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Cited by 146Microbial Metabolic Engineering and BioproductionMicrobial Community Ecology and PhysiologyMicrobial bioremediation and biosurfactants

Construction of Environmental Synthetic Microbial Consortia: Based on Engineering and Ecological Principles

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Liang, Yu, Ma, Anzhou, Zhuang, Guoqiang·2022·Frontiers in Microbiology
DOI 10.3389/fmicb.2022.829717PMC PMC8905317
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Abstract

In synthetic biology, engineering principles are applied to system design. The development of synthetic microbial consortia represents the intersection of synthetic biology and microbiology. Synthetic community systems are constructed by co-cultivating two or more microorganisms under certain environmental conditions, with broad applications in many fields including ecological restoration and ecological theory. Synthetic microbial consortia tend to have high biological processing efficiencies, because the division of labor reduces the metabolic burden of individual members. In this review, we focus on the environmental applications of synthetic microbial consortia. Although there are many strategies for the construction of synthetic microbial consortia, we mainly introduce the most widely used construction principles based on cross-feeding. Additionally, we propose methods for constructing synthetic microbial consortia based on traits and spatial structure from the perspective of ecology to provide a basis for future work.

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Cited by

Sorted by citations

Authors
Liang, Y., Ma, A., & Zhuang, G.
Affiliations
Chinese Academy of Sciences (CN)
Corresponding author
Ma, Anzhou
ORCID
Venue
Frontiers in Microbiology
Publisher
Frontiers Media SA
Published
2022-02-23
Volume
13
Pages
829717-829717
ISSN
1664-302X (ISSN-L)
DOI
10.3389/fmicb.2022.829717
PMC
PMC8905317
OpenAlex
W4214638575
Cited by
146
References
1
Citations by year
2026: 62 · 2025: 44 · 2024: 21 · 2023: 13 · 2022: 6
FWCI
2.21
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Microbiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Key Research and Development Program of China (2018YFA0901200)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
  • Physical Sciences › Environmental Science › Pollution › Microbial bioremediation and biosurfactants
Keywords
synthetic microbial consortia, synthetic microbial communities, co-culture, cross-feeding, division of labor, ecological restoration, spatial structure, microbial ecology, environmental biotechnology, metabolic burden

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