The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Dopamine and Dopamine Receptors in Alzheimer's Disease: A Systematic Review and Network Meta-Analysis
Open accessAbstract
Objective: The aim of this review was to synthesize, using random-effects model of meta-analysis, the link between dopaminergic system and Alzheimer’s disease. Methods: A detailed analysis protocol was registered at the PROSPERO database prior to data extraction (CRD42018110798). Electronic databases of PubMed, Embase, Web of Science, and Psyc-ARTICLES were searched up to December 2018 for studies that examined dopamine and dopamine receptors in relation to Alzheimer’s disease. Standardized mean differences (SMD) were calculated to assess group differences in the levels of dopaminergic neurometabolites. Results: Seventeen studies met the eligibility criteria. Collectively, they included 512 patients and 500 healthy controls. There were significantly lower levels of dopamine in patients with Alzheimer’s disease compared with controls (SMD= -1.56, 95% CI: -2.64 to -0.49). In addition, dopamine 1 receptor (SMD=-5.05, 95% CI: -6.14 to -3.97) and dopamine 2 receptor (SMD=-1.13, 95% CI: -1.52 to -0.74) levels were decreased in patients with Alzheimer’s disease compared with controls. The results of network meta-analysis indicated that the rank of correlation with Alzheimer’s disease from highest to lowest was dopamine (0.74), dopamine 2 receptor (0.49), dopamine 3 receptor (0.46), dopamine 4 receptor (0.33), dopamine 5 receptor (0.31), and dopamine 1 receptor (0.64). Conclusions: Overall, decreased levels of dopaminergic neurotransmitters were linked with the pathophysiology of Alzheimer’s disease. Nonetheless, there is a clear need for more prospective studies to validate these hypotheses.
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Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
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Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
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Measuring inconsistency in meta-analyses
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Sex differences in Alzheimer disease — the gateway to precision medicine
for the Women’s Brain Project and the Alzheimer Precision Medicine Initiative, Ferretti, M. T., Iulita, M. F., Cavedo, E., Chiesa, P. A., Schumacher Dimech, A., Santuccione Chadha, A., Baracchi, F., Girouard, H., Misoch, S., et al. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0032-9 · Cited by 1,009
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Nobili, A., Latagliata, E. C., Viscomi, M. T., Cavallucci, V., Cutuli, D., Giacovazzo, G., Krashia, P., Rizzo, F. R., Marino, R., Federici, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms14727 · Cited by 514 · cited 1×
“For instance, it is widely accepted that dopamine, which derives from the ventral tegmental area (VTA) dopaminergic neurons, modulates and projects mainly cerebral cortex, nucleus accumbens and hippocampal functions, including control of voluntary movement, memory and synaptic plasticity (Nobili et al., 2017).”
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Cited by
Chen, C., Liao, J., Xia, Y., Liu, X., Jones, R., Haran, J., McCormick, B., Sampson, T. R., Alam, A., & Ye, K. (2022) · Gut · doi:10.1136/gutjnl-2021-326269 · Cited by 491
Akyuz, E., Arulsamy, A., Aslan, F. S., Sarisözen, B., Guney, B., Hekimoglu, A., Yilmaz, B. N., Retinasamy, T., & Shaikh, M. F. (2025) · Molecular Neurobiology · doi:10.1007/s12035-024-04333-y · Cited by 69
Wu, Y., Liu, Q., Qiu, Y., & Xie, L. (2022) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1010367 · Cited by 34
Preserved autophagy in cognitively intact non‐demented individuals with Alzheimer's neuropathology
Tumurbaatar, B., Fracassi, A., Scaduto, P., Guptarak, J., Woltjer, R., Jupiter, D., & Taglialatela, G. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.13074 · Cited by 32
Cross study transcriptomic investigation of Alzheimer’s brain tissue discoveries and limitations
Tsurukawa, F. K., Mao, Y., Sanchez-Villalobos, C., Khanna, N., Crasto, C. J., Lawrence, J. J., & Pal, R. (2025) · Scientific Reports · doi:10.1038/s41598-025-01017-y · Cited by 6
Metadata
- Authors
- Pan, X., Kaminga, A. C., Wen, S. W., Wu, X., Acheampong, K., & Liu, A.
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2019-07-11
- Volume
- 11
- Pages
- 175-175
- ISSN
- 1663-4365 (ISSN-L)
- OpenAlex
- W2956927868
- Cited by
- 268
- References
- 63
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pan, X., Kaminga, A. C., Wen, S. W., Wu, X., Acheampong, K., & Liu, A. (2019). Dopamine and Dopamine Receptors in Alzheimer's Disease: A Systematic Review and Network Meta-Analysis. Frontiers in Aging Neuroscience. https://doi.org/10.3389/fnagi.2019.00175
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