Cited by 454Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchAlzheimer's disease research and treatments

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Elusive roles for reactive astrocytes in neurodegenerative diseases

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Ben Haim, Lucile, Carrillo-de Sauvage, Maria-Angeles, CeyzÃ©riat, Kelly, Escartin, Carole·2015·Frontiers in Cellular Neuroscience

DOI 10.3389/fncel.2015.00278PMC PMC4522610

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Abstract

Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory response. They become reactive in response to virtually all pathological situations in the brain such as axotomy, ischemia, infection, and neurodegenerative diseases (ND). Astrocyte reactivity was originally characterized by morphological changes (hypertrophy, remodeling of processes) and the overexpression of the intermediate filament glial fibrillary acidic protein (GFAP). However, it is unclear how the normal supportive functions of astrocytes are altered by their reactive state. In ND, in which neuronal dysfunction and astrocyte reactivity take place over several years or decades, the issue is even more complex and highly debated, with several conflicting reports published recently. In this review, we discuss studies addressing the contribution of reactive astrocytes to ND. We describe the molecular triggers leading to astrocyte reactivity during ND, examine how some key astrocyte functions may be enhanced or altered during the disease process, and discuss how astrocyte reactivity may globally affect ND progression. Finally we will consider the anticipated developments in this important field. With this review, we aim to show that the detailed study of reactive astrocytes may open new perspectives for ND.

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Affiliations: Université Paris-Sud (FR)
Corresponding author: Escartin, Carole
ORCID: Escartin, Carole
Venue: Frontiers in Cellular Neuroscience
Publisher: Frontiers Media SA
Published: 2015-08-03
Volume: 9
Pages: 278-278
ISSN: 1662-5102 (ISSN-L)
DOI: 10.3389/fncel.2015.00278
PMC: PMC4522610
OpenAlex: W1569924411
Cited by: 453
References: 309
Citations by year: 2026: 19 · 2025: 35 · 2024: 39 · 2023: 35 · 2022: 41 · 2021: 57 · 2020: 46 · 2019: 46 · 2018: 55 · 2017: 43 · 2016: 34 · 2015: 3
FWCI: 3.59
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Agence Nationale de la Recherche (ANR-10-JCJC-1402, 2011-BSV4-021-03)
Centre National de la Recherche Scientifique
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: reactive astrocytes, astrocyte activation, neurodegenerative diseases, neuroinflammation, glial fibrillary acidic protein, astrocyte function, disease progression

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Elusive roles for reactive astrocytes in neurodegenerative diseases

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