Genetic Control of Interconnected Neuronal Populations in the Mouse Primary Visual System
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Proliferation and survival of different cell types is thought to be modulated by cell interactions during development that achieve numerical and functional balance. We tested the precision of coregulation of numbers of neurons, glial cells, and endothelial cells in the dorsal lateral geniculate nucleus (LGN) in 58 isogenic strains of mice. We acquired matched counts of retinal ganglion cells (RGCs) in these strains and tested the precision of numerical matching between retina and LGN. Cells were counted using unbiased counting protocols and tissue from the Mouse Brain Library (www.mbl.org). Classification criteria were assessed using immunohistochemical criteria. The LGN contains an average of 17,000 neurons, 12,000 glial cells, and 10,000 endothelial cells. Variation around these means is typically twofold, and cell ratios vary widely. Strain differences in LGN volume correlate moderately well with glial cell number (r= 0.69) and less well with RGC number (r= 0.35) and with LGN neuron number (r= 0.32). Populations of LGN neurons and glial cells correlate only modestly (r= 0.44;p< 0.01). The single most surprising and unequivocal finding was the lack of any detectable correlation between populations of LGN neurons and RGCs, a correlation of merely 0.01 across 56 strains. In contrast, RGC number correlates significantly with LGN glial cell number, a surprising twist on the numerical matching hypothesis (r= 0.33;p< 0.01). We conclude that numbers of these two functionally coupled neuron populations are modulated over a wide range by independent genetic and developmental mechanisms.
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Delineations of the dorsal lateral geniculate nucleus (LGD) of AD-BXD F1s have mean unilateral volumes of approximately 0.35 ± 0.04 SD mm3, whereas previous estimates of adult B6D2F1 hybrid from celloidin-sectioned Nissl-stained material are 0.32 ± 0.03 mm3 with correction for shrinkage.
“For example, delineations of the dorsal lateral geniculate nucleus (LGD) of AD-BXD F1s have mean unilateral volumes of approximately 0.35 ± 0.04 SD mm3, whereas our previous estimates of adult B6D2F1 hybrid from celloidin-sectioned Nissl-stained material are 0.32 ± 0.03 mm3 with correction for shrinkage94.”
From Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice (2026) · cites this paper as [94]
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Self-citationMiller, A. K., Bartlett, J., Pan, C., Lusis, A. J., Crawford, D. C., Williams, S. M., & Buchner, D. A. (2025) · Nature Communications · doi:10.1038/s41467-025-63763-x · Cited by 1 · see citing works
Experimental precision medicine: Mouse models to test precision medicine
Ashbrook, D. G. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824010-6.00057-5
Johnson, G. A., Tian, Y., Hornburg, K. J., Cook, J. J., Qi, Y. P., WHITE, L. E., KILLMAR, J. T., Kaczorowski, C. C., Ashbrook, D. G., & Williams, R. W. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.08.632011
Self-citationCorrelated activity and corticothalamic cell function in the early mouse visual system
Denman, D. J. (2014) · ScholarlyCommons (University of Pennsylvania)
- Authors
- Seecharan, D. J., Kulkarni, A. L., Lu, L., Rosen, G. D., & Williams, R. W.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-12-03
- Volume
- 23
- Issue
- 35
- Pages
- 11178-11188
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6741036
- OpenAlex
- W2136093811
- Cited by
- 43
- References
- 70
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Institutes of Health (1r01ns035485-01)
- National Institute of Mental Health (P20 MH62009, P20MH062009)
- National Institute on Drug Abuse
- National Eye Institute (R01EY019968, R01 EY12991, R01EY012991, P30EY013080)
- National Institute of Neurological Disorders and Stroke (R01 NS35485)
- National Institute of Environmental Health Sciences (R01ES012991)
- National Center for Research Resources (S10 RR-022585)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- dorsal lateral geniculate nucleus, retinal ganglion cells, glial cells, endothelial cells
- MeSH terms
- Age Factors, Animals, Body Weight, Cell Count, Female, Geniculate Bodies, Immunohistochemistry, Male, Mice, Inbred Strains, Neuroglia, Neurons, Optic Nerve, Organ Size, Regression Analysis, Retinal Ganglion Cells, Sex Factors, Species Specificity, Visual Pathways, Reproducibility of Results, Endothelial Cells, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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