The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches
Open accessAbstract
Alzheimer disease (AD) is the most common cause of dementia in people over 60 years old. The molecular and cellular alterations that trigger this disease are still diffuse, one of the reasons for the delay in finding an effective treatment. In the search for new targets to search for novel therapeutic avenues, clinical studies in patients who used anti-inflammatory drugs indicating a lower incidence of AD have been of value to support the neuroinflammatory hypothesis of the neurodegenerative processes and the role of innate immunity in this disease. Neuroinflammation appears to occur as a consequence of a series of damage signals, including trauma, infection, oxidative agents, redox iron, oligomers of τ and β-amyloid, etc. In this context, our theory of Neuroimmunomodulation focus on the link between neuronal damage and brain inflammatory process, mediated by the progressive activation of astrocytes and microglial cells with the consequent overproduction of proinflammatory agents. Here, we discuss about the role of microglial and astrocytic cells, the principal agents in neuroinflammation process, in the development of neurodegenerative diseases such as AD. In this context, we also evaluated the potential relevance of natural anti-inflammatory components, which include curcumin and the novel Andean Compound, as agents for AD prevention and as a coadjuvant for AD treatments.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“it remains unclear whether microglial activation is a primary triggering mechanism or merely a consequence of protein aggregate accumulation [60]”
From Theranostic Nanoplatforms for Alzheimer's Disease: A Critical Analysis of Conceptual Contradictions (2026) · cites this paper as [60]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In Alzheimer’s disease, neuroinflammation is primarily thought to be a consequence of a series of damage signals including trauma, oxidation, oligomers of Aβ and tau, and more [67].”
From Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients (2024) · cites this paper as [67]
Experimental — accuracy not yet measuredIn the citing paper
“Pro-inflammatory cytokines and chemokines secreted into the immediate neurological environment accelerate neuronal injury and eventually neuron death (Aktas et al., 2007; Heckmann et al., 2018; Morales et al.,2014).”
From LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease (2019) · cites this paper as Morales et al.,2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676
Aggarwal, B. B., & Harikumar, K. B. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.06.010 · Cited by 2,139
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688
Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis
Sierra, A., Encinas, J. M., Deudero, J. J. P., Chancey, J. H., Enikolopov, G., Overstreet-Wadiche, L. S., Tsirka, S. E., & Maletic-Savatic, M. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.014 · Cited by 1,622
Microglia in neurodegenerative disease
Perry, V. H., Nicoll, J. A. R., & Holmes, C. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.17 · Cited by 1,543
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
Weggen, S., Eriksen, J. L., Das, P., Sagi, S. A., Wang, R., Pietrzik, C. U., Findlay, K. A., Smith, T. E., Murphy, M. P., Bulter, T., et al. (2001) · Nature · doi:10.1038/35102591 · Cited by 1,388 · cited 1×
“Even in mice, NSAIDs directly affect the development of amyloid in the brain, reducing Aβ-42 peptide levels (Weggen et al., 2001).”
Background
Flagged first, then by citations
Research works printed but not linked: 1
- Powell, 1999, Dissection of astrocyte-mediated cues in neuronal guidance and process extension, Glia, 26, 73, 10.1002/(sici)1098-1136(199903)26:173::aid-glia83.0.co;2-s · DOI
Cited by
Sorted by citations
Items 101–200 of 504
Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer’s disease
Lee, H., Lee, K.-I., Chen, C.-H., & Lee, T. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1635-9 · Cited by 69
Epigallocatechin-3-gallate Alleviates Cognitive Deficits in APP/PS1 Mice
Bao, J., Liu, W. D., Zhou, H., Gui, Y., Yang, Y., Wu, M., Xiao, Y., Shang, J., Long, G.-F., & Shu, X. (2020) · Current Medical Science · doi:10.1007/s11596-020-2142-z · Cited by 72
Zheng, Y. M., Deng, Y., Gao, J.-M., Lv, C., Lang, L.-H., Shi, J., Yu, C., & Gong, Q. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0300-2 · Cited by 71
Silva, D. F., Candeias, E., Esteves, A. R., Magalhães, J. D., Ferreira, I. L., Nunes‐Costa, D., Rego, A. C., Empadinhas, N., & Cardoso, S. M. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02004-y · Cited by 73
Wendt, S., Maricos, M., Vana, N., Meyer, N., Guneykaya, D., Semtner, M., & Kettenmann, H. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.05.027 · Cited by 69
McCarthy, R. C., Lu, D., Alkhateeb, A. A., Gardeck, A. M., Lee, C., & Wessling‐Resnick, M. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0484-z · Cited by 67
Protective effects of different exercise modalities in an Alzheimer’s disease-like model
Özbeyli, D., Sarı, G., Özkan, N., Karademir-Yilmaz, B., Yüksel, M., Çilingir‐Kaya, Ö. T., & ÇAKIR, Ö. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.03.044 · Cited by 68
Wang, Q., Wang, Y., Liu, J., Sutphen, C. L., Cruchaga, C., Blazey, T., Gordon, B. A., Su, Y., Chen, C., Shimony, J. S., et al. (2019) · NeuroImage: Clinical · doi:10.1016/j.nicl.2019.101767 · Cited by 63
Pharmacotherapy of Alzheimer’s disease: current and future trends
Geldenhuys, W. J., & Darvesh, A. S. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.990884 · Cited by 66
Li, S., Dong, C., Geng, D., He, Q., & Shi, Y. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.07.081 · Cited by 67
Cao, L., Cao, X., Zhou, Y., Nagpure, B. V., Wu, Z., Hu, L. F., Yang, Y., Sethi, G., Moore, P. K., & Bian, J. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.005 · Cited by 64
Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer’s Disease
Janota, C. S., Lemere, C. A., & Brito, M. A. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9319-7 · Cited by 70
Obesity and Diabetes Mediated Chronic Inflammation: A Potential Biomarker in Alzheimer’s Disease
Khan, M. S. H., & Hegde, V. K. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10020042 · Cited by 71
The Role of Interleukin-18, Oxidative Stress and Metabolic Syndrome in Alzheimer’s Disease
Ojala, J. O., & Sutinen, E. M. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6050055 · Cited by 64
Exosomes: a novel therapeutic target for Alzheimer’s disease?
Cai, Z., Ke, Z.-Y., Xiao, M., & Quazi, S. H. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.232490 · Cited by 64
Immunomodulatory role of mesenchymal stem cells in Alzheimer's disease
Zhang, L., Dong, Z., & Zhang, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117405 · Cited by 63
Staurenghi, E., Cerrato, V., Gamba, P., Testa, G., Giannelli, S., Leoni, V., Caccia, C., Buffo, A., Noble, W., Perez-Nievas, B. G., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2020.101837 · Cited by 60
Sources and triggers of oxidative damage in neurodegeneration
Angelova, P. R. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.07.003 · Cited by 67
Mapping neuroinflammation in frontotemporal dementia with molecular PET imaging
Zhang, J. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0236-5 · Cited by 62
Dubey, S. K., Munnangi, S. R., Krishna, K. V., Saha, R. N., Singhvi, G., Agrawal, M., Ajazuddin, M., Saraf, S., Saraf, S., & Alexander, A. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00653-z · Cited by 64
Kim, Y., Lim, J., & Oh, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117277 · Cited by 67
Role of Toll-like receptor/MYD88 signaling in neurodegenerative diseases
Xiang, W., Chao, Z.-Y., & Feng, D.-Y. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0067 · Cited by 62
Verma, V., Singh, D., & Reeta, K. H. (2020) · Brain Sciences · doi:10.3390/brainsci10120923 · Cited by 62
Tong, X., & Hamel, É. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.226 · Cited by 61
Shah, T. M., Gupta, S. M., Chatterjee, P., Campbell, M., & Martins, R. N. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.251 · Cited by 62
Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease
O’Callaghan, J. M., Holmes, H. E., Powell, N. M., Wells, J. A., Ismail, O., Harrison, I. F., Siow, B. M., Johnson, R. A., Ahmed, Z., Fisher, A., et al. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.08.003 · Cited by 63
Hambali, A., Kumar, J., Hashim, N. F. M., Maniam, S., Mehat, M. Z., Cheema, M. S., Mustapha, M., Adenan, M. I., Stanslas, J., & Hamid, H. A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.712317 · Cited by 65
Sleep and circadian rhythm disruption and stress intersect in Alzheimer's disease
Phan, T., & Malkani, R. G. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.10.001 · Cited by 66
Ko, S. Y., Lee, H. E., Park, S. J., Jeon, S. J., Kim, B., Gao, Q., Jang, D. S., & Ryu, J. H. (2015) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2014.110 · Cited by 60
Alzheimer´s Disease in the Perspective of Neuroimmunology
Maccioni, R. B., González, A., Andrade, V., Cortés, N., Tapia, J. P., & Guzmán‐Martínez, L. (2018) · The Open Neurology Journal · doi:10.2174/1874205x01812010050 · Cited by 58
Self-citationAhmad, M. H., Fatima, M., & Mondal, A. C. (2019) · Neuropsychobiology · doi:10.1159/000495521 · Cited by 61
Saputra, W. D., Aoyama, N., Komai, M., & Shirakawa, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092317 · Cited by 58
Zhu, C., Xu, B., Sun, X., Zhu, Q., & Sui, Y. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0269-5 · Cited by 59
Beta-carotene, telomerase activity and Alzheimer’s disease in old age subjects
Boccardi, V., Arosio, B., Cari, L., Bastiani, P., Scamosci, M., Casati, M., Ferri, E., Bertagnoli, L., Ciccone, S., Rossi, P. D., et al. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-01892-y · Cited by 58
Exercise mimetics: a novel strategy to combat neuroinflammation and Alzheimer’s disease
Zhao, R. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03031-9 · Cited by 64
Alzheimer’s disease and gut microbiota: does trimethylamine N-oxide (TMAO) play a role?
Arrona Cardoza, P., Spillane, M. B., & Morales Marroquin, E. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuab022 · Cited by 53
Neuroinflammation in the Cerebellum and Brainstem in Friedreich Ataxia: An [ 18F ]‐ FEMPA PET Study
Khan, W., Corben, L. A., Bilal, H., Vivash, L. E., Delatycki, M. B., Egan, G. F., & Harding, I. H. (2021) · Movement Disorders · doi:10.1002/mds.28825 · Cited by 54
Ruganzu, J. B., Peng, X., He, Y., Wu, X., Zheng, Q., Ding, B., Lin, C., Guo, H., Yang, Z., Zhang, X. L., et al. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.12.018 · Cited by 56
Tran, D. Q., Tse, E. K., Kim, M. H., & Belsham, D. D. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.05.015 · Cited by 55
PET Imaging for Early Detection of Alzheimer’s Disease
Bao, W., Jia, H., Finnema, S. J., Cai, Z., Carson, R. E., & Huang, Y. H. (2017) · PET Clinics · doi:10.1016/j.cpet.2017.03.001 · Cited by 54
Kynurenine Metabolism and Alzheimer’s Disease: The Potential Targets and Approaches
Sharma, V., Singh, T. G., Prabhakar, N. K., & Mannan, A. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03546-8 · Cited by 52
Clinical and Preclinical Studies of Fermented Foods and Their Effects on Alzheimer’s Disease
Kumar, M. R., Azizi, N. F., Yeap, S. K., Abdullah, J. O., Khalid, M., Omar, A. R., Osman, M. A., Leow, T. C., Mortadza, S. A. S., & Alitheen, N. B. (2022) · Antioxidants · doi:10.3390/antiox11050883 · Cited by 60
Cutuli, D., Decandia, D., Giacovazzo, G., & Coccurello, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914686 · Cited by 61
Zhang, Y., Hu, W., Zhang, B., Yin, Y., Zhang, J., Huang, D., Huang, R., Li, W., & Li, W. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3092 · Cited by 53
Hao, R., Song, X., Li, F., Tan, X., Sun‐Waterhouse, D., & Li, D. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111636 · Cited by 55
Bi, D., Lai, Q., Cai, N., Li, T., Zhang, Y., Han, Q., Peng, Y., Xu, H. Y., Lu, J., Bao, W.-Y., et al. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b05719 · Cited by 52
Extracellular cardiolipin regulates select immune functions of microglia and microglia-like cells
Pointer, C. B., Wenzel, T. J., & Klegeris, A. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.01.002 · Cited by 53
Acquired Resilience: An Evolved System of Tissue Protection in Mammals
Stone, J., Mitrofanis, J., Johnstone, D. M., Falsini, B., Bisti, S., Adam, P., Bravo‐Nuevo, A., George‐Weinstein, M., Mason, R. S., & Eells, J. T. (2018) · Dose-Response · doi:10.1177/1559325818803428 · Cited by 51
The Natural Product Curcumin as a Potential Coadjuvant in Alzheimer's Treatment
Morales, I., Cerda-Troncoso, C., Andrade, V., & Maccioni, R. B. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170354 · Cited by 51
Singh, S., Sahu, K., Kapil, L., Singh, C., & Singh, A. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07161-2 · Cited by 54
Curcumin: A multi-target disease-modifying agent for late-stage transthyretin amyloidosis
Ferreira, N., Gonçalves, N. P., Saraiva, M. J., & Almeida, M. R. (2016) · Scientific Reports · doi:10.1038/srep26623 · Cited by 55
Lim, H.-S., Kim, O. S., Kim, B., & Jeong, S. (2016) · Journal of Medicinal Food · doi:10.1089/jmf.2016.0074 · Cited by 50
Chen, K., Chen, Y., Fan, Y., Lin, W., Lin, W., Wang, Y., Lin, L., Chiou, J., & Wei, J. C. (2017) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.13246 · Cited by 49
Lipopolysaccharide Induced Opening of the Blood Brain Barrier on Aging 5XFAD Mouse Model
Barton, S. M., Janve, V. A., McClure, R., Anderson, A. W., Matsubara, J. A., Gore, J. C., & Pham, W. N. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180755 · Cited by 49
Wojtunik‐Kulesza, K. A., Rudkowska, M., Kasprzak‐Drozd, K., Oniszczuk, A., & Borowicz, K. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147366 · Cited by 51
Angeloni, S., Freschi, M., Marrazzo, P., Hrelia, S., Beghelli, D., Juan-García, A., Juan, C., Caprioli, G., Sagratini, G., & Angeloni, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6620913 · Cited by 50
Behavioral and neuropsychiatric disorders in Alzheimer's disease
Cortés, N., Andrade, V., & Maccioni, R. B. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-180005 · Cited by 57
Self-citationChen, L., van Zijl, P. C. M., Wei, Z., Lu, H., Duan, W., Wong, P. C., Li, T., & Xu, J. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118071 · Cited by 48
Chen, M., Chang, Y., Huang, S., Xiao, L., Zhou, W., Zhang, L., Li, C., Zhou, R., Tang, J., Lin, L., et al. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700281 · Cited by 47
Troxerutin protects hippocampal neurons against amyloid beta-induced oxidative stress and apoptosis
Farajdokht, F., Amani, M., Mirzaei, F., Alihemmati, A., Mohaddes, G., & Babri, S. (2017) · EXCLI journal · doi:10.17179/excli2017-526 · Cited by 48
Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease
Reich, N., & Hölscher, C. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.614828 · Cited by 48
“Furthermore, pathogen-associated molecular patterns (PAMPs) that originate from cerebral infections, such as LPS, or, in the case of AD, infections with members of the Herpesviridae family and Hepatitis C virus, may further potentiate neuroinflammation (Morales et al., 2014; Sochocka et al., 2017; Cortes et al., 2018;…”
BackgroundAccelerating Alzheimerʼs research through ‘natural’ animal models
Braidy, N., Poljak, A., Jayasena, T., Mansour, H., Inestrosa, N. C., & Sachdev, P. S. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000137 · Cited by 50
Xia, W., Luo, P., Hua, P., Ding, P., Li, C., Xu, J., Zhou, H., & Gu, Q. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00243 · Cited by 46
Dementia spectrum disorders: lessons learnt from decades with PET research
Wilson, H., Pagano, G., & Politis, M. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-01975-4 · Cited by 50
Zhou, Y., Yan, Y., Li, S., He, D., Xiong, S., Wei, S.-F., Liu, W., Hu, L., Wang, Q., Pan, H., et al. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0261-5 · Cited by 47
Xian, Y., Qu, C. F., Liu, Y., Ip, S., Yuan, Q., Yang, W., & Lin, Z. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5920476 · Cited by 48
He, Y., Ruganzu, J. B., Jin, H., Peng, X., Ji, S., Ma, Y., Zheng, L., & Yang, W. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112166 · Cited by 46
He, Y., Ruganzu, J. B., Zheng, Q., Wu, X., Jin, H., Peng, X., Ding, B., Lin, C., Ji, S., Ma, Y., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01982-7 · Cited by 47
The Role of Smurf1 in Neuronal Necroptosis after Lipopolysaccharide-Induced Neuroinflammation
Shao, L., Liu, X., Zhu, S., Liu, C., Gao, Y., & Xu, X. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0553-6 · Cited by 46
Molecular Mechanisms of Curcumin in Neuroinflammatory Disorders: A Mini Review of Current Evidences
Hatami, M., Abdolahi, M., Soveyd, N., Djalali, M., Togha, M., & Honarvar, N. M. (2018) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530319666181129103056 · Cited by 46
Deciphering the Function and Regulation of microRNAs in Alzheimer’s Disease and Parkinson’s Disease
Qiu, L., Zhang, W., Tan, E., & Zeng, L. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500149w · Cited by 45
Neuroinflammation in hypertension: the renin-angiotensin system versus pro-resolution pathways
Mowry, F. E., & Biancardi, V. C. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.04.029 · Cited by 45
Monoclonal Antibody Therapy in Alzheimer’s Disease
Neațu, M., Covaliu, A., Ioniță, I., Jugurt, A., Davidescu, E. I., & Popescu, B. O. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics16010060 · Cited by 46
Kumar, A., Ekavali, Mishra, J., Chopra, K., & Dhull, D. K. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4095-7 · Cited by 44
Neuroimmune Tau Mechanisms: Their Role in the Progression of Neuronal Degeneration
Cortés, N., Andrade, V., Guzmán‐Martínez, L., Estrella, M., & Maccioni, R. B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19040956 · Cited by 43
Self-citationGuanosine monophosphate reductase 1 is a potential therapeutic target for Alzheimer’s disease
Liu, H., Luo, K., & Luo, D. (2018) · Scientific Reports · doi:10.1038/s41598-018-21256-6 · Cited by 42
Reich, N., & Hölscher, C. (2024) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2024.101122 · Cited by 43
Biomarkers for Alzheimer's disease
Pauwels, E. K. J., Volterani, D., & Marlani, G. (2009) · Drug News & Perspectives · doi:10.1358/dnp.2009.22.3.1354128 · Cited by 44
Huang, C., Dong, D., Jiao, Q., Pan, H., Ma, L., & Wang, R. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12697 · Cited by 43
Barber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Alzheimer's Research & Therapy · doi:10.1186/s13195-024-01492-x · Cited by 41
Sun, Y., Chauhan, A., Sukumaran, P., Sharma, J., Singh, B. B., & Mishra, B. B. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0210-7 · Cited by 43
Inflammation: A Major Target for Compounds to Control Alzheimer’s Disease
Maccioni, R. B., Navarrete, L. P., González, A., González-Canacer, A., Guzmán‐Martínez, L., & Cortés, N. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191014 · Cited by 42
Self-citationMusumeci, T., Benedetto, G. D., Carbone, C., Bonaccorso, A., Amato, G., Faro, M. J. L., Burgaletto, C., Puglisi, G., Bernardini, R., & Cantarella, G. (2022) · Biomedicines · doi:10.3390/biomedicines10050985 · Cited by 41
Afsar, A., Castro, M. D. C. C., Soladogun, A. S., & Li, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087258 · Cited by 45
Zhao, C., Kuraji, R., Ye, C., Gao, L., Radaic, A., Kamarajan, P., Taketani, Y., & Kapila, Y. L. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02915-6 · Cited by 45
de la Torre, C., & Ceña, V. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10040190 · Cited by 42
Yang, G., Song, Y., Zhou, X., Deng, Y., Liu, T., Weng, G., Yu, D., & Pan, S. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3531 · Cited by 39
Kai-Xin-San Inhibits Tau Pathology and Neuronal Apoptosis in Aged SAMP8 Mice
Jiao, Y.-N., Zhang, J., Wen-jun, Q., Tian, S.-Y., Wang, Y.-B., Wang, C., Zhang, Y., Zhang, Q., Li, W., Min, D., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02626-0 · Cited by 41
Neurotransmitters in Type 2 Diabetes and the Control of Systemic and Central Energy Balance
Al-Sayyar, A., Hammad, M. M., Williams, M. R., Al‐Onaizi, M., Abubaker, J. A., & Alzaïd, F. (2023) · Metabolites · doi:10.3390/metabo13030384 · Cited by 45
Raha, S., Lee, H. J., Yumnam, S., Hong, G. E., Saralamma, V. V. G., Ha, Y. L., Kim, J. O., Kim, Y. S., Heo, J., Lee, S. J., et al. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.07.017 · Cited by 39
Tom, S., Rane, A., Katewa, A., Chamoli, M., Matsumoto, R. R., Andersen, J. K., & Chinta, S. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1636-9 · Cited by 39
Talebi, M., Kakouri, E., Talebi, M., Tarantilis, P. Α., Farkhondeh, T., İlgün, S., Pourbagher‐Shahri, A. M., & Samarghandian, S. (2021) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2021.1923479 · Cited by 41
Amyloid burden accelerates white matter degradation in cognitively normal elderly individuals
Vipin, A., Ng, K. K., Ji, F., Shim, H. Y., Lim, J. K. W., Pasternak, O., Zhou, J. H., & Initiative, A. D. N. (2019) · Human Brain Mapping · doi:10.1002/hbm.24507 · Cited by 37
Yang, X., Zhi, J., Leng, H., Chen, Y., Gao, H., Ma, J., Ji, J., & Hu, Q. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153571 · Cited by 40
Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses
Alves, S. S., da Silva-Júnior, R. M. P., Servilha‐Menezes, G., Homolak, J., Šalković‐Petrišić, M., & Garcia‐Cairasco, N. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210234 · Cited by 39
Wu, J., Zhu, Y., Zhou, L., Yang, L., Feng, T., Dai, M., Liu, J., Xu, W., Cheng, W., Sun, F., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.710513 · Cited by 36
Esteves, A. R., Silva, D. F., Banha, D., Candeias, E., Guedes, B., & Cardoso, S. M. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102714 · Cited by 38
Adiponectin and sporadic Alzheimer’s disease: Clinical and molecular links
Letra, L., Rodrigues, T., Matafome, P. N., Santana, I. J., & Seiça, R. M. F. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.002 · Cited by 38
Chuang, K., Li, M., Lin, N., Chang, C.-H., Lu, I.-H., Pan, I.-H., Takahashi, T., Perng, M., & Wen, S. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5414297 · Cited by 40
Current druggable targets for therapeutic control of Alzheimer's disease
Gupta, G. L., & Samant, N. P. (2021) · Contemporary Clinical Trials · doi:10.1016/j.cct.2021.106549 · Cited by 38
Metadata
- Authors
- Morales, I., Guzmán-MartÃnez, L., Cerda-Troncoso, C., FarÃas, G. A., & Maccioni, R. B.
- Affiliations
- University of Chile (CL)
- Corresponding author
- Maccioni, Ricardo B.
- ORCID
- Maccioni, Ricardo B.
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-04-22
- Volume
- 8
- Pages
- 112-112
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4001039
- OpenAlex
- W2109984042
- Cited by
- 490
- References
- 85
- Citations by year
- 2026: 13 · 2025: 26 · 2024: 43 · 2023: 38 · 2022: 45 · 2021: 40 · 2020: 50 · 2019: 48 · 2018: 45 · 2017: 50 · 2016: 25 · 2015: 50 · 2014: 14
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Funders
- Corporación de Fomento de la Producción
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, neuroinflammation, neuroimmunomodulation, microglia, astrocytes, innate immunity, anti-inflammatory agents, tau oligomers, amyloid-beta, oxidative stress, iron, curcumin, neurodegeneration, therapeutic target
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
