The DOI matches its Crossref record; 233 of the 236 references it cites were found in a registry or an index.
Hypocretin as a Hub for Arousal and Motivation
Open accessAbstract
The lateral hypothalamus is comprised of a heterogeneous mix of neurons that serve to integrate and regulate sleep, feeding, stress, energy balance, reward, and motivated behavior. Within these populations, the hypocretin/orexin neurons are among the most well studied. Here, we provide an overview on how these neurons act as a central hub integrating sensory and physiological information to tune arousal and motivated behavior accordingly. We give special attention to their role in sleep-wake states and conditions of hyper-arousal, as is the case with stress-induced anxiety. We further discuss their roles in feeding, drug-seeking, and sexual behavior, which are all dependent on the motivational state of the animal. We further emphasize the application of powerful techniques, such as optogenetics, chemogenetics, and fiber photometry, to delineate the role these neurons play in lateral hypothalamic functions.
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“orexin maintains wakefulness and arousal, as well as regulates sleep stability.17–21”
From Effects of Traumatic Brain Injury on the Orexin/Hypocretin System (2025) · cites this paper as [20]
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Metadata
- Authors
- Tyree, S. M., Borniger, J. C., & de Lecea, L.
- Affiliations
- Stanford University (US)
- Venue
- Frontiers in Neurology
- Publisher
- Frontiers Media SA
- Published
- 2018-06-06
- Volume
- 9
- Pages
- 413-413
- ISSN
- 1664-2295 (ISSN-L)
- PMC
- PMC5997825
- OpenAlex
- W2806993167
- Cited by
- 83
- References
- 236
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 5 · 2023: 9 · 2022: 15 · 2021: 12 · 2020: 19 · 2019: 10 · 2018: 3
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Neurology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Neurological Foundation of New Zealand
- Foundation for the National Institutes of Health (F32MH11543, 5R01MH087592, R01MH1026380, 1R01AG047671)
- Boehringer Ingelheim
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- hypocretin/orexin neurons, lateral hypothalamus, arousal, motivation, sleep-wake regulation, hyperarousal, stress-induced anxiety, feeding behavior, drug-seeking behavior, sexual behavior, optogenetics, chemogenetics, fiber photometry
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