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Cited by 28Histone Deacetylase Inhibitors ResearchEpigenetics and DNA MethylationGenomics and Chromatin Dynamics

HDAC4 in cancer: A multitasking platform to drive not only epigenetic modifications

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Cuttini, Emma, Goi, Camilla, Pellarin, Ester, Vida, Riccardo, Brancolini, Claudio·2023·Frontiers in Molecular Biosciences
DOI 10.3389/fmolb.2023.1116660PMC PMC9902726
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Abstract

Controlling access to genomic information and maintaining its stability are key aspects of cell life. Histone acetylation is a reversible epigenetic modification that allows access to DNA and the assembly of protein complexes that regulate mainly transcription but also other activities. Enzymes known as histone deacetylases (HDACs) are involved in the removal of the acetyl-group or in some cases of small hydrophobic moieties from histones but also from the non-histone substrate. The main achievement of HDACs on histones is to repress transcription and promote the formation of more compact chromatin. There are 18 different HDACs encoded in the human genome. Here we will discuss HDAC4, a member of the class IIa family, and its possible contribution to cancer development.

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Authors
Cuttini, E., Goi, C., Pellarin, E., Vida, R., & Brancolini, C.
Affiliations
University of Udine (IT)
Corresponding author
Brancolini, Claudio
ORCID
Brancolini, Claudio
Venue
Frontiers in Molecular Biosciences
Publisher
Frontiers Media SA
Published
2023-01-24
Volume
10
Pages
1116660-1116660
ISSN
2296-889X (ISSN-L)
DOI
10.3389/fmolb.2023.1116660
PMC
PMC9902726
OpenAlex
W4317820239
Cited by
28
References
230
Citations by year
2026: 4 · 2025: 6 · 2024: 13 · 2023: 5
FWCI
0.74
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Molecular Biosciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Institutional Research Information System (University of Udine) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Associazione Italiana per la Ricerca sul Cancro (IG 2021)
  • Interreg (ITAT1054)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
HDAC4, histone deacetylase, class IIa HDACs, histone acetylation, epigenetic modifications, chromatin condensation, transcriptional repression, carcinogenesis, non-histone substrates

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