed · Cited by 92 · see citing works
Chen, C.-H., Huang, C., Chung, T.-C., et al. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00317-11 · Cited by 90 · see citing works
Aph(3′)-IIc, an Aminoglycoside Resistance Determinant from Stenotrophomonas maltophilia
Okazaki, A., & Avison, M. B. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00795-06 · Cited by 90 · see citing works
García‐León, G., Hernández, A., Hernando‐Amado, S., et al. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.01058-14 · Cited by 88 · see citing works
Labarca, J. A., Leber, A. L., Kern, V., et al. (2000) · Clinical Infectious Diseases · doi:10.1086/313591 · Cited by 88 · see citing works
Castanheira, M., Mendes, R. E., & Jones, R. N. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu706 · Cited by 85 · see citing works
Lin, Y.-T., Huang, Y.-W., Liou, R.-S., Chang, Y.-C., & Yang, T. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku317 · Cited by 85 · see citing works
Self-citationLi, X.-Z. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg148 · Cited by 84 · see citing works
Mathai, D., Lewis, M. T., Kugler, K. C., et al. (2001) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(00)00234-0 · Cited by 83 · see citing works
Yang, T., Huang, Y.-W., Hu, R., et al. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01513-08 · Cited by 83 · see citing works
SmQnr Contributes to Intrinsic Resistance to Quinolones in Stenotrophomonas maltophilia
Sánchez, M. B., & Martínez, J. L. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00496-09 · Cited by 83 · see citing works
Antimicrobial Susceptibilities of Unique Stenotrophomonas maltophilia Clinical Strains
Valdezate, S., Vindel, A., Loza, E., et al. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.5.1581-1584.2001 · Cited by 81 · see citing works
Clinical features of Stenotrophomonas maltophilia pneumonia in immunocompromised patients
Fujita, J., Yamadori, I., Xu, G., et al. (1996) · Respiratory Medicine · doi:10.1016/s0954-6111(96)90242-5 · Cited by 81 · see citing works
Antimicrobial resistance among non-fermenting Gram-negative bacteria in Saudi Arabia
Memish, Z. A., Shibl, A. M., Kambal, A. M., et al. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dks091 · Cited by 78 · see citing works
Gales, A. C., Sader, H., & Jones, R. N. (2002) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(02)00499-6 · Cited by 77 · see citing works
Zhanel, G. G., Adam, H. J., Low, D. E., et al. (2011) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2010.10.025 · Cited by 75 · see citing works
Hu, R., Liao, S.-T., Huang, C., Huang, Y.-W., & Yang, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051053 · Cited by 72 · see citing works
Susceptibility of Pseudomonas maltophilia to antimicrobial agents, singly and in combination
Felegie, T. P., Yu, V. L., Rumans, L. W., et al. (1979) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.16.6.833 · Cited by 71 · see citing works
Sader, H. S., Flamm, R. K., & Jones, R. N. (2013) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2013.02.009 · Cited by 70 · see citing works
Vartivarian, S. E. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.156.4.433 · Cited by 70 · see citing works
Al‐Anazi, K. A., & Al-Jasser, A. M. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00232 · Cited by 69 · see citing works
Lai, C.-H., Wong, W. W., Chin, C., et al. (2006) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2006.01511.x · Cited by 68 · see citing works
Sánchez, M. B., & Martínez, J. L. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00714-15 · Cited by 68 · see citing works
Hotta, G., Matsumura, Y., Kato, K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112208 · Cited by 67 · see citing works
Interplay between intrinsic and acquired resistance to quinolones in S tenotrophomonas maltophilia
García‐León, G., Salgado, F., Oliveros, J. C., et al. (2014) · Environmental Microbiology · doi:10.1111/1462-2920.12408 · Cited by 66 · see citing works
King, P. A., Lomovskaya, O., Griffith, D. C., et al. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00248-09 · Cited by 66 · see citing works
Sm qnr , a New Chromosome-Carried Quinolone Resistance Gene in Stenotrophomonas maltophilia
Shimizu, K., Kikuchi, K., Sasaki, T., et al. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00026-08 · Cited by 65 · see citing works
Moskowitz, S. M., Garber, E., Chen, Y., Clock, S. A., Tabibi, S., Miller, A. K., Doctor, M., & Saiman, L. M. (2010) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkq131 · Cited by 65 · see citing works
Self-citationMeyer, E., Schwab, F., Gastmeier, P., et al. (2006) · Journal of Hospital Infection · doi:10.1016/j.jhin.2006.07.006 · Cited by 64 · see citing works
Livermore, D. M., Hope, R., Brick, G., et al. (2008) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkn352 · Cited by 63 · see citing works
In vitro activities of antimicrobial combinations against Stenotrophomonas (Xanthomonas) maltophilia
Poulos, C., Matsumura, S., Willey, B., et al. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.10.2220 · Cited by 63 · see citing works
Zhanel, G. G., DeCorby, M. R., Nichol, K. A., et al. (2008) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2008.04.012 · Cited by 62 · see citing works
Milne, K., & Gould, I. M. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00072-12 · Cited by 62 · see citing works
Stenotrophomonas (Xanthomonas) maltophilia Urinary Tract Infection
Vartivarian, S. E. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440040111012 · Cited by 62 · see citing works
Jones, R. N., Croco, M. A. T., Kugler, K. C., Pfaller, M. A., & Beach, M. L. (2000) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(00)00115-2 · Cited by 61 · see citing works
A multicenter surveillance of antimicrobial resistance on Stenotrophomonas maltophilia in Taiwan
Wu, H., Wang, J.-T., Shiau, Y., et al. (2011) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2011.09.028 · Cited by 61 · see citing works
Gould, V. C., Okazaki, A., & Avison, M. B. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01020-12 · Cited by 60 · see citing works
Hornsey, M., Longshaw, C. M., Phee, L. M., & Wareham, D. W. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05870-11 · Cited by 60 · see citing works
Chang, Y.-T., Lin, C., Lu, P., et al. (2012) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2012.08.014 · Cited by 59 · see citing works
Self-citationChung, H., Kim, K., Hong, S. S., et al. (2015) · Annals of Laboratory Medicine · doi:10.3343/alm.2015.35.2.246 · Cited by 58 · see citing works
Giamarellos‐Bourboulis, E. J., Karnesis, L., & Giamarellou, H. (2002) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(02)00443-1 · Cited by 58 · see citing works
Al-Hamad, A., Upton, M., & Burnie, J. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp271 · Cited by 57 · see citing works
Huang, Y.-W., Hu, R., Chu, F., Lin, H.-R., & Yang, T. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkt250 · Cited by 57 · see citing works
Huang, Y.-W., Liou, R.-S., Lin, Y.-T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111784 · Cited by 56 · see citing works
Gülmez, D., & Hasçelik, G. (2005) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2005.01257.x · Cited by 54 · see citing works
García‐León, G., Puig, C. R. D. A., de la Fuente, C. G., et al. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.01.007 · Cited by 53 · see citing works
Gülmez, D., Çakar, A., Şener, B., et al. (2010) · Journal of Infection and Chemotherapy · doi:10.1007/s10156-010-0068-2 · Cited by 53 · see citing works
Chung, H., Chong, Y., Kim, Y. R., et al. (2013) · Journal of Korean Medical Science · doi:10.3346/jkms.2013.28.1.62 · Cited by 53 · see citing works
Flores-Treviño, S., Gutiérrez-Ferman, J. L., Morfín‐Otero, R., Rodríguez-Noriega, E., Estrada‐Rivadeneyra, D., Rivas-Morales, C., Llaca-Díaz, J. M., Camacho-Ortíz, A., Mendoza-Olazarán, S., & Garza‐González, E. (2014) · Journal of Medical Microbiology · doi:10.1099/jmm.0.074385-0 · Cited by 52 · see citing works
Wu, K., Yau, Y. C. W., Matukas, L. M., et al. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02215-12 · Cited by 52 · see citing works
SmeOP-TolC Sm Efflux Pump Contributes to the Multidrug Resistance of Stenotrophomonas maltophilia
Lin, C., Huang, Y.-W., Hu, R., et al. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01974-13 · Cited by 51 · see citing works
Self-citationTan, R., Liu, J., Li, M., et al. (2013) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2012.11.006 · Cited by 49 · see citing works
Fihman, V., Monnier, A. L., Corvec, S., et al. (2012) · Journal of Infection · doi:10.1016/j.jinf.2012.01.001 · Cited by 49 · see citing works
New Treatments for Emerging Cystic Fibrosis Pathogens other than Pseudomonas
Waters, V. J. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799315939 · Cited by 49 · see citing works
Page, M. G. P., Dantier, C., Desarbre, E., Gaucher, B., Gebhardt, K., & Schmitt‐Hoffmann, A. H. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01370-10 · Cited by 49 · see citing works
Cantón, R., Valdezate, S., Vindel, A., et al. (2003) · Pediatric Pulmonology · doi:10.1002/ppul.10216 · Cited by 48 · see citing works
Sader, H. S., Farrell, D. J., Flamm, R. K., & Jones, R. N. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02684-13 · Cited by 47 · see citing works
Yang, Q., Wang, H., Chen, M., Ni, Y., Yu, Y., Hu, B., Sun, Z., Huang, W., Hu, Y., Ye, H., et al. (2010) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2010.09.001 · Cited by 46 · see citing works
Hernández, A., Maté, M. J., Sánchez-Díaz, P. C., Romero, A., Rojo, F., & Martínez, J. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809221200 · Cited by 46 · see citing works
CHOW, A. W. C., Wong, J., & Bartlett, K. H. (1988) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.32.5.782 · Cited by 46 · see citing works
Jones, R. N., Pfaller, M. A., Marshall, S. A., et al. (1997) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(97)81808-1 · Cited by 44 · see citing works
Liu, Y.-M., Chen, Y.-S., Toh, H. S., et al. (2012) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(12)70004-3 · Cited by 44 · see citing works
Self-citationValdezate, S., Vindel, A., Sáez-Nieto, J. A., et al. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki182 · Cited by 44 · see citing works
Chen, Y., Lu, P., Huang, C.-H., et al. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.06053-11 · Cited by 43 · see citing works
Self-citationTigecycline as a therapeutic option inStenotrophomonas maltophiliainfections
Tekce, Y. T., Erbay, A., Çabadak, H., et al. (2012) · Journal of Chemotherapy · doi:10.1179/1120009x12z.00000000022 · Cited by 42 · see citing works
Betts, J. W., Phee, L. M., Woodford, N., & Wareham, D. W. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-014-2101-3 · Cited by 42 · see citing works
In vitro activity of potential old and new drugs against multidrug-resistant gram-negatives
Rizek, C., Ferraz, J. R., van der Heijden, I. M., et al. (2014) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2014.10.009 · Cited by 40 · see citing works
Visalli, M. A., Jacobs, M. R., & Appelbaum, P. C. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.8.2002 · Cited by 40 · see citing works
Yu, V. L., Felegie, T. P., Vee, R. B., et al. (1980) · The Journal of Infectious Diseases · doi:10.1093/infdis/142.4.602 · Cited by 39 · see citing works
Nord, C., Wadström, T., & Wretlind, B. (1974) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.6.4.521 · Cited by 38 · see citing works
Wood, G. C., Underwood, E. L., Croce, M. A., et al. (2010) · Annals of Pharmacotherapy · doi:10.1345/aph.1p217 · Cited by 38 · see citing works
Wang, C.-H., Lin, J., Lin, H., et al. (2014) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2014.06.005 · Cited by 37 · see citing works
Stenotrophomonas MaltophiliaInfections
Dignani, M. C., Grazziutti, M., & Anaissie, E. J. (2003) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-2003-37920 · Cited by 36 · see citing works
Epidemiology of bacteremia caused by uncommon non-fermentative gram-negative bacteria
Rattanaumpawan, P., Ussavasodhi, P., Kiratisin, P., et al. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-167 · Cited by 36 · see citing works
Stenotrophomonas maltophilia: An Unusual Cause of Biliary Sepsis
Papadakis, K. A., Vartivarian, S. E., Vassilaki, M. E., et al. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/21.4.1032 · Cited by 35 · see citing works
Synergy with double and triple antibiotic combinations compared
Berenbaum, M. C., Yu, V. L., & Felegie, T. P. (1983) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/12.6.555 · Cited by 35 · see citing works
Huang, Y.-W., Lin, C., Hu, R., Lin, Y.-T., Chung, T., & Yang, T. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01283-09 · Cited by 35 · see citing works
Self-citationDelafloxacin for the treatment of respiratory and skin infections
Bassetti, M., Siega, P. D., Pecori, D., Scarparo, C., & Righi, E. (2015) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2015.1005205 · Cited by 35 · see citing works
Antimicrobial susceptibility and combination testing of invasiveStenotrophomonas maltophiliaisolates
Church, D. L., Lloyd, T., Peirano, G., et al. (2012) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365548.2012.732240 · Cited by 33 · see citing works
Gales, A. C., Sader, H. S., & Fritsche, T. R. (2008) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2007.10.017 · Cited by 33 · see citing works
Kim, T., Chong, Y. P., Park, S. Y., et al. (2014) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2013.08.011 · Cited by 32 · see citing works
Tada, T., Miyoshi‐Akiyama, T., Dahal, R. K., et al. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03354-14 · Cited by 32 · see citing works
Lee, Y.-L., Chen, Y.-S., Toh, H. S., et al. (2012) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(12)70007-9 · Cited by 31 · see citing works
Self-citationLin, C., Lin, H., Huang, Y.-W., et al. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr276 · Cited by 31 · see citing works
Self-citationFarrell, D. J., Turnidge, J. D., Bell, J. M., Sader, H. S., & Jones, R. N. (2010) · Journal of Infection · doi:10.1016/j.jinf.2010.03.024 · Cited by 31 · see citing works
Role of the pcm-tolCsm operon in the multidrug resistance of Stenotrophomonas maltophilia
Huang, Y.-W., Hu, R., & Yang, T. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkt148 · Cited by 30 · see citing works
Livermore, D. M., Mushtaq, S., Warner, M., et al. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkt455 · Cited by 28 · see citing works
Guembe, M., Cercenado, E., Alcalá, L., et al. (2008) · PubMed · Cited by 27 · see citing works
Pneumonia caused by Stenotrophomonas maltophilia with a mucoid phenotype
Irifune, K., ISHIDA, T., SHIMOGUCHI, K., et al. (1994) · Journal of Clinical Microbiology · doi:10.1128/jcm.32.11.2856-2857.1994 · Cited by 26 · see citing works
Ratjen, A., Yau, Y. C. W., Wettlaufer, J., et al. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.04123-14 · Cited by 25 · see citing works
Chen, X.-X., Lo, Y.-C., Su, L., & Chang, C.-L. (2014) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2014.03.006 · Cited by 24 · see citing works
Renteria, M., Biedenbach, D. J., Bouchillon, S. K., et al. (2014) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2014.01.017 · Cited by 24 · see citing works
Pien, C.-J., Kuo, H., Chang, S., et al. (2013) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2013.09.005 · Cited by 23 · see citing works
Rhee, J.-Y., Choi, J. Y., Choi, M., et al. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.053355-0 · Cited by 23 · see citing works
Jones, R. N., Croco, M. A. T., Pfaller, M. A., et al. (1999) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.1999.tb00432.x · Cited by 22 · see citing works
Talfan, A., Mounsey, O., Charman, M., et al. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01446-13 · Cited by 21 · see citing works
Fluit, A. C., Schmitz, F.-J., & Verhoef, J. (2001) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-001-8078-8 · Cited by 21 · see citing works
Arthur, C., Tang, X., Romero, J. R., et al. (2014) · Pediatric Cardiology · doi:10.1007/s00246-014-1041-0 · Cited by 20 · see citing works
The potential role of nemonoxacin for treatment of common infections
Huang, C., Lai, C.-C., Chen, Y., & Hsueh, P. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.978288 · Cited by 20 · see citing works
Self-citationFedler, K. A., Jones, R. N., Sader, H. S., et al. (2006) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2006.01.005 · Cited by 17 · see citing works
Susceptibility ofStenotrophomonas maltophiliaclinical strains in China to antimicrobial combinations
Hu, L., Gao, L., Ye, Y., et al. (2014) · Journal of Chemotherapy · doi:10.1179/1973947814y.0000000168 · Cited by 17 · see citing works
Khan, I. U., Mirza, I. A., Ikram, A., et al. (2014) · PubMed · Cited by 17 · see citing works
Meningitis due to Stenotrophomonas maltophilia after a Neurosurgical Procedure
Sood, S. (2013) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2013/5614.3248 · Cited by 16 · see citing works
S tenotrophomonas maltophilia: Rare cause of meningitis
Correia, C., Ferreira, S. T., & Nunes, P. (2014) · Pediatrics International · doi:10.1111/ped.12352 · Cited by 15 · see citing works
The Clinical Spectrum of Stenotrophomonas (Xanthomonas) Maltophilia Respiratory Infection
Vartivarian, S. E., Anaissie, E. J., Kiwan, E. N., et al. (2000) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-2000-9859 · Cited by 15 · see citing works
Personne, Y., Curtis, M. A., Wareham, D. W., et al. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku309 · Cited by 15 · see citing works
Ning, B., Zhang, C., Liu, T., et al. (2012) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2012.757 · Cited by 14 · see citing works
In vitro activity of colistin against Stenotrophomonas maltophilia
Rodríguez, C. H., Nastro, M., Calvo, J. L., et al. (2014) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2014.04.004 · Cited by 14 · see citing works
Nemonoxacin (TG-873870) for treatment of community-acquired pneumonia
Lai, C.-C., Lee, K., Lin, S., Chen, Y., Kuo, H., Hung, C., & Hsueh, P. (2014) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2014.894881 · Cited by 14 · see citing works
Self-citationJean, S., Lee, W., Bai, K., et al. (2013) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2013.07.002 · Cited by 13 · see citing works
Lee, M., Wang, H., Yang, C., et al. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-014-2060-8 · Cited by 12 · see citing works
Pérez, P. N., Ramirez, M. A., Fernández, J. A., et al. (2014) · Infectious Disease Reports · doi:10.4081/idr.2014.5147 · Cited by 12 · see citing works
Pseudomonas maltophilia infections in neutropenic patients and the use of imipenem
Kerr, K., Hawkey, P. M., Child, J. A., et al. (1990) · Postgraduate Medical Journal · doi:10.1136/pgmj.66.782.1090 · Cited by 10 · see citing works
High-dosage tigecycline for Stenotrophomonas maltophilia bacteremia
Wu, Y., & Zonghong, S. (2014) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20140364 · Cited by 7 · see citing works
Stenotrophomonas Infection in a Patient with Glucose-6-Phosphate Dehydrogenase Deficiency
Harthan, A. A., & Heger, M. L. (2013) · The Journal of Pediatric Pharmacology and Therapeutics · doi:10.5863/1551-6776-18.2.137 · Cited by 6 · see citing works
Lai, W.-A., Chen, S.-F., Tsai, N., et al. (2013) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2013.10.020 · Cited by 3 · see citing works
CABI (2019) · CABI Compendium · doi:10.1079/cabicompendium.56951 · Cited by 1 · see citing works
In vitro susceptibility of Stenotrophomonas maltophilia to various antimicrobial combinations.
斎藤, 美., 福澤, め., & Nix, D. E. (2002) · PubMed · doi:10.1016/s0732-8893(01)00281-4
Flagged first, then by citations
Cited by
Sorted by citations
Tamma, P. D., Aitken, S. L., Bonomo, R. A., Mathers, A. J., van Duin, D., & Clancy, C. J. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciad428 · Cited by 740 · see citing works
Wani, K. I., Choudhary, S., Zehra, A., Naeem, M., Weathers, P., & Aftab, T. (2021) · Planta · doi:10.1007/s00425-021-03676-3 · Cited by 74 · see citing works
- Authors
- Chang, Y.-T., Lin, C.-Y., Chen, Y.-H., & Hsueh, P.-R.
- Affiliations
- Kaohsiung Medical University (TW)
- National Yang Ming Chiao Tung University (TW)
- National Taiwan University (TW)
- Corresponding author
- Chen, Yen-Hsu
- Hsueh, Po-Ren
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2015-09-02
- Volume
- 6
- Pages
- 893-893
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC4557615
- OpenAlex
- W1921056904
- Cited by
- 419
- References
- 191
- Citations by year
- 2026: 29 · 2025: 32 · 2024: 52 · 2023: 50 · 2022: 38 · 2021: 57 · 2020: 51 · 2019: 40 · 2018: 26 · 2017: 29 · 2016: 13
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Infections and bacterial resistance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Keywords
- Stenotrophomonas maltophilia, antimicrobial resistance, multidrug resistance, opportunistic infections, biofilm formation, beta-lactamase, qnr genes, class 1 integron, efflux pumps, trimethoprim-sulfamethoxazole, fluoroquinolone resistance, tetracycline, tigecycline, doxycycline, minocycline, ceftazidime, ticarcillin-clavulanic acid, combination therapy, immunocompromised patients, cystic fibrosis, central venous catheters, emerging pathogens
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review