Identification of a Novel Family of Oligodendrocyte Lineage-Specific Basic Helix–Loop–Helix Transcription Factors
Open accessAbstract
Basic helix-loop-helix (bHLH) transcription factors have been identified for neurons and their precursors but not for glial cells. We have identified two bHLH factors, Oligo1 and Oligo2, that are specifically expressed in zones of neuroepithelium from which oligodendrocyte precursors emerge, as well as in the precursors themselves. Expression of Oligo2 in the spinal cord precedes that of platelet-derived growth factor receptor alpha (PDGFRalpha), the earliest known marker of oligodendrocyte precursors, by several days. Ectopic expression of Oligo2 in vivo causes ectopic expression of Sox10, an HMG-box transcription factor expressed in oligodendrocyte and other glial precursors. These data identify Oligo genes as the earliest known markers of oligodendrocyte lineage determination and suggest they play a causal role in this process.
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OLIG2 is a chromosome 21-encoded gene that is a master regulator for oligodendrocyte development.
“Much of the work in DS has focused on OLIG2, a chromosome 21-encoded gene that is a master regulator for oligodendrocyte development92,93,108.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [108]
The Results identify human Oligo2 on chromosome 21q. The Abstract and Discussion report that Oligo2 is expressed early in the oligodendrocyte lineage and that ectopic expression induces Sox10, but describe a causal role as suggested, not established. Calling it a “master regulator” overstates what this paper demonstrates. (LLM, conf=0.88)
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“Much of the work in DS has focused on OLIG2 , a chromosome 21-encoded gene that is a master regulator for oligodendrocyte development 92,93,108 .”
- Authors
- Zhou, Q., Wang, S., & Anderson, D. J.
- Affiliations
- California Institute of Technology (US)
- Stanford Medicine (US)
- Corresponding author
- Anderson, David J
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 25
- Issue
- 2
- Pages
- 331-343
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2129605816
- Cited by
- 789
- References
- 1
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 22 · 2023: 18 · 2022: 26 · 2021: 27 · 2020: 23 · 2019: 23 · 2018: 15 · 2017: 20 · 2016: 22 · 2015: 28 · 2014: 36 · 2013: 35 · 2012: 33
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Institutes of Health (RO1 NS23476)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Keywords
- bHLH transcription factors, oligodendrocyte lineage, oligodendrocyte precursor cells, lineage determination, SOX10, PDGFRA, spinal cord development, neuroepithelium, glial differentiation, ectopic expression
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Animals, Chick Embryo, DNA-Binding Proteins, Multigene Family, Genetic Testing, High Mobility Group Proteins, Mesencephalon, Molecular Sequence Data, Nerve Tissue Proteins, Oligodendroglia, Rhombencephalon, Spinal Cord, Stem Cells, Transcription Factors, Gene Library, Sequence Homology, Amino Acid, Helix-Loop-Helix Motifs, Gene Expression Regulation, Developmental, Cell Lineage, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, SOXE Transcription Factors
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