Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives

Early developmental alterations in GABAergic protein expression in fragile X knockout mice

Adusei, D. C., Pacey, L. K. K., Chen, D., & Hampson, D. R. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.05.002 · Cited by 139

A novel mechanism for GABA synthesis and packaging into synaptic vesicles

Buddhala, C., Hsu, C., & Wu, J. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.01.020 · Cited by 138

Molecular regulation of cognitive functions and developmental plasticity: impact of GABAAreceptors

Möhler, H. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04454.x · Cited by 138

Development of cortical GABAergic circuits and its implications for neurodevelopmental disorders

Cristo, G. D. (2007) · Clinical Genetics · doi:10.1111/j.1399-0004.2007.00822.x · Cited by 138

GABAergic control of neurite outgrowth and remodeling during development and adult neurogenesis: general rules and differences in diverse systems

Sernagor, E. (2010) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2010.00011 · Cited by 137

Gamma‐aminobutyric acid uptake and the termination of inhibitory synaptic potentials in the rat hippocampal slice.

Dingledine, R. J., & Korn, S. J. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015804 · Cited by 137

Phospholipase C-β1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration

Mcomish, C., Burrows, E., Howard, M., Scarr, E., Kim, D., Shin, H.-S., Dean, B., van den Buuse, M., & Hannan, A. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002046 · Cited by 136

Interaction of Calcineurin and Type-A GABA Receptor γ2Subunits Produces Long-Term Depression at CA1 Inhibitory Synapses

Wang, J., Liu, S., Haditsch, U., Tu, W., Cochrane, K., Ahmadian, G., Tran, L., Paw, J., Wang, Y., Mansuy, I. M., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00826.2003 · Cited by 134

The GABAA Receptor Agonist THIP Ameliorates Specific Behavioral Deficits in the Mouse Model of Fragile X Syndrome

Olmos-Serrano, J. L., Corbin, J. G., & Burns, M. P. (2011) · Developmental Neuroscience · doi:10.1159/000332884 · Cited by 134

Activity-Dependent Ubiquitination of GABAAReceptors Regulates Their Accumulation at Synaptic Sites

Saliba, R. S., Michels, G., Jacob, T. C., Pangalos, M. N., & Moss, S. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3277-07.2007 · Cited by 133

Decreased Seizure Activity in a Human Neonate Treated With Bumetanide, an Inhibitor of the Na + -K + -2Cl - Cotransporter NKCC1

Kahle, K. T., Barnett, S. M., Sassower, K., & Staley, K. J. (2009) · Journal of Child Neurology · doi:10.1177/0883073809333526 · Cited by 131

The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures

Kahle, K. T., & Staley, K. J. (2008) · Neurosurgical FOCUS · doi:10.3171/foc/2008/25/9/e22 · Cited by 131

Multiple roles of protein kinases in the modulation of γ-aminobutyric acidA receptor function and cell surface expression

Brandon, N. J., Jovanovic, J. N., & Moss, S. J. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00175-4 · Cited by 131

Improving emotional face perception in autism with diuretic bumetanide: A proof-of-concept behavioral and functional brain imaging pilot study

Hadjikhani, N., Zürcher, N. R., Rogier, O., Ruest, T., Hippolyte, L., Ben-Ari, Y., & Lemonnier, E. (2015) · Autism · doi:10.1177/1362361313514141 · Cited by 129

Altered Expression of Regulators of the Cortical Chloride Transporters NKCC1 and KCC2 in Schizophrenia

Arion, D., & Lewis, D. A. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.114 · Cited by 129

Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABA A receptor γ2 subunit

Kittler, J. T., Chen, G., Kukhtina, V., Vahedi‐Faridi, A., Gu, Z., Tretter, V. E., Smith, K. R., McAinsh, K., Arancibia‐Cárcamo, I. L., Saenger, W., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707920105 · Cited by 129

The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: A pilot [11C]Ro15-4513 positron emission tomography study

Méndez, M. A., Horder, J., Myers, J., Coghlan, S., Stokes, P. R. A., Erritzøe, D., Howes, O. D., Lingford-Hughes, A. R., Murphy, D., & Nutt, D. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.04.008 · Cited by 128

Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome

Rueda, N., Flórez, J., & Martínez‐Cué, C. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2007.12.039 · Cited by 127

Newborn Analgesia Mediated by Oxytocin during Delivery

Mazzuca, M., Minlebaev, M., Shakirzyanova, A., Tyzio, R., Taccola, G., Janáčková, S., Gataullina, S., Ben‐Ari, Y., Giniatullin, R. A., & Khazipov, R. (2011) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2011.00003 · Cited by 127

Fetal Down Syndrome Brains Exhibit Aberrant Levels of Neurotransmitters Critical for Normal Brain Development

Whittle, N., Sartori, S. B., Dierssen, M., Lubec, G., & Singewald, N. (2007) · Pediatrics · doi:10.1542/peds.2006-3448 · Cited by 127

Kinetic differences between the isoforms of glutamate decarboxylase: implications for the regulation of GABA synthesis

Battaglioli, G., Liu, H., & Martin, D. L. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01910.x · Cited by 126

Efferent connections of the caudal part of the globus pallidus in the rat

Shammah‐Lagnado, S. J., Alheid, G. F., & Heimer, L. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961216)376:3 · Cited by 126

Altered Development of Glutamate and GABA Receptors in the Basal Ganglia of Girls with Rett Syndrome

Blue, M. E., Naidu, S., & Johnston, M. V. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7030 · Cited by 126

Variation in memory and the hippocampus across populations from different climates: a common garden approach

Roth, T. C., LaDage, L. D., Freas, C. A., & Витальевич, П. В. (2011) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2011.1020 · Cited by 126

Pharmacological treatment of fragile X syndrome with GABAergic drugs in a knockout mouse model

Heulens, I., D’Hulst, C., Dam, D. V., Deyn, P. P. D., & Kooy, R. F. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.01.031 · Cited by 125

Loss of MeCP2 From Forebrain Excitatory Neurons Leads to Cortical Hyperexcitation and Seizures

Zhang, W., Peterson, M., Beyer, B., Frankel, W. N., & Zhang, Z.-W. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4900-12.2014 · Cited by 125

Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome

Kleschevnikov, A. M., Belichenko, P. V., Gall, J., George, L., Nosheny, R., Maloney, M. T., Salehi, A., & Mobley, W. C. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.10.009 · Cited by 124

Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis

Duveau, V., Laustela, S., Barth, L., Gianolini, F., Vogt, K. E., Keist, R., Chandra, D., Homanics, G. E., Rudolph, U., & Fritschy, J. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07782.x · Cited by 124

GABAergic inhibition in visual cortical plasticity

Sale, A. (2010) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2010.00010 · Cited by 122

Expression Pattern of the Rett Syndrome Gene MeCP2 in Primate Prefrontal Cortex

Akbarian, S., Chen, R. Z., Gribnau, J. H., Rasmussen, T. P., Fong, H., Jaenisch, R., & Jones, E. G. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0420 · Cited by 121

Lamina-Specific Alterations in Cortical GABAA Receptor Subunit Expression in Schizophrenia

Beneyto, M., Abbott, A., Hashimoto, T., & Lewis, D. A. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq169 · Cited by 121

Aspects of respiration in Planorbis corneus L. and Lymnaea stagnalis L. (gastropoda: pulmonata)

Jones, J. (1961) · Comparative Biochemistry and Physiology · doi:10.1016/0010-406x(61)90042-1 · Cited by 120

Autism spectrum disorders: The quest for genetic syndromes

Zafeiriou, D., Ververi, A., Dafoulis, V., Kalyva, E., & Vargìami, E. (2013) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32152 · Cited by 116

Gamma-aminobutyric acid and somatostatin immunoreactivity in the visual cortex of normal and dark-reared rats

Benevento, L. A., Bakkum, B. W., & Cohen, R. S. (1995) · Brain Research · doi:10.1016/0006-8993(95)00553-3 · Cited by 116

Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy

Eftekhari, S., Habibabadi, J. M., Ziarani, M. N., Fesharaki, S. S. H., Gharakhani, M., Mostafavi, H., Joghataei, M. T., Beladimoghadam, N., Rahimian, E., & Hadjighassem, M. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03654.x · Cited by 114

Furosemide and Mannitol Suppression of Epileptic Activity in the Human Brain

Haglund, M. M., & Hochman, D. W. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00944.2004 · Cited by 113

Enlarged Brain Ventricles and Impaired Neurogenesis in the Ts1Cje and Ts2Cje Mouse Models of Down Syndrome

Ishihara, K., Amano, K., Takaki, E., Shimohata, A., Sago, H., Epstein, C. J., & Yamakawa, K. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp176 · Cited by 113

Motor tics evoked by striatal disinhibition in the rat

Bronfeld, M., Yael, D., Belelovsky, K., & Bar‐Gad, I. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00050 · Cited by 111

The rise of a new GABA pharmacology

Möhler, H. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.10.020 · Cited by 111

The management of tics

Shprecher, D., & Kurlan, R. (2008) · Movement Disorders · doi:10.1002/mds.22378 · Cited by 110

A novel prodrug‐based strategy to increase effects of bumetanide in epilepsy

Töllner, K., Brandt, C., Töpfer, M., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24124 · Cited by 109

Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology

Seidl, R., Cairns, N. J., Singewald, N., Kaehler, S. T., & Lübec, G. (2001) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000346 · Cited by 109

Evidence for an extended duration of GABA‐mediated excitation in the developing male versus female hippocampus

Nuñez, J. L., & McCarthy, M. M. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20567 · Cited by 108

Prominent Expression of Two Forms of Glutamate Decarboxylase in the Embryonic and Early Postnatal Rat Hippocampal Formation

Dupuy, S. T., & Houser, C. R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-21-06919.1996 · Cited by 107

Impaired inhibitory control of cortical synchronization in fragile X syndrome

Paluszkiewicz, S. M., Olmos-Serrano, J. L., Corbin, J. G., & Huntsman, M. M. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00421.2011 · Cited by 107

Transcript-Specific Associations of SLC12A5 (KCC2) in Human Prefrontal Cortex with Development, Schizophrenia, and Affective Disorders

Tao, R., Li, C., Newburn, E. N., Ye, T., Lipska, B. K., Herman, M. M., Weinberger, D. R., Kleinman, J. E., & Hyde, T. M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4626-11.2012 · Cited by 106

Rat and Human Hippocampal α5 Subunit-Containing γ-Aminobutyric AcidA Receptors Have α5β3γ2 Pharmaco logical Characteristics

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Gene expression in dopamine and GABA systems in an animal model of schizophrenia: effects of antipsychotic drugs

Lipska, B. K., Lerman, D. N., Khaing, Z. Z., Weickert, C. S., & Weinberger, D. R. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02738.x · Cited by 104

Predictors of seizure onset in Rett syndrome

Jian, L., Nagarajan, L., de Klerk, N. H., Ravine, D., Bower, C. I., Anderson, A., Williamson, S. L., Christodoulou, J., & Leonard, H. (2006) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2006.06.015 · Cited by 104

Regulation of Excitability by Extrasynaptic GABAA Receptors

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GABAAReceptor Phospho-Dependent Modulation Is Regulated by Phospholipase C-Related Inactive Protein Type 1, a Novel Protein Phosphatase 1 Anchoring Protein

Terunuma, M., Jang, I.-S., Ha, S. H., Kittler, J. T., Kanematsu, T., Jovanovic, J. N., Nakayama, K. I., Akaike, N., Ryu, S. H., Moss, S. J., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1323-04.2004 · Cited by 103

Large long-lasting potentiation in the dentate gyrus in vitro during blockade of inhibition

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Altered GABA Signaling in Early Life Epilepsies

Briggs, S. W., & Galanopoulou, A. S. (2011) · Neural Plasticity · doi:10.1155/2011/527605 · Cited by 102

Activity‐dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current

Saliba, R. S., Kretschmannova, K., & Moss, S. (2012) · EMBO Journal · doi:10.1038/emboj.2012.109 · Cited by 102

Clinical and EEG response to anticonvulsants in neonatal seizures.

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Functional role of ambient GABA in refining neuronal circuits early in postnatal development

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Epilepsy in individuals with neurofibromatosis type 1

Ostendorf, A. P., Gutmann, D. H., & Weisenberg, J. L. Z. (2013) · Epilepsia · doi:10.1111/epi.12348 · Cited by 99

Protein Kinase C Phosphorylation Regulates Membrane Insertion of GABAA Receptor Subtypes That Mediate Tonic Inhibition

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Modeling cognitive dysfunction in neurofibromatosis-1

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Environmental enrichment alters locomotor behaviour and ventricular volume in Mecp21lox mice

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Paradoxical reactions elicited by diazepam in children with classic autism.

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Circadian Modulation of GABA Function in the Rat Suprachiasmatic Nucleus: Excitatory Effects During the Night Phase

de Jeu, M. T. G., & Pennartz, C. M. A. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00241.2001 · Cited by 95

Abnormal Expression of Cerebrospinal Fluid Cation Chloride Cotransporters in Patients with Rett Syndrome

Duarte, S. T., Armstrong, J., Roche, A., Ortez, C., Pérez, A., O’Callaghan, M. D. M., Pereira, A., Sanmartí, F., Ormazábal, A., Artuch, R., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068851 · Cited by 94

The DLX1and DLX2 genes and susceptibility to autism spectrum disorders

Liu, X., Novosedlik, N., Wang, A., Hudson, M. L., Cohen, I. L., Chudley, A. E., Forster‐Gibson, C., Lewis, M. E. S., & Holden, J. J. A. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.148 · Cited by 94

mRNA and protein expression for novel GABAA receptors θ and ρ2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway

Fatemi, S. H., Folsom, T. D., Rooney, R. J., & THURAS, P. D. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.46 · Cited by 94

Neonatal seizures

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Intracellular chloride concentration influences the GABAA receptor subunit composition

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Psychological disturbance and sleep disorders in children with neurofibromatosis type 1

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Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for down’s syndrome.

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Dopaminergic regulation of glutamic acid decarboxylase mRNA expression and GABA release in the striatum: A review

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Antiepileptic drugs: affective use in autism spectrum disorders

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Epilepsy in patients with Angelman syndrome

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Evaluation of the GABAergic nervous system in autistic brain: 123I-iomazenil SPECT study

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Reduction of brain gamma-aminobutyric acid (GABA) concentrations in early-stage schizophrenia patients: 3T Proton MRS study.

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Prospects for Improving Brain Function in Individuals with Down Syndrome

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Seizures accelerate anoxia-induced neuronal death in the neonatal rat hippocampus

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Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome

Begenisic, T., Spolidoro, M., Braschi, C., Baroncelli, L., Milanese, M., Pietra, G., Fabbri, M. E., Bonanno, G., Cioni, G., Maffei, L., et al. (2011) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2011.00029 · Cited by 81

MeCP2 Is Required for Normal Development of GABAergic Circuits in the Thalamus

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A Critical Period in Cortical Interneuron Neurogenesis in Down Syndrome Revealed by Human Neural Progenitor Cells

Bhattacharyya, A., McMillan, E., Chen, S. I., Wallace, K., & Svendsen, C. N. (2009) · Developmental Neuroscience · doi:10.1159/000236899 · Cited by 79

Review Article : Molecular and Cellular Mechanisms Underlying the Cognitive Deficits Associated With Neurofibromatosis 1

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NKCC1 Knockdown Decreases Neuron Production through GABAA-Regulated Neural Progenitor Proliferation and Delays Dendrite Development

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Mode of delivery modulates physiological and behavioral responses to neonatal pain

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GABA deficit in the visual cortex of patients with neurofibromatosis type 1: genotype–phenotype correlations and functional impact

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Early Enriched Environment Promotes Neonatal GABAergic Neurotransmission and Accelerates Synapse Maturation

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GABAA increases calcium in subventricular zone astrocyte-like cells through L- and T-type voltage-gated calcium channels

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Basal versus apical dendritic long-term potentiation of commissural afferents to hippocampal CA1: a current-source density study

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[3H]-Flunitrazepam-labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study

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GAT1 and GAT3 expression are differently localized in the human epileptogenic hippocampus

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Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down Syndrome

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Effects of Environmental Enrichment on Repetitive Behaviors in the BTBR T+tf/J Mouse Model of Autism

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Phosphorylation of Serine Residues 3, 6, 10, and 13 Distinguishes Membrane Anchored from Soluble Glutamic Acid Decarboxylase 65 and Is Restricted to Glutamic Acid Decarboxylase 65α

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Characteristics of the Cation Cotransporter NKCC1 in Human Brain: Alternate Transcripts, Expression in Development, and Potential Relationships to Brain Function and Schizophrenia

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Blockade of GABAA Receptors Facilitates Induction of NMDA Receptor-Independent Long-Term Potentiation

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Unconventional Transcriptional Response to Environmental Enrichment in a Mouse Model of Rett Syndrome

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