The DOI matches its Crossref record; 359 of the 359 references it cites were found in a registry or an index.
Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives
Open accessAbstract
During mammalian ontogenesis, the neurotransmitter GABA is a fundamental regulator of neuronal networks. In neuronal development, GABAergic signaling regulates neural proliferation, migration, differentiation, and neuronal-network wiring. In the adult, GABA orchestrates the activity of different neuronal cell-types largely interconnected, by powerfully modulating synaptic activity. GABA exerts these functions by binding to chloride-permeable ionotropic GABAA receptors and metabotropic GABAB receptors. According to its functional importance during development, GABA is implicated in a number of neurodevelopmental disorders such as autism, Fragile X, Rett syndrome, Down syndrome, schizophrenia, Tourette's syndrome and neurofibromatosis. The strength and polarity of GABAergic transmission is continuously modulated during physiological, but also pathological conditions. For GABAergic transmission through GABAA receptors, strength regulation is achieved by different mechanisms such as modulation of GABAA receptors themselves, variation of intracellular chloride concentration, and alteration in GABA metabolism. In the never-ending effort to find possible treatments for GABA-related neurological diseases, of great importance would be modulating GABAergic transmission in a safe and possibly physiological way, without the dangers of either silencing network activity or causing epileptic seizures. In this review, we will discuss the different ways to modulate GABAergic transmission normally at work both during physiological and pathological conditions. Our aim is to highlight new research perspectives for therapeutic treatments that reinstate natural and physiological brain functions in neuro-pathological conditions.
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“Altered DNA methylation has been linked to reduced expression of genes in the GABAergic inhibitory system, a neurotransmitter system implicated in the pathophysiology of ASD [ 156 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [156]
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Early depolarizing GABA controls critical-period plasticity in the rat visual cortex
Deidda, G., Allegra, M., Cerri, C., Naskar, S., Bony, G., Zunino, G., Bozzi, Y., Caleo, M., & Cancedda, L. (2015) · Nature Neuroscience · doi:10.1038/nn.3890 · Cited by 120
Self-citationNeural Hyperexcitability in Autism Spectrum Disorders
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Clostridioides difficile and neurological disorders: new perspectives
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Metadata
- Authors
- Deidda, G., Bozarth, I. F., & Cancedda, L.
- Affiliations
- Italian Institute of Technology (IT)
- Corresponding author
- Cancedda, Laura
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-05-22
- Volume
- 8
- Pages
- 119-119
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4033255
- OpenAlex
- W2104834189
- Cited by
- 192
- References
- 359
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 16 · 2023: 19 · 2022: 23 · 2021: 18 · 2020: 21 · 2019: 9 · 2018: 12 · 2017: 11 · 2016: 15 · 2015: 18 · 2014: 7
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by)
- Funders
- Compagnia di San Paolo
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Keywords
- GABAergic neurotransmission, GABAA receptor, GABAB receptors, neurodevelopmental disorders, neuronal development, synaptic modulation, intracellular chloride, GABA metabolism, autism spectrum disorder, fragile X syndrome, Rett syndrome, Down syndrome, schizophrenia, Tourette syndrome, neurofibromatosis, epilepsy, therapeutic target
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