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Cited by 218Probiotics and Fermented FoodsAntibiotic Resistance in BacteriaAntibiotic Use and Resistance

The DOI matches its Crossref record; 76 of the 77 references it cites were found in a registry or an index.

Assessing the Risk of Probiotic Dietary Supplements in the Context of Antibiotic Resistance

Open access
Zheng, Min, Zhang, Ruijia, Tian, Xuechen, Zhou, Xuan, Pan, Xutong, Wong, Aloysius·2017·Frontiers in Microbiology
DOI 10.3389/fmicb.2017.00908PMC PMC5437161
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Abstract

Probiotic bacteria are known to harbor intrinsic and mobile genetic elements that confer resistance to a wide variety of antibiotics. Their high amounts in dietary supplements can establish a reservoir of antibiotic resistant genes in the human gut. These resistant genes can be transferred to pathogens that share the same intestinal habitat thus resulting in serious clinical ramifications. While antibiotic resistance of probiotic bacteria from food, human and animal sources have been well-documented, the resistant profiles of probiotics from dietary supplements have only been recently studied. These products are consumed with increasing regularity due to their health claims that include the improvement of intestinal health and immune response as well as prevention of acute and antibiotic-associated diarrhea and cancer; but, a comprehensive risk assessment on the spread of resistant genes to human health is lacking. Here, we highlight recent reports of antibiotic resistance of probiotic bacteria isolated from dietary supplements, and propose complementary strategies that can shed light on the risks of consuming such products in the context of a global widespread of antibiotic resistance. In concomitant with a broader screening of antibiotic resistance in probiotic supplements is the use of computational simulations, live imaging and functional genomics to harvest knowledge on the evolutionary behavior, adaptations and dynamics of probiotics studied in conditions that best represent the human gut including in the presence of antibiotics. The underlying goal is to enable the health benefits of probiotics to be exploited in a responsible manner and with minimal risk to human health.

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Crossref · 10.3389/fmicb.2017.00908

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FIGURE 1 A survey of (A) public and (B) academic interests of “probiotic supplements” (red), “food supplements” (blue), and “probiotics” (green) within the past 15 years (2004-February 2017). The keywords “probiotic supplements,” “food supplements,” and “probiotics” were used in the survey of public interest using Google Trends (https://trends.google.com/trends/) and to retrieve scholarly articles indexed in the PubMed database. The number of articles and Google Trend hits are normalized against the highest values of the respective search terms within the period between 2004 and February 2017.
FIGURE 1 A survey of (A) public and (B) academic interests of “probiotic supplements” (red), “food supplements” (blue), and “probiotics” (green) within the past 15 years (2004-February 2017). The keywords “probiotic supplements,” “food supplements,” and “probiotics” were used in the survey of public interest using Google Trends (https://trends.google.com/trends/) and to retrieve scholarly articles indexed in the PubMed database. The number of articles and Google Trend hits are normalized against the highest values of the respective search terms within the period between 2004 and February 2017.CC BY · PubMed Central
FIGURE 2 A proposed scheme of workflow illustrating the use of (A) live imaging technologies to visualize and track the growth and evolution of probiotic bacteria in real-time (Baym et al., 2016), (B,C) advanced molecular tools for the broad coverage and high resolution system level detection and gene expression analysis (Marondedze et al., 2014) and (D) powerful computational approaches for the formation of predictive models simulating the behavior of probiotic bacteria based on laboratory data (Waclaw, 2016), for the assessment of the risk of antibiotic resistance contributed by commercial probiotic strains and their long-term consumption to human health. This integrative approach should be applied in studies that consider the different compositions of the gut microflora such as the presence of a consortia of probiotic strains and pathogens as well as a gradient of antibiotic pressures, and their growth and colonization dynamics in response to various spatial and temporal factors.
FIGURE 2 A proposed scheme of workflow illustrating the use of (A) live imaging technologies to visualize and track the growth and evolution of probiotic bacteria in real-time (Baym et al., 2016), (B,C) advanced molecular tools for the broad coverage and high resolution system level detection and gene expression analysis (Marondedze et al., 2014) and (D) powerful computational approaches for the formation of predictive models simulating the behavior of probiotic bacteria based on laboratory data (Waclaw, 2016), for the assessment of the risk of antibiotic resistance contributed by commercial probiotic strains and their long-term consumption to human health. This integrative approach should be applied in studies that consider the different compositions of the gut microflora such as the presence of a consortia of probiotic strains and pathogens as well as a gradient of antibiotic pressures, and their growth and colonization dynamics in response to various spatial and temporal factors.CC BY · PubMed Central

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Metadata

Authors
Zheng, M., Zhang, R., Tian, X., Zhou, X., Pan, X., & Wong, A.
Affiliations
Wenzhou-Kean University (CN)
Corresponding author
Wong, Aloysius
ORCID
Venue
Frontiers in Microbiology
Publisher
Frontiers Media SA
Published
2017-05-19
Volume
8
Pages
908-908
ISSN
1664-302X (ISSN-L)
DOI
10.3389/fmicb.2017.00908
PMC
PMC5437161
OpenAlex
W2616265506
Cited by
218
References
77
Citations by year
2026: 15 · 2025: 27 · 2024: 34 · 2023: 33 · 2022: 31 · 2021: 27 · 2020: 25 · 2019: 15 · 2018: 8 · 2017: 2
FWCI
15.39
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Microbiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
  • Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
Keywords
probiotics, dietary supplements, antibiotic resistance, antibiotic resistance genes, mobile genetic elements, gut microbiota, horizontal gene transfer, risk assessment, human health risk

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