Cited by 504Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

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Neuroinflammation in the pathogenesis of Alzheimerâ€™s disease. A rational framework for the search of novel therapeutic approaches

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Morales, Inelia, GuzmÃ¡n-MartÃnez, Leonardo, Cerda-Troncoso, CristÃ³bal, FarÃas, Gonzalo A., Maccioni, Ricardo B.·2014·Frontiers in Cellular Neuroscience

DOI 10.3389/fncel.2014.00112PMC PMC4001039

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Abstract

Alzheimer disease (AD) is the most common cause of dementia in people over 60 years old. The molecular and cellular alterations that trigger this disease are still diffuse, one of the reasons for the delay in finding an effective treatment. In the search for new targets to search for novel therapeutic avenues, clinical studies in patients who used anti-inflammatory drugs indicating a lower incidence of AD have been of value to support the neuroinflammatory hypothesis of the neurodegenerative processes and the role of innate immunity in this disease. Neuroinflammation appears to occur as a consequence of a series of damage signals, including trauma, infection, oxidative agents, redox iron, oligomers of τ and β-amyloid, etc. In this context, our theory of Neuroimmunomodulation focus on the link between neuronal damage and brain inflammatory process, mediated by the progressive activation of astrocytes and microglial cells with the consequent overproduction of proinflammatory agents. Here, we discuss about the role of microglial and astrocytic cells, the principal agents in neuroinflammation process, in the development of neurodegenerative diseases such as AD. In this context, we also evaluated the potential relevance of natural anti-inflammatory components, which include curcumin and the novel Andean Compound, as agents for AD prevention and as a coadjuvant for AD treatments.

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Additional file 4 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
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Additional file 11 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Barber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Figshare · doi:10.6084/m9.figshare.26737980
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Additional file 6 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Barber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Figshare · doi:10.6084/m9.figshare.26737965
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Additional file 10 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Barber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Figshare · doi:10.6084/m9.figshare.26737977
Additional file 8 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Barber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Figshare · doi:10.6084/m9.figshare.26737971
Additional file 5 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Barber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Figshare · doi:10.6084/m9.figshare.26737962
Additional file 1 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Barber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Figshare · doi:10.6084/m9.figshare.26085125
Additional file 9 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Barber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Figshare · doi:10.6084/m9.figshare.26737974
Additional file 1 of Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer’s disease-like neuroinflammation triggered by periodontal disease
Zhao, C., Kuraji, R., Ye, C., Gao, L., Radaic, A., Kamarajan, P., Taketani, Y., & Kapila, Y. L. (2024) · Figshare · doi:10.6084/m9.figshare.26623864
Additional file 2 of Intermittent hypoxia exacerbates anxiety in high-fat diet-induced diabetic mice by inhibiting TREM2-regulated IFNAR1 signaling
Ni, W., Niu, Y., Cao, S., Fan, C., Fan, J., Zhu, L., & Wang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26157564
Additional file 12 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Barber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Figshare · doi:10.6084/m9.figshare.26737983
Additional file 3 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Barber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Figshare · doi:10.6084/m9.figshare.26737956
Additional file 7 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Barber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Figshare · doi:10.6084/m9.figshare.26737968
Additional file 13 of Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Barber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Figshare · doi:10.6084/m9.figshare.26737986
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Authors: Morales, I., GuzmÃ¡n-MartÃnez, L., Cerda-Troncoso, C., FarÃas, G. A., & Maccioni, R. B.
Affiliations: University of Chile (CL)
Corresponding author: Maccioni, Ricardo B.
ORCID: Maccioni, Ricardo B.
Venue: Frontiers in Cellular Neuroscience
Publisher: Frontiers Media SA
Published: 2014-04-22
Volume: 8
Pages: 112-112
ISSN: 1662-5102 (ISSN-L)
DOI: 10.3389/fncel.2014.00112
PMC: PMC4001039
OpenAlex: W2109984042
Cited by: 490
References: 85
Citations by year: 2026: 13 · 2025: 26 · 2024: 43 · 2023: 38 · 2022: 45 · 2021: 40 · 2020: 50 · 2019: 48 · 2018: 45 · 2017: 50 · 2016: 25 · 2015: 50 · 2014: 14
FWCI: 3.75
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Americanae (AECID Library) (publishedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Universidad de Chile (submittedVersion, cc-by-nc-nd)
Funders: Corporación de Fomento de la Producción
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: Alzheimer's disease, neuroinflammation, neuroimmunomodulation, microglia, astrocytes, innate immunity, anti-inflammatory agents, tau oligomers, amyloid-beta, oxidative stress, iron, curcumin, neurodegeneration, therapeutic target

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Neuroinflammation in the pathogenesis of Alzheimerâ€™s disease. A rational framework for the search of novel therapeutic approaches

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