Cited by 32Neuroscience and Neuropharmacology ResearchEpilepsy research and treatmentIon Transport and Channel Regulation

Disruption of Slc4a10 augments neuronal excitability and modulates synaptic short-term plasticity

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Sinning, Anne, Liebmann, Lutz, Hübner, Christian A.·2015·Frontiers in Cellular Neuroscience

Abstract

Slc4a10 is a Na(+)-coupled Cl(-)-HCO3 (-) exchanger, which is expressed in principal and inhibitory neurons as well as in choroid plexus epithelial cells of the brain. Slc4a10 knockout (KO) mice have collapsed brain ventricles and display an increased seizure threshold, while heterozygous deletions in man have been associated with idiopathic epilepsy and other neurological symptoms. To further characterize the role of Slc4a10 for network excitability, we compared input-output relations as well as short and long term changes of evoked field potentials in Slc4a10 KO and wildtype (WT) mice. While responses of CA1 pyramidal neurons to stimulation of Schaffer collaterals were increased in Slc4a10 KO mice, evoked field potentials did not differ between genotypes in the stratum radiatum or the neocortical areas analyzed. Paired pulse facilitation was diminished in the hippocampus upon disruption of Slc4a10. In the neocortex paired pulse depression was increased. Though short term plasticity is modulated via Slc4a10, long term potentiation appears independent of Slc4a10. Our data support that Slc4a10 dampens neuronal excitability and thus sheds light on the pathophysiology of SLC4A10 associated pathologies.

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Crossref · 10.3389/fncel.2015.00223

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Authors
Sinning, A., Liebmann, L., & Hübner, C. A.
Affiliations
  • University Medical Center of the Johannes Gutenberg University Mainz (DE)
  • Jena University Hospital (DE)
Venue
Frontiers in Cellular Neuroscience
Published
2015-06-16
Volume
9
Pages
223-223
ISSN
1662-5102 (ISSN-L)
OpenAlex
W1547480653
Cited by
32
References
50
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 1 · 2015: 1
FWCI
1.08
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Deutsche Forschungsgemeinschaft (01GQ0923, HU 800/8-1)
  • Bundesministerium für Bildung und Forschung (01GQ0923)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
SLC4A10, neuronal excitability, paired-pulse facilitation, paired-pulse depression, long-term potentiation, CA1 pyramidal neurons, Schaffer collaterals, evoked field potentials, idiopathic epilepsy, hippocampus, neocortex, choroid plexus epithelial cells

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