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Elusive roles for reactive astrocytes in neurodegenerative diseases
Open accessAbstract
Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory response. They become reactive in response to virtually all pathological situations in the brain such as axotomy, ischemia, infection, and neurodegenerative diseases (ND). Astrocyte reactivity was originally characterized by morphological changes (hypertrophy, remodeling of processes) and the overexpression of the intermediate filament glial fibrillary acidic protein (GFAP). However, it is unclear how the normal supportive functions of astrocytes are altered by their reactive state. In ND, in which neuronal dysfunction and astrocyte reactivity take place over several years or decades, the issue is even more complex and highly debated, with several conflicting reports published recently. In this review, we discuss studies addressing the contribution of reactive astrocytes to ND. We describe the molecular triggers leading to astrocyte reactivity during ND, examine how some key astrocyte functions may be enhanced or altered during the disease process, and discuss how astrocyte reactivity may globally affect ND progression. Finally we will consider the anticipated developments in this important field. With this review, we aim to show that the detailed study of reactive astrocytes may open new perspectives for ND.
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“MAO subtypes are expressed by both neurons (MAOA, especially in basal ganglia) and reactive astrocytes (mainly MAOB) (Fowler et al., 2005; Ben Haim et al., 2015).”
From Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum (2020) · cites this paper as Ben Haim et al., 2015
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“Astrocytes are another major immune-competent cell population in the brain, and have long been proposed to play a role in neurodegeneration (Ben Haim et al., 2015; Liddelow et al., 2017).”
From Overexpressing low‐density lipoprotein receptor reduces tau‐associated neurodegeneration in relation to apoE‐linked mechanisms (2021) · cites this paper as Ben Haim et al., 2015
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Calcium's Role in Mechanotransduction during Muscle Development
Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,552
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210
Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation
Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126
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- Weigert, 1895, Beiträge zur Kenntnis der normalen menschlichen Neuroglia
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Items 401–454 of 454
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Castanho, I., Murray, T. K., Hannon, E. J., Jeffries, A. R., Walker, E., Laing, E., Baulf, H., Harvey, J., Randall, A. D., Moore, K., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/548578
Castanho, I., Murray, T. K., Hannon, E. J., Jeffries, A. R., Walker, E., Laing, E., Baulf, H., Harvey, J., Randall, A. D., Moore, K., et al. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3377366
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Hlavac, N. (2018) · VTechWorks (Virginia Tech)
Walia, K. (2020) · TSpace (University of Toronto)
Sterling, K. (2020) · York University Digital Library (York University)
Astrocyte and microglial aging
Peterson, T. A., & MacLean, A. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817990-1.00024-x
Atallah, M. N., & El-Gaber, A. A. (2022) · Journal of Bioscience and Applied Research/Journal of Bioscience and Applied Research · doi:10.21608/jbaar.2022.222520
Drosophila melanogaster: An Immaculate Model for Glial Research
Pragati, Tandon, S., Aqsa, A., Aggarwal, P., & Sarkar, S. (2022) · Springer eBooks · doi:10.1007/978-981-16-8313-8_26
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Badia‐Soteras, A. (2023) · doi:10.5463/thesis.127
The COVID-19–related neuroinflammation model may reveal relevant information on healthy longevity
Luiz, M. V. D. S. J., Silva, J. D. N., Andreotti, D. Z., Mello, P. S. D., Nagy, G. S., Filho, O. P. D. A., & Kawamoto, E. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85841-0.00008-0
Milton, M. (2023) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2023-15641
Mousavi, M., Meknatkhah, S., Imani, A., Geramifar, P., & Riazi, G. H. (2023) · Scientific Reports · doi:10.1038/s41598-023-43721-7 · Cited by 2
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You, H., & Pei, Z. (2023) · Contemporary clinical neuroscience · doi:10.1007/978-3-031-32815-2_12
Hanotte, J. L. (2023) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/161150
Revolutionizing Dementia Management: Insights and Progress from the Asian Pacific Region
Verma, N. K. (2024) · Acta Scientific Medical Sciences · doi:10.31080/asms.2024.08.1751
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Singh, D. K., Rahman, A., Gupta, R., Verma, A. K., Mir, Q. A., & Mir, R. A. (2025) · Springer eBooks · doi:10.1007/978-981-96-6202-9_7
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Cho, I., Kim, J. M., Kim, E. J., Kim, S. Y., Kam, E. H., Cheong, E., Suh, M., & Koo, B.-N. (2021) · Figshare · doi:10.6084/m9.figshare.14429042
Pérez-Núñez, R., Chamorro, A., González, M. F., Contreras, P., Artigas, R., Corvalán, A. H., van Zundert, B., Reyes, C., Moya, P. R., Avalos, A. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26559617
Karnam, S., Maurya, S., Ng, E., Choudhary, A., Thobani, A., Flanagan, J. G., & Gronert, K. (2024) · Figshare · doi:10.6084/m9.figshare.26705538
Karnam, S., Maurya, S., Ng, E., Choudhary, A., Thobani, A., Flanagan, J. G., & Gronert, K. (2024) · Figshare · doi:10.6084/m9.figshare.26705535
Makarava, N., Mychko, O., Chang, J. C., Molesworth, K., & Baskakov, I. V. (2021) · Figshare · doi:10.6084/m9.figshare.14583799
Lun, J., Li, Y., Gao, X., Gong, Z., Chen, X., Zou, J., Zhou, C., Huang, Y., Zhou, B., Huang, P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26579183
Stym‐Popper, G., Matta, K., Chaigneau, T., Rupra, R., Demetriou, A., Fouquet, S., Dansokho, C., Toly‐Ndour, C., & Dorothée, G. (2023) · Figshare · doi:10.6084/m9.figshare.22620755
Lun, J., Li, Y., Gao, X., Gong, Z., Chen, X., Zou, J., Zhou, C., Huang, Y., Zhou, B., Huang, P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26579180
Pérez-Núñez, R., Chamorro, A., González, M. F., Contreras, P., Artigas, R., Corvalán, A. H., van Zundert, B., Reyes, C., Moya, P. R., Avalos, A. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26559620
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Makarava, N., Mychko, O., Chang, J. C., Molesworth, K., & Baskakov, I. V. (2021) · Figshare · doi:10.6084/m9.figshare.14583817
Cho, I., Kim, J. M., Kim, E. J., Kim, S. Y., Kam, E. H., Cheong, E., Suh, M., & Koo, B.-N. (2021) · Figshare · doi:10.6084/m9.figshare.14429048
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Serrenho, I., Mendes, V. M., Caramelo, I., Cardoso, C. M. P., Manadas, B. J., & Baltazar, G. (2026) · Stem Cell Reviews and Reports · doi:10.1007/s12015-026-11089-6
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Vautheny, A. (2019) · theses.fr (ABES) · doi:10.70675/1812d71aze8d9z48d6z87d1z5a23a4e81953
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Megemont, M. (2019) · theses.fr (ABES) · doi:10.70675/c0dcb017z7bb2z46e9zb39azc730e2593a65
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Clément, T. (2020) · theses.fr (ABES) · doi:10.70675/2892171fzc838z4d9azbf65zf208dafdf173
Hemonnot-Girard, A.-L. (2021) · theses.fr (ABES) · doi:10.70675/9c8a4775zd774z494ez9bbazf7566faefa8f
Poulot-Becq-Giraudon, Y. (2024) · theses.fr (ABES) · doi:10.70675/0d7a8b92z8393z4d76z82a8z87efe0790346
Mielnicka, W., Sławińska, J., Mikołajczyk, J., Hawajski, A., Nowak, J., Mieruszyńska, S., Szeidl, O., Kołodziejska, M., Lewandowski, M., & Cupiał, A. (2026) · Aktualności Neurologiczne · doi:10.15557/an.2025.0026
Purushotham, S. S., Chesworth, R., Keembiyage, N., Münch, G. W., Gyengési, E., & Buskila, Y. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106183
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Pervaiz, I., Blazier, A. S., Nyarko‐Danquah, I., Wesseling, H., Ramos, A., Woodworth, L. A., Taksir, T. V., Ryan, S. K., Wirak, G. S., Zhao, Z., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-10323-8
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Majumdar, S., Prajapati, S. K., Samaiya, P. K., Bhattacharya, S., & Krishnamurthy, S. (2026) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898815646126010007
Luque-Bolivar, A., Ruiz-Araujo, K., Aristizábal-Pachón, A. F., & González, J. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1870142
Lötzsch, C., Schmidt, J. J., Delev, D., Coras, R., Blümcke, I., & Beckervordersandforth, R. (2026) · Epilepsia Open · doi:10.1002/epi4.70324
Nejtek, V. A., James, R., Boehm, G. W., Alphonso, H. M., Brice, K. N., Soto, I., Braden-Kuhle, P. N., Doshier, K., & Salvatore, M. F. (2026) · medRxiv · doi:10.64898/2026.08.10.26360106
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Metadata
- Authors
- Ben Haim, L., Carrillo-de Sauvage, M.-A., Ceyzériat, K., & Escartin, C.
- Affiliations
- Université Paris-Sud (FR)
- Corresponding author
- Escartin, Carole
- ORCID
- Escartin, Carole
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-08-03
- Volume
- 9
- Pages
- 278-278
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4522610
- OpenAlex
- W1569924411
- Cited by
- 453
- References
- 309
- Citations by year
- 2026: 19 · 2025: 35 · 2024: 39 · 2023: 35 · 2022: 41 · 2021: 57 · 2020: 46 · 2019: 46 · 2018: 55 · 2017: 43 · 2016: 34 · 2015: 3
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agence Nationale de la Recherche (ANR-10-JCJC-1402, 2011-BSV4-021-03)
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- reactive astrocytes, astrocyte activation, neurodegenerative diseases, neuroinflammation, glial fibrillary acidic protein, astrocyte function, disease progression
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