The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
Advances in silver nanoparticles: a comprehensive review on their potential as antimicrobial agents and their mechanisms of action elucidated by proteomics
Open accessAbstract
Nanoparticles play a crucial role in the field of nanotechnology, offering different properties due to their surface area attributed to their small size. Among them, silver nanoparticles (AgNPs) have attracted significant attention due to their antimicrobial properties, with applications that date back from ancient medicinal practices to contemporary commercial products containing ions or silver nanoparticles. AgNPs possess broad-spectrum biocidal potential against bacteria, fungi, viruses, and Mycobacterium, in addition to exhibiting synergistic effects when combined with certain antibiotics. The mechanisms underlying its antimicrobial action include the generation of oxygen-reactive species, damage to DNA, rupture of bacterial cell membranes and inhibition of protein synthesis. Recent studies have highlighted the effectiveness of AgNPs against various clinically relevant bacterial strains through their potential to combat antibiotic-resistant pathogens. This review investigates the proteomic mechanisms by which AgNPs exert their antimicrobial effects, with a special focus on their activity against planktonic bacteria and in biofilms. Furthermore, it discusses the biomedical applications of AgNPs and their potential non-preparation of antibiotic formulations, also addressing the issue of resistance to antibiotics.
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“Recent reviews outline proteomic stress responses and dosing strategies that balance antimicrobial activity with host safety [195,196].”
From Understanding Pseudomonas aeruginosa Biofilms: Quorum Sensing, c-di-GMP Signaling, and Emerging Antibiofilm Approaches (2026) · cites this paper as [195]
In the citing paper
“AgNPs damage membranes, respiratory enzymes, and nucleic acids and act synergistically with standard antibiotics against MDR P. aeruginosa.”
From Understanding Pseudomonas aeruginosa Biofilms: Quorum Sensing, c-di-GMP Signaling, and Emerging Antibiofilm Approaches (2026) · cites this paper as [195]
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Cites
Nanoparticles: Properties, applications and toxicities
Khan, I., Saeed, K., & Khan, I. (2019) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2017.05.011 · Cited by 6,244
Zhang, X.-F., Liu, Z.-G., Shen, W., & Gurunathan, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091534 · Cited by 3,220
Prabhu, S., & Poulose, E. K. (2012) · International Nano Letters · doi:10.1186/2228-5326-2-32 · Cited by 2,278
Mechanistic Basis of Antimicrobial Actions of Silver Nanoparticles
Dakal, T. C., Kumar, A., Majumdar, R. S., & Yadav, V. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01831 · Cited by 2,135
Joudeh, N., & Linke, D. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01477-8 · Cited by 1,908
Silver Nanoparticles and Their Antibacterial Applications
Bruna, T., Maldonado-Bravo, F., Jara, P., & Caro, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137202 · Cited by 1,708
Proteomic Analysis of the Mode of Antibacterial Action of Silver Nanoparticles
Lok, C.-N., Ho, C.-M., Chen, R., He, Q.-Y., Yu, W.-Y., Sun, H., Tam, P. K.-H., Chiu, J.-F., & Che, C.-M. (2006) · Journal of Proteome Research · doi:10.1021/pr0504079 · Cited by 1,581
Metal-Based Nanoparticles as Antimicrobial Agents: An Overview
Sánchez-López, E., Gomes, D., Esteruelas, G., Bonilla, L., Lopez-Machado, A. L., Galindo, R., Cano, A., Espina, M., Ettcheto, M., Camins, A., et al. (2020) · Nanomaterials · doi:10.3390/nano10020292 · Cited by 1,474
Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview
Burdușel, A.-C., Gherasim, O., Grumezescu, A. M., Mogoantă, L., Ficai, A., & Andronescu, E. (2018) · Nanomaterials · doi:10.3390/nano8090681 · Cited by 1,343
Bacterial resistance to silver nanoparticles and how to overcome it
Panáček, A., Kvítek, L., Smékalová, M., Večeřová, R., Kolář, M., Röderová, M., Dyčka, F., Šebela, M., Prucek, R., Tomanec, O., et al. (2018) · Nature Nanotechnology · doi:10.1038/s41565-017-0013-y · Cited by 963
Cited by
Elbehiry, A., Marzouk, E., Edrees, H. M., Ibrahem, M., Alzahrani, S., Anagreyyah, S., Abualola, H., Alghamdi, A., Alzahrani, A., Jaber, M., et al. (2026) · Microorganisms · doi:10.3390/microorganisms14010109 · Cited by 34
Metadata
- Authors
- Rodrigues, A. S., Batista, J. G. S., Rodrigues, M. Á. V., Thipe, V. C., Minarini, L. A. R., Lopes, P. S., & Lugão, A. B.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2024-07-31
- Volume
- 15
- Pages
- 1440065-1440065
- ISSN
- 1664-302X (ISSN-L)
- OpenAlex
- W4401194380
- Cited by
- 346
- References
- 119
- FWCI
- 32.75
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Rodrigues, A. S., Batista, J. G. S., Rodrigues, M. Á. V., Thipe, V. C., Minarini, L. A. R., Lopes, P. S., & Lugão, A. B. (2024). Advances in silver nanoparticles: a comprehensive review on their potential as antimicrobial agents and their mechanisms of action elucidated by proteomics. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2024.1440065
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
