The DOI matches its Crossref record; 76 of the 77 references it cites were found in a registry or an index.
Assessing the Risk of Probiotic Dietary Supplements in the Context of Antibiotic Resistance
Open accessAbstract
Probiotic bacteria are known to harbor intrinsic and mobile genetic elements that confer resistance to a wide variety of antibiotics. Their high amounts in dietary supplements can establish a reservoir of antibiotic resistant genes in the human gut. These resistant genes can be transferred to pathogens that share the same intestinal habitat thus resulting in serious clinical ramifications. While antibiotic resistance of probiotic bacteria from food, human and animal sources have been well-documented, the resistant profiles of probiotics from dietary supplements have only been recently studied. These products are consumed with increasing regularity due to their health claims that include the improvement of intestinal health and immune response as well as prevention of acute and antibiotic-associated diarrhea and cancer; but, a comprehensive risk assessment on the spread of resistant genes to human health is lacking. Here, we highlight recent reports of antibiotic resistance of probiotic bacteria isolated from dietary supplements, and propose complementary strategies that can shed light on the risks of consuming such products in the context of a global widespread of antibiotic resistance. In concomitant with a broader screening of antibiotic resistance in probiotic supplements is the use of computational simulations, live imaging and functional genomics to harvest knowledge on the evolutionary behavior, adaptations and dynamics of probiotics studied in conditions that best represent the human gut including in the presence of antibiotics. The underlying goal is to enable the health benefits of probiotics to be exploited in a responsible manner and with minimal risk to human health.
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“Previous studies have shown that commercial probiotic products may contain ARGs or transferable resistance determinants, although the level of risk varies substantially among product types, bacterial taxa and analytical pipelines [15,16,17,18,19,20].”
From Integrated Phenotypic and Sequencing-Based Resistome Assessment of Antimicrobial Resistance Determinants in a Sample of Commercial Farm-Animal Probiotic Products (2026) · cites this paper as [15]
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“previous studies have shown that probiotic products and probiotic-associated taxa may carry detectable ARGs, but that public-health relevance depends on taxon identity, gene function, genomic context and mobility potential rather than on ARG counts alone [15,16,17,18,22,23].”
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Citations
Cites
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Items 201–218 of 218
Far, M. S. E., Zakaria, A. S., Kassem, M. A., Wedn, A., Guimei, M., & Edward, E. A. (2023) · Figshare · doi:10.6084/m9.figshare.22757370
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Far, M. S. E., Zakaria, A. S., Kassem, M. A., & Edward, E. A. (2024) · Figshare · doi:10.6084/m9.figshare.26698372
Far, M. S. E., Zakaria, A. S., Kassem, M. A., Wedn, A., Guimei, M., & Edward, E. A. (2023) · Figshare · doi:10.6084/m9.figshare.22757364
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Empfehlungen zur Ernährung von Personen mit Typ-1-Diabetes mellitus
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Empfehlungen zur Ernährung von Personen mit Typ-2-Diabetes mellitus
Skurk, T., Bosy‐Westphal, A., Grünerbel, A., Kabisch, S., Keuthage, W., Kleinridders, A., Kronsbein, P., Müssig, K., Nussbaumer, H., Pfeiffer, A. F. H., et al. (2025) · Diabetologie und Stoffwechsel · doi:10.1055/a-2592-8207
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Empfehlungen zur Ernährung von Personen mit Typ-2-Diabetes mellitus
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Shidhaye, S. S., Chaudhary, A. A., Gautam, Y., Chafle, V., Patil, H., Umekar, M. J., Rudayni, H. A., & Trivedi, R. (2026) · Future Microbiology · doi:10.1080/17460913.2026.2749225
Empfehlungen zur Ernährung von Personen mit Typ-1-Diabetes mellitus – Praxisempfehlung der DDG
Rubin, D. F., Bosy‐Westphal, A., Kabisch, S., Kronsbein, P., Müssig, K., Simon, M., Tombek, A., Weber, K. S., & Skurk, T. (2026) · Diabetologie und Stoffwechsel · doi:10.1055/a-2874-4204
Ahmed, M., Mishra, B., Panda, S. K., Muthupandian, S., & Mohanta, Y. K. (2026) · Frontiers in Antibiotics · doi:10.3389/frabi.2026.1901804
Metadata
- Authors
- Zheng, M., Zhang, R., Tian, X., Zhou, X., Pan, X., & Wong, A.
- Affiliations
- Wenzhou-Kean University (CN)
- Corresponding author
- Wong, Aloysius
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2017-05-19
- Volume
- 8
- Pages
- 908-908
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC5437161
- OpenAlex
- W2616265506
- Cited by
- 218
- References
- 77
- Citations by year
- 2026: 15 · 2025: 27 · 2024: 34 · 2023: 33 · 2022: 31 · 2021: 27 · 2020: 25 · 2019: 15 · 2018: 8 · 2017: 2
- FWCI
- 15.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Keywords
- probiotics, dietary supplements, antibiotic resistance, antibiotic resistance genes, mobile genetic elements, gut microbiota, horizontal gene transfer, risk assessment, human health risk
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