Clostridioides difficile and neurological disorders: new perspectives
Open accessAbstract
Despite brain physiological functions or pathological dysfunctions relying on the activity of neuronal/non-neuronal populations, over the last decades a plethora of evidence unraveled the essential contribution of the microbial populations living and residing within the gut, called gut microbiota. The gut microbiota plays a role in brain (dys)functions, and it will become a promising valuable therapeutic target for several brain pathologies. In the present mini-review, after a brief overview of the role of gut microbiota in normal brain physiology and pathology, we focus on the role of the bacterium Clostridioides difficile, a pathogen responsible for recurrent and refractory infections, in people with neurological diseases, summarizing recent correlative and causative evidence in the scientific literature and highlighting the potential of microbiota-based strategies targeting this pathogen to ameliorate not only gastrointestinal but also the neurological symptoms.
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Evidence is emerging regarding the potential involvement of C. difficile in brain pathologies such as neurodegenerative diseases, multiple sclerosis, and autism spectrum disorder.
“Evidence is emerging regarding the potential involvement of C. difficile in brain pathologies such as neurodegenerative diseases (e.g. Parkinson’s disease, Alzheimer’s disease), multiple sclerosis, and autism spectrum disorder (455).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [455]
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- Authors
- Biazzo, M., Allegra, M., & Deidda, G.
- Affiliations
- University of Siena (IT)
- National Research Council (IT)
- University of Padua (IT)
- Corresponding author
- Deidda, Gabriele
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2022-09-20
- Volume
- 16
- Pages
- 946601-946601
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC9530032
- OpenAlex
- W4297906650
- Cited by
- 11
- References
- 112
- Citations by year
- 2026: 4 · 2025: 5 · 2023: 1 · 2022: 1
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Clostridium difficile, gut microbiota, neurological disorders, gut-brain axis, microbiota-based therapy, recurrent infections, neurodegenerative diseases, gut dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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