Intrusive Thoughts Elicited by Direct Electrical Stimulation during Stereo-Electroencephalography
Open accessAbstract
Cortical direct electrical stimulation (DES) is a method of brain mapping used during invasive presurgical evaluation of patients with intractable epilepsy. Intellectual auras like intrusive thoughts, also known as forced thinking (FT), have been reported during frontal seizures. However, there are few reports on FT obtained during DES in frontal cortex. We report three cases in which we obtained intrusive thoughts while stimulating the dorsolateral prefrontal cortex and the white matter in the prefrontal region. In order to highlight the effective connectivity that might explain this clinical response, we have analyzed cortico-cortical potentials evoked by single pulse electrical stimulation.
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Popa et al. (2016) provide further confirmation of the rarity of changes in conscious content following iES to posterior subregions of the lateral PFC and the extent to which these rare elicited experiences are devoid of perceptual content.
“While effects following stimulation of white-matter pathways should be interpreted with caution, Popa et al. (2016) nonetheless provide further confirmation of the rarity of changes in conscious content following iES to posterior subregions of the lateral PFC and the extent to which these rare elicited experiences are devoid of perceptual content.”
From Does the Prefrontal Cortex Play an Essential Role in Consciousness? Insights from Intracranial Electrical Stimulation of the Human Brain (2021) · cites this paper as Popa et al., 2016
The Results (page unavailable) describe intrusive thoughts elicited by stimulation of the DLPFC in P1; the Discussion says the responses differed from auditory hallucinations and inner speech. This supports the characterization of the reported experiences as nonperceptual. The paper does not establish how rarely stimulation of posterior lateral PFC changes conscious content: it reports three cases, two involving stimulation of underlying white matter, without a rate for that subregion. (LLM, conf=0.84)
Experimental — accuracy not yet measuredPopa et al. (2016) reported 1 patient in whom DLPFC stimulation produced conceptual thought, and 2 patients in whom iES of white matter underlying the posterolateral PFC caused reportable changes in thought content.
“In another study, Popa et al. (2016) reported 1 patient in whom stimulation to the DLPFC produced similar reports of conceptual thought following stimulation, as well as 2 patients in whom iES of white matter underlying the posterolateral PFC caused reportable changes in thought content.”
From Does the Prefrontal Cortex Play an Essential Role in Consciousness? Insights from Intracranial Electrical Stimulation of the Human Brain (2021) · cites this paper as Popa et al., 2016
The Discussion reports intrusive thoughts during DLPFC stimulation in P1 and white-matter stimulation beneath the PFC in P2 and P3; the Results describe the patients’ reported changes in thought content. The paper does not identify the white matter stimulated in both P2 and P3 as underlying the posterolateral PFC, so that anatomical qualifier is not established by our copy (no page numbers provided). (LLM, conf=0.85)
Experimental — accuracy not yet measuredThere are isolated case reports of thoughts and visual hallucinations elicited by iES of the more ventral and posterior portions of the lateral PFC.
“There are exceptions to this general trend, however, with some isolated case reports of thoughts (Popa et al., 2016;A. Liu et al., 2020) and visual hallucinations (Blanke et al., 2000;Vignal et al., 2000) elicited by iES of the more ventral and posterior portions of the lateral PFC (Fig. 4).”
From Does the Prefrontal Cortex Play an Essential Role in Consciousness? Insights from Intracranial Electrical Stimulation of the Human Brain (2021) · cites this paper as Popa et al., 2016
The Results report intrusive thoughts elicited by stimulation in three patients, including at a dorsolateral prefrontal site (P1) and a middle frontal gyrus site (P3). The Results and Discussion also locate stimulation in prefrontal white matter; they do not establish that the sites were specifically the more ventral and posterior portions of lateral PFC. The visual-hallucination part of the citing sentence is attributed to other papers, not Popa et al. (LLM, conf=0.82)
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- Authors
- Popa, I., Donos, C., Barborica, A., Opris, I., Mălîia, M. D., Ene, M., Ciurea, J., & Mîndruţă, I.
- Affiliations
- Bucharest Emergency University Hospital (RO)
- University of Bucharest (RO)
- University of Miami (US)
- Venue
- Frontiers in Neurology
- Publisher
- Frontiers Media SA
- Published
- 2016-07-18
- Volume
- 7
- Pages
- 114-114
- ISSN
- 1664-2295 (ISSN-L)
- PMC
- PMC4947963
- OpenAlex
- W2499117221
- Cited by
- 26
- References
- 24
- Citations by year
- 2026: 2 · 2024: 8 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2017: 4 · 2016: 1
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neurology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii (PN-II-ID-PCE-2011-3-0240, PN-II-PT-PCCA-2011-3.2-1290)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Keywords
- intrusive thoughts, direct electrical stimulation, stereoelectroencephalography, drug-resistant epilepsy, frontal lobe epilepsy, dorsolateral prefrontal cortex, prefrontal white matter, effective connectivity, preoperative assessment
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