The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves
Open accessAbstract
The peripheral nervous system has remarkable regenerative capacities in that it can repair a fully cut nerve. This requires Schwann cells to migrate collectively to guide regrowing axons across a 'bridge' of new tissue, which forms to reconnect a severed nerve. Here we show that blood vessels direct the migrating cords of Schwann cells. This multicellular process is initiated by hypoxia, selectively sensed by macrophages within the bridge, which via VEGF-A secretion induce a polarized vasculature that relieves the hypoxia. Schwann cells then use the blood vessels as "tracks" to cross the bridge taking regrowing axons with them. Importantly, disrupting the organization of the newly formed blood vessels in vivo, either by inhibiting the angiogenic signal or by re-orienting them, compromises Schwann cell directionality resulting in defective nerve repair. This study provides important insights into how the choreography of multiple cell-types is required for the regeneration of an adult tissue.
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Cites
Macrophage Diversity Enhances Tumor Progression and Metastasis
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Macrophage biology in development, homeostasis and disease
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“Other studies have also reported a role for macrophages in inducing blood vessels following injury, suggesting that this may be a general mechanism (Wynn et al., 2013).”
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Cited by
Macrophages in Tissue Repair, Regeneration, and Fibrosis
Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481
Macrophages in health and disease
Park, M. D., Silvin, A., Ginhoux, F., & Merad, M. (2022) · Cell · doi:10.1016/j.cell.2022.10.007 · Cited by 644
The Success and Failure of the Schwann Cell Response to Nerve Injury
Jessen, K. R., & Mirsky, R. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00033 · Cited by 466
Vascular endothelial growth factor: a neurovascular target in neurological diseases
Lange, C., Storkebaum, E., de Almodóvar, C. R., Dewerchin, M., & Carmeliet, P. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.88 · Cited by 382
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371
Metadata
- Authors
- Cattin, A.-L., Burden, J. J., Van Emmenis, L., Mackenzie, F. E., Hoving, J. J. A., Garcia Calavia, N., Guo, Y., McLaughlin, M., Rosenberg, L. H., Quereda, V., Jamecna, D., Napoli, I., Parrinello, S., Enver, T., Ruhrberg, C., & Lloyd, A. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 162
- Issue
- 5
- Pages
- 1127-1139
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1935201742
- Cited by
- 936
- References
- 43
- FWCI
- 17.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cattin, A.-L., Burden, J. J., Van Emmenis, L., Mackenzie, F. E., Hoving, J. J. A., Garcia Calavia, N., Guo, Y., McLaughlin, M., Rosenberg, L. H., Quereda, V., Jamecna, D., Napoli, I., Parrinello, S., Enver, T., Ruhrberg, C., & Lloyd, A. C. (2015). Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves. Cell. https://doi.org/10.1016/j.cell.2015.07.021
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
