The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Antimicrobial Peptides: An Emerging Category of Therapeutic Agents
Open accessAbstract
Antimicrobial peptides (AMPs), also known as host defense peptides, are short and generally positively charged peptides found in a wide variety of life forms from microorganisms to humans. Most AMPs have the ability to kill microbial pathogens directly, whereas others act indirectly by modulating the host defense systems. Against a background of rapidly increasing resistance development to conventional antibiotics all over the world, efforts to bring AMPs into clinical use are accelerating. Several AMPs are currently being evaluated in clinical trials as novel anti-infectives, but also as new pharmacological agents to modulate the immune response, promote wound healing, and prevent post-surgical adhesions. In this review, we provide an overview of the biological role, classification, and mode of action of AMPs, discuss the opportunities and challenges to develop these peptides for clinical applications, and review the innovative formulation strategies for application of AMPs.
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Cites
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Brogden, K. A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1098 · Cited by 5,829
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
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Innate antimicrobial peptide protects the skin from invasive bacterial infection
Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., & Gallo, R. L. (2001) · Nature · doi:10.1038/35106587 · Cited by 1,198
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Cited by
Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review
Mulani, M. S., Kamble, E. E., Kumkar, S. N., Tawre, M. S., & Pardesi, K. R. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00539 · Cited by 1,644
Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions
Mohammad, S., & Thiemermann, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594150 · Cited by 585
Lima, P. G., Oliveira, J. T. A., Amaral, J. L., Freitas, C. D. T., & Souza, P. F. N. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119647 · Cited by 170
Review of the safety of application of cosmetic products containing parabens
Matwiejczuk, N., Galicka, A., & Brzóska, M. M. (2020) · Journal of Applied Toxicology · doi:10.1002/jat.3917 · Cited by 166
Borrelli, L., Varriale, L., Dipineto, L., Pace, A., Menna, L. F., & Fioretti, A. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.620798 · Cited by 175
Metadata
- Authors
- Mahlapuu, M., Håkansson, J., Ringstad, L., & Björn, C.
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2016-12-27
- Volume
- 6
- Pages
- 194-194
- ISSN
- 2235-2988 (ISSN-L)
- OpenAlex
- W2562261325
- Cited by
- 1,927
- References
- 7
- FWCI
- 88.25
- Type
- journal article
- Language
- en
- Open access
- gold
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- Mahlapuu, M., Håkansson, J., Ringstad, L., & Björn, C. (2016). Antimicrobial Peptides: An Emerging Category of Therapeutic Agents. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2016.00194
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
