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Brain-Derived Neurotrophic Factor (BDNF) Regulates Rab5-Positive Early Endosomes in Hippocampal Neurons to Induce Dendritic Branching
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Rab5 activity is required for maintenance of basal dendritic complexity and for the increase in dendritic complexity induced by BDNF in hippocampal neurons.
“We have previously shown that Rab5 activity is required for both the maintenance of basal dendritic complexity and for the increase in dendritic complexity induced by BDNF in hippocampal neurons.”
From The Rab5–Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons (2020) · cites this paper as Moya-Alvarado et al., 2018
Rab11DN-expressing neurons did not show a decrease in basal dendritic complexity at 7 DIV and are specifically required for BDNF-induced dendritic branching.
“Rab11DN-expressing neurons, however, did not show a decrease in basal dendritic complexity at 7 DIV and are thus specifically required for BDNF-induced dendritic branching (Lazo et al., 2013;Moya-Alvarado et al., 2018).”
From The Rab5–Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons (2020) · cites this paper as Moya-Alvarado et al., 2018
Endocytic pathways regulate the propagation of BDNF signaling to the nucleus in addition to the local events reported previously.
“Altogether, our results suggest that endocytic pathways regulate the propagation of BDNF signaling to the nucleus in addition to the local events reported previously (Huang et al., 2013;Lazo et al., 2013;Moya-Alvarado et al., 2018).”
From The Rab5–Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons (2020) · cites this paper as Moya-Alvarado et al., 2018
BDNF/TrkB signaling regulates Rab5 and Rab11 activity and dynamics.
“In addition, BDNF/TrkB signaling regulates Rab5 and Rab11 activity and dynamics, suggesting that both GTPases are downstream targets of BDNF/TrkB signaling (Lazo et al., 2013;Moya-Alvarado et al., 2018).”
From The Rab5–Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons (2020) · cites this paper as Moya-Alvarado et al., 2018
Rab5 and Rab11 are critical for BDNF-mediated dendritic branching.
“both GTPases are critical for BDNF-mediated dendritic branching (Lazo et al., 2013;Moya-Alvarado et al., 2018).”
From The Rab5–Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons (2020) · cites this paper as Moya-Alvarado et al., 2018
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Citations
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“These phosphotyrosines are docking sites for adaptor proteins that lead to the activation of several signaling cascades including the mitogen-activated protein kinases (MAPKs), such as ERK1/2, ERK5 and p38, in addition to the phosphatidylinositol-3-kinase (PI3K)-Akt-mTOR pathway, phospholipase C-γ (PLC-γ) and the smal…”
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Sorted by citations
González-Gutiérrez, A., Lazo, O. M., & Bronfman, F. C. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.2063-19.2020 · Cited by 38
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Metadata
- Authors
- Moya-Alvarado, G., Gonzalez, A., Stuardo, N., & Bronfman, F. C.
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2018-12-17
- Volume
- 12
- ISSN
- 1662-5102
- PMC
- PMC6304382
- Cited by
- 57
- References
- 4
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