Toxicological Effects of Berberine and Sanguinarine

Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine

Imanshahidi, M., & Hosseinzadeh, H. (2008) · Phytotherapy Research · doi:10.1002/ptr.2399 · Cited by 636

A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species

Küpeli̇, E., Koşar, M., Yeşilada, E., & Başer, K. H. C. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02200-2 · Cited by 379

In vitro biological assessment of berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects

El-Wahab, A. E. A., Ghareeb, D. A., Sarhan, E. M., Abu-Serie, M. M., & Demellawy, M. E. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-218 · Cited by 250

Anti-Inflammatory Drugs and Herbs with Special Emphasis on Herbal Medicines for Countering Inflammatory Diseases and Disorders - A Review

Yatoo, M. I., Gopalakrishnan, A., Saxena, A., Parray, O. R., Tufani, N. A., Chakraborty, S., Tiwari, R., Dhama, K., & Iqbal, H. M. N. (2018) · Recent Patents on Inflammation & Allergy Drug Discovery · doi:10.2174/1872213x12666180115153635 · Cited by 246

Differential antiproliferative and apoptotic response of sanguinarine for cancer cells versus normal cells.

Ahmad, N., Gupta, S., Husain, M. M., Heiskanen, K. M., & Mukhtar, H. (2000) · PubMed · Cited by 224

Berberis crataegina DC. root exhibits potent anti-inflammatory, analgesic and febrifuge effects in mice and rats

Yeşilada, E., & Küpeli̇, E. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(01)00387-7 · Cited by 203

Cytotoxic Effects of Bangladeshi Medicinal Plant Extracts

Uddin, S. J., Grice, I. D., & Tiralongo, E. (2009) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nep111 · Cited by 192

Effects and mechanisms of berberine in diabetes treatment

Yin, J., Ye, J., & Jia, W. (2012) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2012.06.003 · Cited by 183

Berberine hydrochloride: anticancer activity and nanoparticulate delivery system

Tan, W., Li, Chen, M., & Wang, Y. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s22683 · Cited by 176

Argemone mexicana: Chemical and pharmacological aspects

Brahmachari, G., Gorai, D., & Roy, R. (2013) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2013005000021 · Cited by 163

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

Porras, G., Chassagne, F., Lyles, J. T., Marquez, L., Dettweiler, M., Salam, A. M., Samarakoon, T., Shabih, S., Farrokhi, D. R., & Quave, C. L. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00922 · Cited by 415

Berberine as a Potential Anticancer Agent: A Comprehensive Review

Rauf, A., Abu‐Izneid, T., Khalil, A. A., Imran, M., Shah, Z. A., Emran, T. B., Mitra, S., Khan, Z., Alhumaydhi, F. A., Aljohani, A. S. M., et al. (2021) · Molecules · doi:10.3390/molecules26237368 · Cited by 304

Inhibition of inflammation by berberine: Molecular mechanism and network pharmacology analysis

Wang, K., Yin, J., Chen, J., Ma, J., Si, H., & Xia, D. (2024) · Phytomedicine · doi:10.1016/j.phymed.2023.155258 · Cited by 301

The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents

Hobson, C., Chan, A. N., & Wright, G. D. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01214 · Cited by 229

Biological Activity of Berberine—A Summary Update

Och, A., Podgórski, R., & Nowak, R. (2020) · Toxins · doi:10.3390/toxins12110713 · Cited by 223

Fungal Endophytes as Efficient Sources of Plant-Derived Bioactive Compounds and Their Prospective Applications in Natural Product Drug Discovery: Insights, Avenues, and Challenges

Singh, A. K., Singh, D. K., Kharwar, R. N., White, J. F., & Gond, S. K. (2021) · Microorganisms · doi:10.3390/microorganisms9010197 · Cited by 198

Targeting aging mechanisms: pharmacological perspectives

Moskalev, A., Guvatova, Z., Lopes, I. D. A., Beckett, C. W., Kennedy, B. K., De Magalhaes, J. P., & Makarov, A. A. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2022.01.007 · Cited by 164

In-vitro analysis of free radical scavenging activities and suppression of LPS-induced ROS production in macrophage cells by Solanum sisymbriifolium extracts

More, G. K., & Makola, R. T. (2020) · Scientific Reports · doi:10.1038/s41598-020-63491-w · Cited by 151

Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases

Plazas, E., Murillo, M. C. Á., Muñoz-Cendales, D. R., & Suárez, L. E. C. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106126 · Cited by 152

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

Peng, J., Zheng, T., Li, X., Liang, Y., Wang, L., Huang, Y., & Xiao, H. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00351 · Cited by 135

Neuroprotective Properties of Berberine: Molecular Mechanisms and Clinical Implications

Tian, E., Sharma, G., & Dai, C. (2023) · Antioxidants · doi:10.3390/antiox12101883 · Cited by 137

Berberine treatment reduces atherosclerosis by mediating gut microbiota in apoE-/- mice

Shi, Y., Hu, J., Geng, J., Hu, T., Wang, B., Yan, W., Jiang, Y., Li, J., & Liu, S. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.148 · Cited by 111

Nanotechnology-Based Strategies for Berberine Delivery System in Cancer Treatment: Pulling Strings to Keep Berberine in Power

Iqbal, M. J., Quispe, C., Javed, Z., Sadia, H., Qadri, Q. R., Raza, S., Salehi, B., Martins, N. A., Mohamed, Z. A., Mohammed, J. S., et al. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.624494 · Cited by 106

Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease

Och, A., Och, M., Nowak, R., Podgórska, D., & Podgórski, R. (2022) · Molecules · doi:10.3390/molecules27041351 · Cited by 104

Antioxidant Berberine-Derivative Inhibits Multifaceted Amyloid Toxicity

Rajasekhar, K., Samanta, S., Bagoband, V., Murugan, N. A., & Govindaraju, T. (2020) · iScience · doi:10.1016/j.isci.2020.101005 · Cited by 100

Berberine and Its Study as an Antidiabetic Compound

Utami, A. R., Maksum, I. P., & Deawati, Y. (2023) · Biology · doi:10.3390/biology12070973 · Cited by 110

Escaping mechanisms of ESKAPE pathogens from antibiotics and their targeting by natural compounds

Jadimurthy, R., Mayegowda, S. B., Nayak, S. C., Mohan, C. D., & Rangappa, K. S. (2022) · Biotechnology Reports · doi:10.1016/j.btre.2022.e00728 · Cited by 103

Molecular Mechanisms of Sanguinarine in Cancer Prevention and Treatment

Ullah, A., Aziz, T., Ullah, N., & Nawaz, T. (2022) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520622666220831124321 · Cited by 93

Neuroprotective potential of berberine in modulating Alzheimer’s disease via multiple signaling pathways

Akbar, M., Shabbir, A., Rehman, K., Akash, M. S. H., & Shah, M. A. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13936 · Cited by 97

Photonic and magnetic materials for on-demand local drug delivery

Armenia, I., Cuestas-Ayllón, C., Torres‐Herrero, B., Bussolari, F., Alfranca, G., Grazú, V., & de la Fuente, J. M. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114584 · Cited by 82

Sanguinarine modulate gut microbiome and intestinal morphology to enhance growth performance in broilers

Liu, Z., Wang, X., Ou, S.-Q., Hou, D., & He, J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234920 · Cited by 74

Herbal Therapies for Cancer Treatment: A Review of Phytotherapeutic Efficacy

Jenča, A., Mills, D. K., Ghasemi, H., Saberian, E., Jenča, A., Forood, A. M. K., Petrášová, A., Jenčová, J., Velisdeh, Z. J., Zare‐Zardini, H., et al. (2024) · Biologics · doi:10.2147/btt.s484068 · Cited by 75

Synergic Effects of Berberine and Curcumin on Improving Cognitive Function in an Alzheimer’s Disease Mouse Model

Lin, L., Cheng, L., Zhang, D., Yuan, M., Chen, C., & Li, M. (2020) · Neurochemical Research · doi:10.1007/s11064-020-02992-6 · Cited by 72

An Update of the Sanguinarine and Benzophenanthridine Alkaloids’ Biosynthesis and Their Applications

Laines-Hidalgo, J. I., Muñoz-Sánchez, J. A., Loza-Müller, L., & Vázquez‐Flota, F. (2022) · Molecules · doi:10.3390/molecules27041378 · Cited by 62

The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids

Kooshki, L., Zarneshan, S. N., Fakhri, S., Moradi, S. Z., & Echeverría, J. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154686 · Cited by 66

Cytotoxic and Proapoptotic Activity of Sanguinarine, Berberine, and Extracts of Chelidonium majus L. and Berberis thunbergii DC. toward Hematopoietic Cancer Cell Lines

Och, A., Zalewski, D. P., Komsta, Ł., Kołodziej, P., Kocki, J., & Bogucka‐Kocka, A. (2019) · Toxins · doi:10.3390/toxins11090485 · Cited by 61

Mixed biofilms of pathogenic Candida-bacteria: regulation mechanisms and treatment strategies

Khan, F., Bamunuarachchi, N. I., Pham, D. T. N., Tabassum, N., Khan, M. S., & Kim, Y. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1921696 · Cited by 63

Berberine Slows the Progression of Prediabetes to Diabetes in Zucker Diabetic Fatty Rats by Enhancing Intestinal Secretion of Glucagon-Like Peptide-2 and Improving the Gut Microbiota

Wang, Y., Liu, H., Zheng, M., Yang, Y., Ren, H., Kong, Y., Wang, S., Wang, J., Jiang, Y., Yang, J., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.609134 · Cited by 61

Bioactivity and mechanism of action of sanguinarine and its derivatives in the past 10 years

Huang, L.-J., Lan, J., Wang, J., Huang, H., Lu, K., Zhou, Z.-N., Xin, S., Zhang, Z., Wang, J.-Y., Dai, P., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116406 · Cited by 58

Advanced Computational Methodologies Used in the Discovery of New Natural Anticancer Compounds

Chavda, V. P., Ertaş, Y. N., Walhekar, V. S., Modh, D. H., Doshi, A., Shah, N., Anand, K., & Chhabria, M. T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.702611 · Cited by 59

A bird's eye view on a therapeutically ‘wonder molecule’: Berberine

Patel, P. K. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100070 · Cited by 57

Berberine-Loaded Liposomes for the Treatment of Leishmania infantum-Infected BALB/c Mice

Calvo, A., Moreno, E., Larrea, E., Sanmartín, C., Irache, J. M., & Espuelas, S. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12090858 · Cited by 54

A Review of Fibraurea tinctoria and Its Component, Berberine, as an Antidiabetic and Antioxidant

Purwaningsih, I., Maksum, I. P., Sumiarsa, D., & Sriwidodo, S. (2023) · Molecules · doi:10.3390/molecules28031294 · Cited by 63

Sanguinarine has anthelmintic activity against the enteral and parenteral phases of trichinella infection in experimentally infected mice

Huang, H., Yao, J., Liu, K., Yang, W., Wang, G., Shi, C., Jiang, Y., Wang, J., Kang, Y., Wang, D., et al. (2019) · Acta Tropica · doi:10.1016/j.actatropica.2019.105226 · Cited by 53

Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections

Pacyga, K., Pacyga, P., Topola, E., Viscardi, S., & Duda-Madej, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042100 · Cited by 57

Developmental toxicity caused by sanguinarine in zebrafish embryos via regulating oxidative stress, apoptosis and wnt pathways

Yang, X., Wang, X., Gao, D., Zhang, Y. L., Chen, X., Xia, Q., Jin, M., Sun, C., He, Q., Wang, R., et al. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2021.07.001 · Cited by 48

Antibacterial activity and mechanism of sanguinarine against Providencia rettgeri in vitro

Zhang, Q., Lyu, Y., Huang, J., Zhang, X., Yu, N. H., Wen, Z., & Chen, S. (2020) · PeerJ · doi:10.7717/peerj.9543 · Cited by 51

Berberine Ameliorates Subarachnoid Hemorrhage Injury via Induction of Sirtuin 1 and Inhibiting HMGB1/Nf-κB Pathway

Zhang, X.-H., Peng, L., Zhang, J., Dong, Y., Wang, C., Liu, C., Xia, D., & Zhang, X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01073 · Cited by 46

AMPK in microvascular complications of diabetes and the beneficial effects of AMPK activators from plants

Basavarajappa, S. C., & Nandini, C. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.12.031 · Cited by 47

Quantification of Berberine in Berberis vulgaris L. Root Extract and Its Curative and Prophylactic Role in Cisplatin-Induced In Vivo Toxicity and In Vitro Cytotoxicity

Ahmad, S., Hussain, A., Hussain, A., Abdullah, I., Ali, M. S., Froeyen, M., & Mirza, M. U. (2019) · Antioxidants · doi:10.3390/antiox8060185 · Cited by 46

A Mechanistic Review on How Berberine Use Combats Diabetes and Related Complications: Molecular, Cellular, and Metabolic Effects

Askari, V. R., Khosravi, K., Rahimi, V. B., & Garzoli, S. (2023) · Pharmaceuticals · doi:10.3390/ph17010007 · Cited by 49

Palmatine as an Agent Against Metabolic Syndrome and Its Related Complications: A Review

Ekeuku, S. O., Pang, K.-L., & Chin, K. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s280520 · Cited by 46

Evaluation of the Cytotoxic Activity and Anti-Migratory Effect of Berberine–Phytantriol Liquid Crystalline Nanoparticle Formulation on Non-Small-Cell Lung Cancer In Vitro

Alnuqaydan, A. M., Almutary, A. G., Azam, M., Manandhar, B., Yin, G. H. S., Yen, L., Madheswaran, T., Paudel, K. R., Hansbro, P. M., Chellappan, D. K., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061119 · Cited by 44

Phytantriol-Based Berberine-Loaded Liquid Crystalline Nanoparticles Attenuate Inflammation and Oxidative Stress in Lipopolysaccharide-Induced RAW264.7 Macrophages

Alnuqaydan, A. M., Almutary, A. G., Azam, M., Manandhar, B., Rubis, G. D., Madheswaran, T., Paudel, K. R., Hansbro, P. M., Chellappan, D. K., & Dua, K. (2022) · Nanomaterials · doi:10.3390/nano12234312 · Cited by 44

Alkaloids unveiled: A comprehensive analysis of novel therapeutic properties, mechanisms, and plant-based innovations

Sarvananda, L., Madhuranga, H. D. T., Madhurangi, B. L. N. K., Premarathna, A. D., & Saravanan, M. (2024) · Intelligent Pharmacy · doi:10.1016/j.ipha.2024.09.007 · Cited by 44

A Mechanistic Evaluation of Antioxidant Nutraceuticals on Their Potential against Age-Associated Neurodegenerative Diseases

Ramli, N. Z., Yahaya, M. F., Tooyama, I., & Damanhuri, H. A. (2020) · Antioxidants · doi:10.3390/antiox9101019 · Cited by 43

Synergistic Effect of Berberine Hydrochloride and Fluconazole Against Candida albicans Resistant Isolates

Yong, J., Zu, R., Huang, X., Ge, Y., & Li, Y. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01498 · Cited by 44

Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases

Sahebnasagh, A., Eghbali, S., Saghafi, F., Sureda, A., & Avan, R. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00292-x · Cited by 42

Role of Berberine Thermosensitive Hydrogel in Periodontitis via PI3K/AKT Pathway In Vitro

Wang, C., Liu, C., Chen, L., Qu, X., Zou, X., Du, S., Zhang, Q., & Wang, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076364 · Cited by 40

The state of oligomerization of Rubisco controls the rate of synthesis of the Rubisco large subunit in Chlamydomonas reinhardtii

Wietrzyñski, W., Traverso, E., Wollman, F.-A., & Wostrikoff, K. (2021) · The Plant Cell · doi:10.1093/plcell/koab061 · Cited by 40

Unlocking the potential of Berberine: Advancing cancer therapy through chemosensitization and combination treatments

Sajeev, A., Sailo, B., Unnikrishnan, J., Talukdar, A., Alqahtani, M. S., Abbas, M. A. E., Alqahtani, A., Sethi, G., & Kunnumakkara, A. B. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217019 · Cited by 41

Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria

Qassadi, F. I., Zhu, Z., & Monaghan, T. M. (2023) · Pathogens · doi:10.3390/pathogens12020333 · Cited by 41

Sanguinarine synergistically potentiates aminoglycoside‐mediated bacterial killing

Lu, C., Zhang, N., Kou, S.-H., Gao, L., Peng, B., Dai, Y., & Zheng, J. (2022) · Microbial Biotechnology · doi:10.1111/1751-7915.14017 · Cited by 36

A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis

Berton, S., Chen, L., Liang, Y. C., Xu, Z., Afriyie-Asante, A., Rajabalee, N., Yang, W., & Sun, J. (2022) · Cell chemical biology · doi:10.1016/j.chembiol.2022.03.006 · Cited by 35

Complexation-induced tuning of optical properties of a medically important alkaloid, berberine in the presence of charged cyclodextrin

Chakraborty, G., Pillai, V. S., & Chittela, R. K. (2021) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2021.113454 · Cited by 34

Natural Antibacterial and Antivirulence Alkaloids From Macleaya cordata Against Methicillin-Resistant Staphylococcus aureus

Liu, Z., Wang, W.-M., Zhang, Z., Sun, L., & Wu, S.-C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.813172 · Cited by 33

Mycobacterium tuberculosis Exploits Focal Adhesion Kinase to Induce Necrotic Cell Death and Inhibit Reactive Oxygen Species Production

Afriyie-Asante, A., Dabla, A., Dagenais, A., Berton, S., Smyth, R., & Sun, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.742370 · Cited by 32

Biotechnological Approaches to Optimize the Production of Amaryllidaceae Alkaloids

Koirala, M., Karimzadegan, V., Liyanage, N. S., Mérindol, N., & Desgagné‐Penix, I. (2022) · Biomolecules · doi:10.3390/biom12070893 · Cited by 33

Sanguinarine Induces Apoptosis in Papillary Thyroid Cancer Cells via Generation of Reactive Oxygen Species

Khan, A. Q., Mohamed, E. A. N., Hakeem, I., Nazeer, A., Kuttikrishnan, S., Prabhu, K. S., Siveen, K. S., Nawaz, Z., Ahmad, A., Zayed, H., et al. (2020) · Molecules · doi:10.3390/molecules25051229 · Cited by 31

The neuroprotective role of morroniside against spinal cord injury in female rats

Duan, F., Shi, Y., Chen, J., Song, X., Shen, L., Qi, Q., Ding, S., Wang, Q., Wang, R., Lü, H., et al. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105105 · Cited by 31

Antibiofilm activity of phytochemicals against Enterococcus faecalis : A literature review

Ali, I. A. A., & Neelakantan, P. (2022) · Phytotherapy Research · doi:10.1002/ptr.7488 · Cited by 36

Inhibitory effects of berberine on fungal growth, biofilm formation, virulence, and drug resistance as an antifungal drug and adjuvant with prospects for future applications

Ding, J., Yan, Z., Peng, L., Li, J., Yang, F., & Zheng, D. (2024) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-024-04223-4 · Cited by 29

Berberine Attenuates Arterial Plaque Formation in Atherosclerotic Rats with Damp-Heat Syndrome via Regulating Autophagy

Ke, X., Huang, Y., Li, L., Xin, F., Xu, L., Zhang, Y., Zeng, Z., Lin, F., & Song, Y. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s250524 · Cited by 28

Exploring alkaloids and flavonoids from natural sources: Emerging natural agents for inhibiting cervical cancer progression through apoptosis induction, anti-inflammatory effects, and oxidative stress reduction

Chen, Y., Yu, D., Zhu, D., Muthusamy, S., Deshpande, M., Kiruthiga, N., Theivendren, P., Rajalakshmi, K., Wu, S., & Zhu, C. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156092 · Cited by 27

The short-term effects of berberine in the liver: Narrow margins between benefits and toxicity

Moreira, E. S., Ames-Sibin, A. P., Bonetti, C. I., Leal, L. E., Peralta, R. M., de Sá‐Nakanishi, A. B., Comar, J. F., Bracht, A., & Bracht, L. (2022) · Toxicology Letters · doi:10.1016/j.toxlet.2022.08.005 · Cited by 27

DNA G-Quadruplexes as Targets for Natural Product Drug Discovery

Wang, K., Wang, Y., Dickerhoff, J., & Yang, D. (2024) · Engineering · doi:10.1016/j.eng.2024.03.015 · Cited by 28

Cooperative enhancement of antibacterial activity of sanguinarine drug through p -sulfonatocalix[6]arene functionalized silver nanoparticles

Mehra, C., Gala, R., Kakatkar, A. S., Kumar, V., Khurana, R., Chatterjee, S., Kumar, N. N., Barooah, N., Bhasikuttan, A. C., & Mohanty, J. (2019) · Chemical Communications · doi:10.1039/c9cc07378g · Cited by 26

The Synergistic Effect of Piperlongumine and Sanguinarine on the Non-Small Lung Cancer

Hałas‐Wiśniewska, M., Zielińska, W., Izdebska, M., & Grzanka, A. (2020) · Molecules · doi:10.3390/molecules25133045 · Cited by 26

Berberine in Human Oncogenic Herpesvirus Infections and Their Linked Cancers

Šudomová, M., Berchová‐Bímová, K., Marzocco, S., Líšková, A., Kubatka, P., & Hassan, S. T. S. (2021) · Viruses · doi:10.3390/v13061014 · Cited by 26

In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer’s Disease

Amat-ur-Rasool, H., Ahmed, M., Hasnain, S., Ahmed, A., & Carter, W. G. (2021) · Current Issues in Molecular Biology · doi:10.3390/cimb44010012 · Cited by 28

In Vitro and In Vivo Biological Activity of Berberine Chloride against Uropathogenic E. coli Strains Using Galleria mellonella as a Host Model

Petronio, G. P., Cutuli, M. A., Magnifico, I., Venditti, N., Pietrangelo, L., Vergalito, F., Pane, A., Scapagnini, G., & Marco, R. D. (2020) · Molecules · doi:10.3390/molecules25215010 · Cited by 25

Neurotoxicity of sanguinarine via inhibiting mitophagy and activating apoptosis in zebrafish and PC12 cells

Yang, X., Li, L., Shi, Y., Wang, X. B., Zhang, Y. L., Jin, M., Chen, X., Wang, R., & Liu, K. (2022) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2022.105259 · Cited by 25

Insights on Antitumor Activity and Mechanism of Natural Benzophenanthridine Alkaloids

Peng, R., Xu, M., Xie, B., Min, Q., Hui, S., Du, Z., Liu, Y., Yu, W., Wang, S., Chen, X., et al. (2023) · Molecules · doi:10.3390/molecules28186588 · Cited by 25

Natural Excipients in Pharmaceutical Formulations

Singh, P. N. D., Mishra, G., & Dinda, S. C. (2021) · Springer eBooks · doi:10.1007/978-981-15-8127-4_40 · Cited by 24

Characterizing the cytotoxic effects and several antimicrobial phytocompounds of Argemone mexicana

Orozco-Nunnelly, D. A., Pruet, J., Ríos-Ibarra, C. P., Gamarra, E. L. B., Lefeber, T., & Najdeska, T. (2021) · PLoS ONE · doi:10.1371/journal.pone.0249704 · Cited by 26

Cardiotoxicity of sanguinarine via regulating apoptosis and MAPK pathways in zebrafish and HL1 cardiomyocytes

Wang, X. B., Yang, X., Wang, J., Li, L., Zhang, Y. L., Jin, M., Chen, X., Sun, C., Wang, R., & Liu, K. (2021) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2021.109228 · Cited by 24

Sanguinarine induces apoptosis in Eimeria tenella sporozoites via the generation of reactive oxygen species

Li, J., Huang, H., Pan, T., Wang, N., Shi, C., Zhang, B., Wang, C., & Yang, G. (2022) · Poultry Science · doi:10.1016/j.psj.2022.101771 · Cited by 24

Berberine promotes the viability of random skin flaps via the PI3K/Akt/eNOS signaling pathway

Chen, J., Jiang, Z., Liu, X., Wang, K., Fan, W., Chen, T., Li, Z., & Lin, D. (2022) · Phytotherapy Research · doi:10.1002/ptr.7621 · Cited by 24

A toxicological review of alkaloids

Yang, N., Guo, J., Zhang, J., Gao, S. W., Xiang, Q., Wen, J., Huang, Y., Rao, C., & Chen, Y. (2024) · Drug and Chemical Toxicology · doi:10.1080/01480545.2024.2326051 · Cited by 23

Unraveling Berberine's Molecular Mechanisms in Neuroprotection Against Neurodegeneration

Begh, M. Z. A., Amin, M. A., Shatu, M. M., Sweilam, S. H., Puri, S., Ramesh, R. B., Arjun, U. V. N. V., Shanmugarajan, T. S., Pommala, N., Durairaj, A., et al. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202500170 · Cited by 24

Sanguinarine caused larval lethality and growth inhibition by suppressing energy metabolism in silkworms, Bombyx mori

Li, P., Hu, J., Wen, C., Hang, Y., Zhou, Z., Xie, M., Lv, J., Wang, C., Huang, Y., Xu, J., et al. (2019) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2019.08.004 · Cited by 23

Bioactive molecules from fungal endophytes and their applications in pharmaceutical industries: challenges and future scope

Anand, K., Kumar, V., Prasher, I. B., Sethi, M., Raj, H., Ranjan, H., Chand, S., & Pandey, G. K. (2023) · Journal of Basic Microbiology · doi:10.1002/jobm.202200696 · Cited by 23

Targeting Intracellular Bacteria with Dual Drug-loaded Lactoferrin Nanoparticles

Andima, M., Boese, A. S., Paul, P., Koch, M., Loretz, B., & Lehr, C. (2024) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.4c00045 · Cited by 24

Mucoadhesive Chitosan Delivery System with Chelidonii Herba Lyophilized Extract as a Promising Strategy for Vaginitis Treatment

Paczkowska‐Walendowska, M., Chanaj-Kaczmarek, J., Romaniuk-Drapała, A., Rubiś, B., Szymanowska, D., Kobus‐Cisowska, J., Szymańska, E., Winnicka, K., & Cielecka‐Piontek, J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041208 · Cited by 23

Supramolecular modulation in photophysical features of berberine and its application towards ATP sensing

Chakraborty, G., Chittela, R. K., Jonnalgadda, P. N., & Pal, H. (2022) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2022.119316 · Cited by 21

Sanguinarine Exhibits Antiviral Activity against Porcine Reproductive and Respiratory Syndrome Virus via Multisite Inhibition Mechanisms

Ke, Q., Duan, K., Cheng, Y. F., Xu, S., Xiao, S., & Fang, L. (2023) · Viruses · doi:10.3390/v15030688 · Cited by 21

Berberine as a Bioactive Alkaloid: Multi-Omics Perspectives on Its Role in Obesity Management

Zieniuk, B., & Pawełkowicz, M. E. (2025) · Metabolites · doi:10.3390/metabo15070467 · Cited by 24

Oxyberberine an oxoderivative of berberine confers neuroprotective effects in controlled-cortical impact mouse model of traumatic brain injury

Tentu, P. M., Bazaz, M. R., Pasam, T., Shaikh, A. S., Rahman, Z., Mourya, A., Kaki, V. R., Madan, J., & Dandekar, M. P. (2023) · International Journal of Neuroscience · doi:10.1080/00207454.2023.2286209 · Cited by 20

Relationship between the therapeutic potential of various plant-derived bioactive compounds and their related microRNAs in neurological disorders

Dong, X., & Nao, J. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154501 · Cited by 18

Antidiabetic bioactive natural products from medicinal plants

Tresina, P. S., Selvam, M. S., Döss, A., & Mohan, V. R. (2022) · Studies in natural products chemistry · doi:10.1016/b978-0-323-91250-1.00004-5 · Cited by 21

Berberine's impact on health: Comprehensive biological, pharmacological, and nutritional perspectives

Asghari, P., Babaei, A., Zamanian, N., & Nattagh‐Eshtivani, E. (2025) · Metabolism Open · doi:10.1016/j.metop.2025.100399 · Cited by 23

Nanocomplex of Berberine with C60 Fullerene Is a Potent Suppressor of Lewis Lung Carcinoma Cells Invasion In Vitro and Metastatic Activity In Vivo

Horak, I. R., Prylutska, S., Krysiuk, I. P., Lugovskyi, S. P., Hrabovsky, O., Tverdokhleb, N., Franskevych, D., Rumiantsev, D., Senenko, A., Evstigneev, M. P., et al. (2021) · Materials · doi:10.3390/ma14206114 · Cited by 18

Berberine: Is it a Promising Agent for Mental Disorders Treatment?

Shayganfard, M. (2022) · Current Molecular Pharmacology · doi:10.2174/1874467215666220509213122 · Cited by 18

Insights into the potential of Sanguinarine as a promising therapeutic option for breast cancer

Malla, R. R., Bhamidipati, P., & Adem, M. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115565 · Cited by 18

Management of triple-negative breast cancer by natural compounds through different mechanistic pathways

Kaleem, M., Thool, M., Dumore, N. G., Abdulrahman, A. O., Ahmad, W., Almostadi, A., Alhashmi, M. H., Kamal, M. A., & Tabrez, S. S. M. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1440430 · Cited by 18

Argemone species: Potential source of biofuel and high-value biological active compounds

Martínez-Delgado, A. A., de Anda, J., León‐Morales, J. M., Mateos‐Díaz, J. C., Gutiérrez-Mora, A., & Castañeda‐Nava, J. J. (2021) · Environmental Engineering Research · doi:10.4491/eer.2020.619 · Cited by 17

Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation

Shu, D., Zhu, Y., Meng, L., He, A., Chen, J.-B., Ye, D.-S., Liu, Y., Zeng, X., Ma, R., & Ming, Z. (2021) · Biomedicines · doi:10.3390/biomedicines9050444 · Cited by 17

Low molecular weight fucoidan modified nanoliposomes for the targeted delivery of the anti-inflammation natural product berberine

Liu, L., Xing, R. S., Xue, J., Fan, J., Zou, J., Song, X., Jia, R., Zou, Y., Li, L., Zhou, X., et al. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123102 · Cited by 17

Toxic Effects of Penetrating Cations

Соколов, С. С., Zyrina, A. N., Akimov, S. A., Кнорре, Д. А., & Severin, F. F. (2023) · Membranes · doi:10.3390/membranes13100841 · Cited by 16

Toll-like receptors in inflammatory bowel disease: A review of the role of phytochemicals

Esmaealzadeh, N., Ram, M., Abdolghaffari, A., Marques, A. M., & Bahramsoltani, R. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155178 · Cited by 17

Infrared Spectrum and Sites of Action of Sanguinarine by Molecular Mechanics and ab initio Methods

Gobato, R. (2018) · International Journal of Atmospheric and Oceanic Sciences · doi:10.11648/j.ijaos.20180201.11 · Cited by 24

Research Progress on Effects of Sanguinarine on Pharmacology and Toxicology

Wang, H. (2012) · China Animal Husbandry & Veterinary Medicine · Cited by 1

Interaction of benzo[c]phenanthridine and protoberberine alkaloids with animal and yeast cells

Slaninová, I., Táborská, E., Bochořáková, H., & Slanina, J. (2001) · Cell Biology and Toxicology · doi:10.1023/a:1010907231602 · Cited by 94

Short‐term toxicity studies of Sanguinarine and of two alkaloid extracts ofSanguinaria CanadensisL.

Becci, P. J., Schwartz, H. M., Barnes, H. H., & Southard, G. L. (1987) · Journal of Toxicology and Environmental Health · doi:10.1080/15287398709530972 · Cited by 62

[The toxicity of sanguinarine compared to a number of other DNA-tropic compounds for ethidium bromide-sensitive and -resistant transformed murine fibroblasts in culture].

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