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Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
Open accessAbstract
Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug efflux pumps exist in bacteria. Also, the co-crystal structural analysis of multidrug efflux pumps revealed the drug recognition and export mechanisms, and the inhibitory mechanisms of the pumps. A single multidrug efflux pump can export multiple antibiotics; hence, developing efflux pump inhibitors is crucial in overcoming infectious diseases caused by multidrug-resistant bacteria. This review article describes the role of multidrug efflux pumps in MDR, and their physiological functions and inhibitory mechanisms.
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Cites
Iron and bacterial virulence–a brief overview.
Griffiths, E. (1991) · Biology of Metals · doi:10.1007/bf01135551 · Cited by 86
Cited by
Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview
Huang, L., Wu, C., Gao, H., Xu, C., Dai, M., Huang, L., Hao, H., Wang, X., & Cheng, G. (2022) · Antibiotics · doi:10.3390/antibiotics11040520 · Cited by 284
Strategies for combating antibiotic resistance in bacterial biofilms
Grooters, K. E., Ku, J. C., Richter, D. M., Krinock, M. J., Minor, A., Li, P., Kim, A., Sawyer, R., & Li, Y. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1352273 · Cited by 156
Metadata
- Authors
- Nishino, K., Yamasaki, S., Nakashima, R., Zwama, M., & Hayashi-Nishino, M.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2021-12-03
- Volume
- 12
- Pages
- 737288-737288
- ISSN
- 1664-302X (ISSN-L)
- OpenAlex
- W3217358971
- Cited by
- 229
- References
- 1
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- gold
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- Nishino, K., Yamasaki, S., Nakashima, R., Zwama, M., & Hayashi-Nishino, M. (2021). Function and Inhibitory Mechanisms of Multidrug Efflux Pumps. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2021.737288
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