Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease

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Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease

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Toxicological Effects of Berberine and Sanguinarine

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Berberine and neurodegeneration: A review of literature

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Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study

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Berberine-induced bioactive metabolites of the gut microbiota improve energy metabolism

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Berberine is an insulin secretagogue targeting the KCNH6 potassium channel

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Metformin and berberine, two versatile drugs in treatment of common metabolic diseases

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Berberine suppresses colon cancer cell proliferation by inhibiting the SCAP/SREBP-1 signaling pathway-mediated lipogenesis

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Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption

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The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells

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SCFA Receptors in Pancreatic β Cells: Novel Diabetes Targets?

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Berberine could inhibit thyroid carcinoma cells by inducing mitochondrial apoptosis, G0/G1 cell cycle arrest and suppressing migration via PI3K-AKT and MAPK signaling pathways

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Berberine Directly Affects the Gut Microbiota to Promote Intestinal Farnesoid X Receptor Activation

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Berberine: Pathways to protect neurons

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The use of berberine for women with polycystic ovary syndrome undergoing <scp>IVF</scp> treatment

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Berberine improves insulin resistance in cardiomyocytes via activation of 5′-adenosine monophosphate-activated protein kinase

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Antiangiogenic activity of berberine is mediated through the downregulation of hypoxia-inducible factor-1, VEGF, and proinflammatory mediators

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p38α MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine

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Berberine and Tinospora cordifolia exert a potential anticancer effect on colon cancer cells by acting on specific pathways

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Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3.

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Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters

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Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats

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Induction of G1 cell cycle arrest and apoptosis by berberine in bladder cancer cells

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Restoration of GLP-1 secretion by Berberine is associated with protection of colon enterocytes from mitochondrial overheating in diet-induced obese mice

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Metformin and Berberine Prevent Olanzapine-Induced Weight Gain in Rats

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A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome

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Plant Isoquinoline Alkaloid Berberine Exhibits Chromatin Remodeling by Modulation of Histone Deacetylase To Induce Growth Arrest and Apoptosis in the A549 Cell Line

Kalaiarasi, A., Anusha, C., Renu, S., Rajasekaran, S., Marshal, J. J., Muthusamy, K., & Ravikumar, V. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04453 · Cited by 75 · see citing works

Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma

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Resistant starch from high amylose maize (HAM-RS2) and Dietary butyrate reduce abdominal fat by a different apparent mechanism

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Critical Role for FoxO3a-Dependent Regulation of p21 CIP1/WAF1 in Response to Statin Signaling in Cardiac Myocytes

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Berberine mitigates high glucose-induced podocyte apoptosis by modulating autophagy via the mTOR/P70S6K/4EBP1 pathway

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Effect and mechanism of berberine against polycystic ovary syndrome

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Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer

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Dose-response effect of berberine on bile acid profile and gut microbiota in mice

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Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses

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Abnormal Involuntary Movement Scale (AIMS) and Extrapyramidal Symptom Rating Scale (ESRS): Cross-scale comparison in assessing tardive dyskinesia

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Update on the Benefits and Mechanisms of Action of the Bioactive Vegetal Alkaloid Berberine on Lipid Metabolism and Homeostasis

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Mitochondria and NMDA Receptor-Dependent Toxicity of Berberine Sensitizes Neurons to Glutamate and Rotenone Injury

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Berberine induces apoptosis in non-small-cell lung cancer cells by upregulating miR-19a targeting tissue factor

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Berberine enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast cancer

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Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy

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MAPK pathways are involved in the inhibitory effect of berberine hydrochloride on gastric cancer MGC 803 cell proliferation and IL-8 secretion in vitro and in vivo

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Berberine inhibits proliferation and migration of colorectal cancer cells by downregulation of GRP78

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Cytotoxic and Proapoptotic Activity of Sanguinarine, Berberine, and Extracts of Chelidonium majus L. and Berberis thunbergii DC. toward Hematopoietic Cancer Cell Lines

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Jun and Fos family protein expression in human breast cancer: correlation of protein expression and clinicopathological parameters.

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Cytotoxicity of berberine on human cervical carcinoma HeLa cells through mitochondria, death receptor and MAPK pathways, and in-silico drug-target prediction

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Effects of a New Nutraceutical Formulation (Berberine, Red Yeast Rice and Chitosan) on Non-HDL Cholesterol Levels in Individuals with Dyslipidemia: Results from a Randomized, Double Blind, Placebo-Controlled Study

Spigoni, V., Aldigeri, R., Antonini, M., Micheli, M., Fantuzzi, F., Fratter, A., Pellizzato, M., Derlindati, E., Zavaroni, I., Bonadonna, R. C., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071498 · Cited by 60 · see citing works

Preparation and Evaluation of Antidiabetic Agents of Berberine Organic Acid Salts for Enhancing the Bioavailability

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Effect of Berberine on Cardiovascular Disease Risk Factors: A Mechanistic Randomized Controlled Trial

Zhao, J. V., Yeung, W.-F., Chan, Y.-H., Vackova, D., Leung, J. Y. Y., Ip, D. K. M., Zhao, J., Ho, W.-K., Tse, H.-F., & Schooling, C. M. (2021) · Nutrients · doi:10.3390/nu13082550 · Cited by 58 · see citing works

Effects of Poly-Bioactive Compounds on Lipid Profile and Body Weight in a Moderately Hypercholesterolemic Population with Low Cardiovascular Disease Risk: A Multicenter Randomized Trial

Solà, R., Valls, R. M., Puzo, J., Calabuig, J.-R., Brea, Á., Pedret, A., Moriña, D., Villar, J. R., Millán, J., & Anguera, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101978 · Cited by 56 · see citing works

Subcutaneous adipose tissue biology in metabolic syndrome

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Expression of the jun family of genes in human ovarian cancer and normal ovarian surface epithelium.

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New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis

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Efficacy and safety of berberine alone or combined with statins for the treatment of hyperlipidemia: A systematic review and meta-analysis of randomized controlled clinical trials

Zhang, L.-S., Zhang, J.-H., Feng, R., Jin, X.-Y., Yang, F.-W., Ji, Z.-C., Zhao, M.-Y., Zhang, M.-Y., Zhang, B.-L., & Li, X.-M. (2019) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x19500393 · Cited by 50 · see citing works

Efficacy and Tolerability of a Nutraceutical Combination (Red Yeast Rice, Policosanols, and Berberine) in Patients with Low-Moderate Risk Hypercholesterolemia: A Double-Blind, Placebo-Controlled Study

Gonnelli, S., Caffarelli, C., Stolakis, K., Cuda, C., Giordano, N. G., & Nuti, R. (2014) · Current Therapeutic Research · doi:10.1016/j.curtheres.2014.07.003 · Cited by 49 · see citing works

Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia

Wu, N., Sarna, L. K., Siow, Y. L., & Karmin, O. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00441.2010 · Cited by 49 · see citing works

Randomized controlled trial of letrozole, berberine, or a combination for infertility in the polycystic ovary syndrome

Wu, X.-K., Wang, Y., Liu, J., Liang, R.-N., Xue, H.-Y., Ma, H.-X., Shao, X., Ng, E. H. Y., Hou, L., Wang, Y.-Y., et al. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.05.022 · Cited by 48 · see citing works

Berberine inhibits WEHI-3 leukemia cells in vivo.

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Increased mast cell abundance in adipose tissue of metabolic syndrome: relevance to the proinflammatory state and increased adipose tissue fibrosis

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Effects of a New Combination of Nutraceuticals with Morus alba on Lipid Profile, Insulin Sensitivity and Endotelial Function in Dyslipidemic Subjects. A Cross-Over, Randomized, Double-Blind Trial

Trimarco, V., Izzo, R., Stabile, E., Rozza, F., Santoro, M., Manzi, M. V., Serino, F., Schiattarella, G. G., Esposito, G., & Trimarco, B. (2015) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-015-0087-2 · Cited by 46 · see citing works

c-Jun Expression and Activation are Restricted to CD30+ Lymphoproliferative Disorders

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Increased eosinophils in adipose tissue of metabolic syndrome

Moussa, K., Gurung, P., ADAMS-HUET, B. A., Devaraj, S., & Jialal, I. (2019) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2019.05.010 · Cited by 43 · see citing works

Berberine Inhibits Proliferative Ability of Breast Cancer Cells by Reducing Metadherin

Sun, Y., Wang, W., & Tong, Y. (2019) · Medical Science Monitor · doi:10.12659/msm.914486 · Cited by 40 · see citing works

Effects of a nutraceutical combination on lipids, inflammation and endothelial integrity in patients with subclinical inflammation: a randomized clinical trial

Pirro, M., Mannarino, M. R., Ministrini, S., Fallarino, F., Lupattelli, G., Bianconi, V., Bagaglia, F., & Mannarino, E. (2016) · Scientific Reports · doi:10.1038/srep23587 · Cited by 39 · see citing works

Berberine induces dose-dependent quiescence and apoptosis in A549 cancer cells by modulating cell cyclins and inflammation independent of mTOR pathway

Kumar, R., Awasthi, M., Sharma, A., Padwad, Y. S., & Sharma, R. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117346 · Cited by 39 · see citing works

The prevalence of metabolic syndrome amongst patients with severe mental illness in the community in Hong Kong – a cross sectional study

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Metabolic Syndrome in Severe Mental Disorders

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Growth-Inhibiting Effects of Coptis japonica Root-Derived Isoquinoline Alkaloids on Human Intestinal Bacteria

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Metabolic syndrome, diabetes and cardiovascular events: current controversies and recommendations.

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Exploratory metabolomics of nascent metabolic syndrome

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Bererine induces peripheral lymphocytes immune regulations to realize its neuroprotective effects in the cerebral ischemia/reperfusion mice

Song, B., Tang, X., Wang, X., Huang, X., Ye, Y., Lu, X., Wei, X., & Zeng, Y. (2012) · Cellular Immunology · doi:10.1016/j.cellimm.2012.04.006 · Cited by 34 · see citing works

Berberine sensitizes human glioma cells, but not normal glial cells, to ionizing radiation in vitro.

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Effect of berberine on insulin resistance in women with polycystic ovary syndrome: study protocol for a randomized multicenter controlled trial

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Long non‑coding RNA CASC2 enhances berberine‑induced cytotoxicity in colorectal cancer cells by silencing BCL2

Dai, W., Mu, L.-Y., Cui, Y., Li, Y., Chen, P., Xie, H., & Wang, X. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10326 · Cited by 33 · see citing works

Berberine Inhibits MDA‐MB‐231 Cells by Attenuating Their Inflammatory Responses

Zhao, L., & Zhang, C. (2020) · BioMed Research International · doi:10.1155/2020/3617514 · Cited by 32 · see citing works

Berberine Suppressed Tumor Growth through Regulating Fatty Acid Metabolism and Triggering Cell Apoptosis via Targeting FABPs

Li, L., Peng, Z., Hu, Q., Xu, L., Zou, X. G., Yu, Y., Huang, D., & Yi, P. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/6195050 · Cited by 31 · see citing works

[Therapeutic Effects of Berberine Capsule on Patients with Mild Hyperlipidemia].

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An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia

Derosa, G., D’Angelo, A., Vanelli, A., & Maffioli, P. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s232791 · Cited by 26 · see citing works

Berberine induces double-strand DNA breaks in Rev3 deficient cells

Hu, X., Wu, X., Huang, Y., et al. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.1999 · Cited by 25 · see citing works

A 13-week low glycemic load diet and lifestyle modification program combining low glycemic load protein shakes and targeted nutraceuticals improved weight loss and cardio-metabolic risk factors

Dahlberg, C. J., Ou, J. J., Babish, J. G., Lamb, J. J., Eliason, S., Brabazon, H., Gao, W., Kaadige, M. R., & Tripp, M. L. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2016-0704 · Cited by 25 · see citing works

The role of enhancer of zeste homolog 2: From viral epigenetics to the carcinogenesis of hepatocellular carcinoma

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Prevention of Metabolic Syndrome in Serious Mental Illness

Ganguli, R., & Strassnig, M. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2010.11.004 · Cited by 22 · see citing works

Berberine possesses muscarinic agonist-like properties in cultured rodent cardiomyocytes

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The effect of berberine adjunctive treatment on glycolipid metabolism in patients with schizophrenia: A randomized, double-blind, placebo-controlled clinical trial

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Inhibitory Effects of Coptidis rhizoma and Berberine on Cocaine‐Induced Sensitization

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The Natural Compound Gambogic Acid Radiosensitizes Nasopharyngeal Carcinoma Cells under Hypoxic Conditions

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Abnormal activator protein 1 transcription factor expression in CD30-positive cutaneous large-cell lymphomas

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At the centre of things

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Efficacy and Safety of Berberine in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis

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Berberine and Monacolin Effects on the Cardiovascular Risk Profile of Women with Oestroprogestin-Induced Hypercholesterolemia

Cicero, A. F. G., Reggi, A., Parini, A., Morbini, M., Rosticci, M., Grandi, E., & Borghi, C. (2014) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-014-0052-5 · Cited by 12 · see citing works

Letrozole, berberine, or a combination for infertility in Chinese women with polycystic ovary syndrome: a multicentre, randomised, double-blind, placebo-controlled trial

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Editorial: Brain-Metabolic Crossroads in Severe Mental Disorders—Focus on Metabolic Syndrome

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The effect of berberine on insulin resistance in women with polycystic ovary syndrome: detailed statistical analysis plan (SAP) for a multicenter randomized controlled trial

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An assessor-blinded, randomized comparison of efficacy and tolerability of switching from olanzapine to ziprasidone and the combination of both in schizophrenia spectrum disorders

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SUN-PO004: Nutraceutical Intervention with Berberine, Chlorogenic Acid and Tocotrienols for Menopause-Associated Dyslipidemia: A Pilot, Single-ARM Trial

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Metabolic syndrome-related kidney injury: a review and update

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Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review

Dumitru, C. N., Marcu, T., Dumitru, A. O., Tudor, S. S., Ferțu, I. D., Elisei, A.-M., & Goroftei, L. (2026) · Pharmaceuticals · doi:10.3390/ph19081313 · Cited by 2 · see citing works

Berberine Contents as a Quality Marker in Medicinal Plants and Amounts of Berberine Passing into Serum

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Berberine through PPAR- γ/HO-1 Pathway Regulates Macrophage PolarizationPreprint

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Effects of Berberine on Lymphocyte Proliferation and GM-CSF Production in Mice.

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The metabolic syndrome: Insulin resistance

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Study of insulin status in metabolic syndrome in correlation with presence of other risk factors

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