Thalamocortical Projection Neuron and Interneuron Numbers in the Visual Thalamic Nuclei of the Adult C57BL/6 Mouse
Open accessAbstract
A key parameter to constrain predictive, bottom-up circuit models of a given brain domain is the number and position of the neuronal populations involved. These include not only the neurons whose bodies reside within the domain, but also the neurons in distant regions that innervate the domain. The mouse visual cortex receives its main subcortical input from the dorsal lateral geniculate nucleus (dLGN) and the lateral posterior (LP) complex of the thalamus. The latter consists of three different nuclei: lateral posterior lateral (LPL), lateral posterior medial rostral (LPMR), and lateral posterior medial caudal (LPMC), each exhibiting specific patterns of connections with the various visual cortical areas. Here, we have determined the number of thalamocortical projection neurons and interneurons in the LP complex and dLGN of the adult C57BL/6 male mouse. We combined Nissl staining and histochemical and immunolabeling methods for consistently delineating nuclei borders, and applied unbiased stereological cell counting methods. Thalamic interneurons were identified using GABA immunolabeling. The C57BL/6 dLGN contains ∼21,200 neurons, while LP complex contains ∼31,000 total neurons. The dLGN and LP are the only nuclei of the mouse dorsal thalamus containing substantial numbers GABA-immunoreactive interneurons. These interneurons, however, are scarcer than previously estimated; they are 5.6% of dLGN neurons and just 1.9% of the LP neurons. It can be thus inferred that the dLGN contains ∼20,000 and the LP complex ∼30,400 thalamocortical projection neurons (∼12,000 in LPL, 15,200 in LPMR, and 4,200 in LPMC). The present dataset is relevant for constraining models of mouse visual thalamocortical circuits, as well as for quantitative comparisons between genetically modified mouse strains, or across species.
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Regions with higher mean activity and glucose demands tend to match those ROIs that swell.
“Regions with higher mean activity and glucose demands tend to match those ROIs that swell.”
From Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice (2026) · cites this paper as [49]
The Results section on dLGN and LP complex volume reports anatomical volume differences, not swelling of regions with higher mean activity or glucose demand. The Discussion section on volume speculates that the larger left dLGN might reflect lateralized sensory use, but does not test the claimed relationship. Searches for glucose metabolism, activity and swelling found no passage addressing it; page numbers were not available in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measuredPolarities of effects are linked to differences in metabolic rates.
“One plausible idea is that polarities of effects are linked to differences in metabolic rates49-51.”
From Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice (2026) · cites this paper as [49]
The Introduction discusses differences in neuron numbers between mouse strains, and the Discussion describes differences in labeling among visual thalamic nuclei; neither links the polarity of effects to metabolic rates. Searches for the quoted phrase and for metabolic rates or metabolism found no passage in our copy addressing that proposed link. No page numbers were provided for these passages. (LLM, conf=0.76)
Experimental — accuracy not yet measuredCortex and hippocampus have higher glucose utilization than globus pallidus, as do the three exceptional nuclei in thalamus, hypothalamus, and midbrain that all increase in volume-the LGD, SCH, and ICC.
“For example, cortex and hippocampus have higher glucose utilization than globus pallidus, as do the three exceptional nuclei in thalamus, hypothalamus, and midbrain that all increase in volume—the LGD, SCH, and ICC (Fig. 4a,b)49,50.”
From Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice (2026) · cites this paper as [49]
The Results section on dLGN and LP volume reports measurements and a left–right difference in dLGN volume, not an increase in volume across the three named nuclei. Searches for glucose utilization, globus pallidus, SCH, and ICC found no passage addressing the claimed comparisons. (LLM, conf=0.76)
Experimental — accuracy not yet measured
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- Authors
- Evangelio, M., García-Amado, M., & Clascá, F.
- Affiliations
- Universidad Autónoma de Madrid (ES)
- Corresponding author
- Clascá, Francisco
- ORCID
- Clascá, Francisco
- Venue
- Frontiers in Neuroanatomy
- Publisher
- Frontiers Media SA
- Published
- 2018-04-12
- Volume
- 12
- Pages
- 27-27
- ISSN
- 1662-5129 (ISSN-L)
- PMC
- PMC5906714
- OpenAlex
- W2797591839
- Cited by
- 61
- References
- 66
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 2 · 2023: 12 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 4 · 2018: 4
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Neuroanatomy (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Seventh Framework Programme (Grant Agreement No. 720270 HBP SGA1)
- Ministerio de Economça y Competitividad (BFU2017-88549)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- thalamic interneurons, GABAergic interneurons, dorsal lateral geniculate nucleus, thalamocortical circuits, C57BL/6 mice
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