The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview
Open accessAbstract
Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by decreasing the intracellular concentration of drugs. This protective barrier consists of a series of transporter proteins, which are located in the bacterial cell membrane and periplasm and remove diverse extraneous substrates, including antimicrobials, organic solvents, toxic heavy metals, etc., from bacterial cells. This review systematically and comprehensively summarizes the functions of multiple efflux pumps families and discusses their potential applications. The biological functions of efflux pumps including their promotion of multidrug resistance, biofilm formation, quorum sensing, and survival and pathogenicity of bacteria are elucidated. The potential applications of efflux pump-related genes/proteins for the detection of antibiotic residues and antimicrobial resistance are also analyzed. Last but not least, efflux pump inhibitors, especially those of plant origin, are discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria
Hall, C. W., & Mah, T.-F. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux010 · Cited by 1,696
The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria
Li, X.-Z., Plésiat, P., & Nikaido, H. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00117-14 · Cited by 1,614
Multidrug-resistance efflux pumps ? not just for resistance
Piddock, L. J. V. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1464 · Cited by 1,522
Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants
Blanco, P., Hernando-Amado, S., Reales-Calderon, J., Corona, F., Lira, F., Alcalde-Rico, M., Bernardini, A., Sanchez, M., & Martinez, J. (2016) · Microorganisms · doi:10.3390/microorganisms4010014 · Cited by 663
Role of bacterial efflux pumps in biofilm formation
Alav, I., Sutton, J. M., & Rahman, K. M. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky042 · Cited by 504
Multidrug Efflux Pumps in Staphylococcus aureus: an Update
Costa, S. S., Viveiros, M., Amaral, L., & Couto, I. (2013) · The Open Microbiology Journal · doi:10.2174/1874285801307010059 · Cited by 409
Multidrug efflux transporters in the MATE family
Kuroda, T., & Tsuchiya, T. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2008.11.012 · Cited by 396
Small multidrug resistance proteins: A multidrug transporter family that continues to grow
Bay, D. C., Rommens, K. L., & Turner, R. J. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.015 · Cited by 299
Recent advances toward a molecular mechanism of efflux pump inhibition
Opperman, T. J., & Nguyen, S. T. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00421 · Cited by 266
Genetic analysis of an MDR-like export system: the secretion of colicin V.
Gilson, L., Mahanty, H. K., & Kolter, R. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07606.x · Cited by 237
Cited by
Antimicrobial peptides for combating drug-resistant bacterial infections
Xuan, J., Feng, W., Wang, J., Wang, R., Zhang, B., Bo, L., Chen, Z.-S., Yang, H., & Sun, L. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.100954 · Cited by 665
Moiseenko, K. V., Glazunova, O. A., Savinova, O. S., & Fedorova, T. V. (2024) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683824606012 · Cited by 4
Metadata
- Authors
- Huang, L., Wu, C., Gao, H., Xu, C., Dai, M., Huang, L., Hao, H., Wang, X., & Cheng, G.
- Venue
- Antibiotics
- Publisher
- MDPI AG
- Published
- 2022-04-13
- Volume
- 11
- Issue
- 4
- Pages
- 520
- ISSN
- 2079-6382 (ISSN-L)
- OpenAlex
- W4223937116
- Cited by
- 284
- References
- 107
- FWCI
- 13.59
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview. https://app.cochat.ai/papers/10.3390/antibiotics11040520
- The paper
- Huang, L., Wu, C., Gao, H., Xu, C., Dai, M., Huang, L., Hao, H., Wang, X., & Cheng, G. (2022). Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview. Antibiotics. https://doi.org/10.3390/antibiotics11040520
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
