The DOI matches its Crossref record; 174 of the 174 references it cites were found in a registry or an index.
Review: Lessons Learned From Clinical Trials Using Antimicrobial Peptides (AMPs)
Open accessAbstract
Antimicrobial peptides (AMPs) or host defense peptides protect the host against various pathogens such as yeast, fungi, viruses and bacteria. AMPs also display immunomodulatory properties ranging from the modulation of inflammatory responses to the promotion of wound healing. More interestingly, AMPs cause cell disruption through non-specific interactions with the membrane surface of pathogens. This is most likely responsible for the low or limited emergence of bacterial resistance against many AMPs. Despite the increasing number of antibiotic-resistant bacteria and the potency of novel AMPs to combat such pathogens, only a few AMPs are in clinical use. Therefore, the current review describes (i) the potential of AMPs as alternatives to antibiotics, (ii) the challenges toward clinical implementation of AMPs and (iii) strategies to improve the success rate of AMPs in clinical trials, emphasizing the lessons we could learn from these trials.
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Cites
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Cited by
Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics
Murugaiyan, J., Kumar, P. A., Rao, G. S., Iskandar, K., Hawser, S., Hays, J. P., Mohsen, Y., Adukkadukkam, S., Awuah, W. A., Jose, R. A. M., et al. (2022) · Antibiotics · doi:10.3390/antibiotics11020200 · Cited by 567
Antimicrobial Peptides—Mechanisms of Action, Antimicrobial Effects and Clinical Applications
Talapko, J., Meštrović, T., Juzbašić, M., Tomas, M., Erić, S., Horvat Aleksijević, L., Bekić, S., Schwarz, D., Matić, S., Neuberg, M., et al. (2022) · Antibiotics · doi:10.3390/antibiotics11101417 · Cited by 281
Pandi, A., Adam, D., Zare, A., Trinh, V. T., Schaefer, S. L., Burt, M., Klabunde, B., Bobkova, E., Kushwaha, M., Foroughijabbari, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42434-9 · Cited by 173
Rossetti, P., Trollmann, M. F. W., Wichmann, C., Gutsmann, T., Eggeling, C., & Böckmann, R. A. (2026) · Small · doi:10.1002/smll.202411476 · Cited by 25
Metadata
- Authors
- Dijksteel, G. S., Ulrich, M. M. W., Middelkoop, E., & Boekema, B. K. H. L.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2021-02-22
- Volume
- 12
- Pages
- 616979-616979
- ISSN
- 1664-302X (ISSN-L)
- OpenAlex
- W3131431845
- Cited by
- 428
- References
- 174
- FWCI
- 36.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Dijksteel, G. S., Ulrich, M. M. W., Middelkoop, E., & Boekema, B. K. H. L. (2021). Review: Lessons Learned From Clinical Trials Using Antimicrobial Peptides (AMPs). Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2021.616979
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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