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BDNF Regulates Rab11-Mediated Recycling Endosome Dynamics to Induce Dendritic Branching

Lazo, Oscar M., Gonzalez, Andrés, Ascaño, Maria, Kuruvilla, Rejji, Couve, Andrés, Bronfman, Francisca C.·2013·The Journal of Neuroscience
DOI 10.1523/jneurosci.4630-12.2013PMC PMC3684039
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Abstract

Dendritic arborization of neurons is regulated by brain-derived neurotrophic factor (BDNF) together with its receptor, TrkB. Endocytosis is required for dendritic branching and regulates TrkB signaling, but how postendocytic trafficking determines the neuronal response to BDNF is not well understood. The monomeric GTPase Rab11 regulates the dynamics of recycling endosomes and local delivery of receptors to specific dendritic compartments. We investigated whether Rab11-dependent trafficking of TrkB in dendrites regulates BDNF-induced dendritic branching in rat hippocampal neurons. We report that TrkB in dendrites is a cargo for Rab11 endosomes and that both Rab11 and its effector, MyoVb, are required for BDNF/TrkB-induced dendritic branching. In addition, BDNF induces the accumulation of Rab11-positive endosomes and GTP-bound Rab11 in dendrites and the expression of a constitutively active mutant of Rab11 is sufficient to increase dendritic branching by increasing TrkB localization in dendrites and enhancing sensitization to endogenous BDNF. We propose that Rab11-dependent dendritic recycling provides a mechanism to retain TrkB in dendrites and to increase local signaling to regulate arborization.

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Crossref · 10.1523/jneurosci.4630-12.2013

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  • Rab11DN-expressing neurons did not show a decrease in basal dendritic complexity at 7 DIV and are specifically required for BDNF-induced dendritic branching.

    “Rab11DN-expressing neurons, however, did not show a decrease in basal dendritic complexity at 7 DIV and are thus specifically required for BDNF-induced dendritic branching (Lazo et al., 2013;Moya-Alvarado et al., 2018).”

    From The Rab5–Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons (2020) · cites this paper as Lazo et al., 2013

    The Results section ('BDNF-induced dendritic branching requires Rab11'; page unavailable) reports that Rab11DN abolished BDNF-dependent dendritic growth in hippocampal neurons treated at 7 DIV. It does not state that Rab11DN-expressing neurons had unchanged basal dendritic complexity. The Methods section says arborization was assessed 48 hours after treatment, rather than at 7 DIV. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Rab5 activity is required for maintenance of basal dendritic complexity and for the increase in dendritic complexity induced by BDNF in hippocampal neurons.

    “We have previously shown that Rab5 activity is required for both the maintenance of basal dendritic complexity and for the increase in dendritic complexity induced by BDNF in hippocampal neurons.”

    From The Rab5–Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons (2020) · cites this paper as Lazo et al., 2013

    The Results section, “BDNF-induced dendritic branching requires Rab11” (page unavailable), reports that inhibiting Rab11 abolished BDNF-dependent dendritic growth in hippocampal neurons. A search for Rab5 and basal dendritic complexity found no passage establishing the attributed requirement for Rab5; the Rab11 finding does not rule it out. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • BDNF/TrkB signaling regulates Rab5 and Rab11 activity and dynamics.

    “In addition, BDNF/TrkB signaling regulates Rab5 and Rab11 activity and dynamics, suggesting that both GTPases are downstream targets of BDNF/TrkB signaling (Lazo et al., 2013;Moya-Alvarado et al., 2018).”

    From The Rab5–Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons (2020) · cites this paper as Lazo et al., 2013

  • Rab5 and Rab11 are critical for BDNF-mediated dendritic branching.

    “both GTPases are critical for BDNF-mediated dendritic branching (Lazo et al., 2013;Moya-Alvarado et al., 2018).”

    From The Rab5–Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons (2020) · cites this paper as Lazo et al., 2013

  • Endocytic pathways regulate the propagation of BDNF signaling to the nucleus in addition to the local events reported previously.

    “Altogether, our results suggest that endocytic pathways regulate the propagation of BDNF signaling to the nucleus in addition to the local events reported previously (Huang et al., 2013;Lazo et al., 2013;Moya-Alvarado et al., 2018).”

    From The Rab5–Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons (2020) · cites this paper as Lazo et al., 2013

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Citations

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Metadata

Authors
Lazo, O. M., Gonzalez, A., Ascaño, M., Kuruvilla, R., Couve, A., & Bronfman, F. C.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2013-04-03
Volume
33
Issue
14
Pages
6112-6122
ISSN
  • 0270-6474
  • 1529-2401
DOI
10.1523/jneurosci.4630-12.2013
PMC
PMC3684039
Cited by
137
References
2
Language
en
Licence
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)

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